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Application of Microwave-Assisted Method for Lutein Extraction from Pistachio WasteJournal of nuts
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2024 26 49
Guidance on selecting optimal steady-state tacrolimus concentrations for continuous IV perfusion : insights from physiologically based pharmacokinetic modelingPharmaceuticals
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2024 6 2
Optimization of Lutein Extraction from Pistachio Waste Using Experimental Design and Ultrasonic MethodWaste and biomass valorization
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2024 43 0
Stereoselective separation of omeprazole and 5-hydroxy-omeprazole using dried plasma spots and a heart-cutting 2D-LC approach for accurate CYP2C19 phenotypingJournal of chromatography. B
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2024 29 23
Practice of CYP450 genotyping and phenotyping in children in a real-life settingFrontiers in pharmacology
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2023 25 8
Phenotyping Indices of CYP450 and P-Glycoprotein in Human Volunteers and in Patients Treated with Painkillers or Psychotropic DrugsPharmaceutics
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2023 26 26
Apixaban and rivaroxaban's physiologically-based pharmacokinetic model validation in hospitalized patients: A first step for larger use of a priori modeling approach at bed sideCPT: pharmacometrics & systems pharmacology
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2023 77 47
Evaluation of important human CYP450 isoforms and P-glycoprotein phenotype changes and genotype in type 2 diabetic patients, before and after intensifying treatment regimen using Geneva cocktailBasic & clinical pharmacology & toxicology
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2023 40 0
Evaluation of Pupillometry for CYP2D6 Phenotyping in Children Treated with TramadolPharmaceuticals
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2023 26 11
Pharmacokinetic Modeling and Simulation with Pharmacogenetic Insights Support the Relevance of Therapeutic Drug Monitoring for Myeloablative Busulfan Dosing in Adult HSCTTransplantation and cellular therapy
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2023 31 32
Impact of obesity and bariatric surgery on metabolic enzymes and p-glycoprotein activity using the Geneva cocktail approachJournal of personalized medicine
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2023 31 6
Medical cannabinoids for painful symptoms in patients with severe dementia: a randomized, double-blind cross-over placebo-controlled trial protocolFrontiers in pain research
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2023 61 6
Population pharmacokinetics of apixaban in a real-life hospitalized population from the OptimAT studyCPT: pharmacometrics & systems pharmacology
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2023 38 20
Joint Analysis of Phenotypic and Genomic Diversity Sheds Light on the Evolution of Xenobiotic Metabolism in HumansGenome biology and evolution
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2022 294 42
Editorial: Precision Medicine: Impact of Cytochromes P450 and Transporters Genetic Polymorphisms, Drug-Drug Interactions, Disease on Safety and Efficacy of DrugsFrontiers in pharmacology
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2022 133 84
Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and ResponsePharmaceuticals
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2022 49 10
Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spotsClinical and translational science
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2022 164 60
Dexamethasone exposure in normal-weight and obese hospitalized COVID-19 patients: An observational exploratory trialClinical and translational science
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2022 90 29
Impact of the Genotype and Phenotype of CYP3A and P-gp on the Apixaban and Rivaroxaban Exposure in a Real-World SettingJournal of personalized medicine
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2022 151 112
Case Report: Opioid Use Disorder Associated With Low/Moderate Dose of Loperamide in an Intellectual Disability Patient With CYP3A and P-Glycoprotein Reduced ActivityFrontiers in psychiatry
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2022 22 29
Cannabinoids for behavioral symptoms in severe dementia: Safety and feasibility in a long-term pilot observational study in nineteen patientsFrontiers in aging neuroscience
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2022 49 9
Population Pharmacokinetic Models for Direct Oral Anticoagulants: A Systematic Review and Clinical Appraisal Using Exposure SimulationClinical pharmacology and therapeutics
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2022 100 99
Prediction of cytochromes P450 3A and 2C19 modulation by both inflammation and drug interactions using physiologically based pharmacokineticsCPT: pharmacometrics & systems pharmacology
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2022 179 231
Variations in the Frequencies of Polymorphisms in the CYP450s Genes in Eight Major Ethnicities of Iran: A Review of the Human DataJournal of personalized medicine
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2022 19 6
Liquid Biopsy for Patient Characterization in Cardiovascular Disease: Verification against Markers of Cytochrome P450 and P-Glycoprotein ActivitiesClinical pharmacology & therapeutics
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2022 112 184
Personalized Medicine : PharmacokineticsJournal of personalized medicine
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2022 22 3
Impact of SARS-CoV-2 Infection (COVID-19) on Cytochromes P450 Activity Assessed by the Geneva CocktailClinical pharmacology and therapeutics
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2021 139 57
Mesoporous Silica Nanoparticles as pH-Responsive Carrier for the Immune-Activating Drug Resiquimod Enhance the Local Immune Response in MiceACS Nano
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2021 291 418
Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug TherapyAnnual Review of Pharmacology and Toxicology
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2021 268 1
Drug-drug interactions with direct oral anticoagulants: practical recommendations for cliniciansThe American journal of medicine
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2021 101 0
Mixing Drugs and Genetics: A Complex Hemorrhagic CocktailAmerican Journal of Medicine
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2021 227 5
CYP450 Genotype-Phenotype Concordance Using the Geneva Micrococktail in a Clinical SettingFrontiers in pharmacology
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2021 195 73
The 1β-Hydroxy-Deoxycholic Acid to Deoxycholic Acid Urinary Metabolic Ratio: Toward a Phenotyping of CYP3A Using an Endogenous Marker?Journal of personalized medicine
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2021 162 32
Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activityBritish journal of pharmacology
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2021 249 100
The tyrosine kinase inhibitor nilotinib inhibits SARS‐CoV‐2 in vitroBasic & Clinical Pharmacology & Toxicology
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2021 173 2
Simultaneous determination of melatonin and 6-hydroxymelatonin in human overnight urine by LC-MS/MSJournal of chromatography. B
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2021 268 252
Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human DataJournal of personalized medicine
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2021 129 47
Reviewing Data Integrated for PBPK Model Development to Predict Metabolic Drug-Drug Interactions: Shifting Perspectives and Emerging TrendsFrontiers in pharmacology
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2021 109 134
Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic studyCPT: pharmacometrics & systems pharmacology
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2021 186 83
Optimized low‐dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatmentMolecular Oncology
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2020 361 154
Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysisBritish Journal of Clinical Pharmacology
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2020 167 101
Safety of the Geneva Cocktail, a Cytochrome P450 and P-Glycoprotein Phenotyping Cocktail, in Healthy Volunteers from Three Different Geographic OriginsDrug Safety
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2020 501 135
Impact of acute inflammation on cytochromes P450 activity assessed by the Geneva CocktailClinical Pharmacology and Therapeutics
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2020 256 289
GABAergic modulation of secondary hyperalgesia: A randomized controlled 4-way crossover trial with the α2-subunit preferring GABA positive allosteric modulator, N-desmethyl-clobazam in healthy volunteersEuropean Journal of Pain
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2020 204 1
Bioavailability of Vortioxetine After a Roux-en-Y Gastric BypassObesity Surgery
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2020 209 1
Deep proteomics and phosphoproteomics reveal novel biological pathways perturbed by morphine, morphine-3-glucuronide and morphine-6-glucuronide in human astrocytesJournal of Neuroscience Research
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2020 251 2
Modern approaches for the phenotyping of cytochrome P450 enzymes in childrenExpert Review of Clinical Pharmacology
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2020 155 1
Comparing Dried Blood Spots and Plasma Concentrations for Busulfan Therapeutic Drug Monitoring in ChildrenTherapeutic Drug Monitoring
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2020 349 130
Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patientsJournal of Thrombosis and Haemostasis
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2020 209 1
Evaluation of Phenotypic and Genotypic Variations of Drug Metabolising Enzymes and Transporters in Chronic Pain Patients Facing Adverse Drug Reactions or Non-Response to Analgesics: A Retrospective StudyJournal of Personalized Medicine
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2020 297 71
Interaction between Fexofenadine and CYP Phenotyping Probe Drugs in Geneva CocktailJournal of Personalized Medicine
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2019 321 151
Phenotyping of human CYP450 enzymes by endobiotics: current knowledge and methodological approachesClinical Pharmacokinetics
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2019 333 3
Variables of interest to predict glomerular filtration rate in preterm newborns in the first days of lifePediatric Nephrology
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2019 331 1
Towards personalized antithrombotic treatments: focus on P2Y12 inhibitors and direct oral anticoagulantsClinical Pharmacokinetics
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2019 405 2
Drug-induced expression of the RNA-binding protein HuR attenuates the adaptive response to BRAF inhibition in melanomaBiochemical and Biophysical Research Communications
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2019 310 224
Liquid Chromatography-Tandem Mass Spectrometry Method for Ticagrelor and its Active Metabolite Determination in Human Plasma: Application to a Pharmacokinetic StudyCurrent Analytical Chemistry
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2019 308 1
CYP450 activities before and after Roux-en-Y gastric bypass: correlation with their intestinal and liver contentSurgery for Obesity and Related Diseases
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2019 301 0
Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxinsBasic & Clinical Pharmacology & Toxicology
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2019 388 4
Preclinical Evaluation of Safety of Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus for Use in Cancer TreatmentIntegrative Cancer Therapies
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2019 313 105
Physiologically-based pharmacokinetic modeling for the prediction of CYP2D6-mediated gene-drug-drug interactionsCPT: pharmacometrics & systems pharmacology
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2019 331 192
Perioperative intravenous low-dose ketamine for neuropathic pain after major lower back surgery: A randomized, placebo-controlled studyEuropean Journal of Pain
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2019 322 2
Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modelingPediatric Research
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2019 263 2
Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active MetabolitesClinical Pharmacokinetics
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2018 566 589
Complex Drug-Drug-Gene-Disease Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical PerspectivesClinical Pharmacokinetics
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2018 438 593
Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory SettingJournal of Clinical Psychiatry
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2018 425 0
Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp softwareBiopharmaceutics & Drug Disposition
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2018 553 12
Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomesBasic & Clinical Pharmacology & Toxicology
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2018 410 324
Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term PerformanceTherapeutic Drug Monitoring
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2018 775 382
Severe and persistent morphine-induced respiratory depression associated with ATP-Binding Cassette Subfamily B Member 1 and catechol-O-methyltransferase genetic defects: A case reportEuropean Journal of Anaesthesiology
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2018 378 229
Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study)BMC Pharmacology & Toxicology
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2017 417 154
Impact of CYP2D6 functional allelic variations on phenoconversion and drug-drug interactionsClinical Pharmacology and Therapeutics
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2017 447 5
Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferasesJournal of pharmaceutical and biomedical analysis
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2017 573 527
Screening for genotypic and phenotypic variations in CYP450 activity in patients with therapeutic problems in a psychiatric setting, a retrospective studyPharmacological research
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2017 600 152
Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the futureClinical Pharmacology and Therapeutics
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2017 505 0
The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell TransplantationFrontiers in Pharmacology
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2017 531 211
Hepatocyte Concentrations of Indocyanin Green (ICG) Reflects Transfer Rates Across Membrane TransportersBasic & clinical pharmacology & toxicology
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2017 483 3
Plasma concentrations of transdermal fentanyl and buprenorphine in pigs (Sus scrofa domesticus)Veterinary Anaesthesia and Analgesia
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2017 421 1
Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized MedicineJournal of Pharmaceutical Sciences
2017 423 0
Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosisFree radical biology & medicine
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2016 602 243
An extensive cocktail approach for rapid risk assessment of in vitro CYP450 direct reversible inhibition by xenobiotic exposureToxicology and applied pharmacology
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2016 560 2
Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic DefectFrontiers in pharmacology
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2016 418 193
The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesiaNeuropharmacology
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2016 505 280
Detection of busulfan adducts on proteinsRCM. Rapid communications in mass spectrometry
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2016 587 97
Aspirin response: Differences in serum thromboxane B2 levels between clinical studiesPlatelets
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2016 635 1
Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approachClinical pharmacology and therapeutics
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2016 564 601
Pharmacogenomics of Oral Antithrombotic DrugsCurrent pharmaceutical design
2016 561 0
Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cellsFundamental & clinical pharmacology
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2016 549 21
Severe Vincristine-Induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case StudyClinical therapeutics
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2016 497 2
Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling MethodBasic & clinical pharmacology & toxicology
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2016 600 360
Markers of Individual Drug Metabolism: Towards the Development of a Personalized Antidepressant PrescriptionCurrent drug metabolism
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2015 535 3
Evidence-Based Choice of P2Y12 Inhibitors in End Stage Renal Disease Patients: A Mini-ReviewCurrent drug metabolism
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2015 580 6
Augmented renal clearance, low ß-lactam concentrations and clinical outcomes in the critically ill: An observational prospective cohort studyInternational journal of antimicrobial agents
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2015 740 3
GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteersPain
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2015 560 3
Prediction by pharmacogenetics of safety and efficacy of non-steroidal anti- inflammatory drugs: a reviewCurrent drug metabolism
2014 605 0
Incorporation of Flurbiprofen in a 4-Drug Cytochrome P450 Phenotyping CocktailBasic & clinical pharmacology & toxicology
accessLevelRestricted
2014 607 4
Phenotyping of CYP450 in human liver microsomes using the cocktail approachAnalytical & bioanalytical chemistry
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2014 450 2
Antiplatelet Therapy: Targeting the TxA2 PathwayJournal of cardiovascular translational research
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2014 573 2
Geneva Cocktail for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood SpotsClinical pharmacology and therapeutics
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2014 809 317
Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activityAIDS research and therapy
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2014 636 908
The association of cytochrome P450 genetic polymorphisms with sulfolane formation and the efficacy of a busulfan-based conditioning regimen in pediatric patients undergoing hematopoietic stem cell transplantationPharmacogenomics journal
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2014 603 8
Prediction of Metabolic Interactions With Oxycodone via CYP2D6 and CYP3A Inhibition Using a Physiologically Based Pharmacokinetic ModelCPT: pharmacometrics & systems pharmacology
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2014 557 225
Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasmaBioanalysis
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2014 691 5
Role of paraoxonase-1 in CYP2C19 loss-of-function carriersThrombosis research
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2014 592 0
A cocktail approach for assessing the in vitro activity of human cytochrome P450s: An overview of current methodologiesJournal of pharmaceutical and biomedical analysis
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2014 492 7
Antihyperalgesic Effect of the GABA(A) Ligand Clobazam in a Neuropathic Pain Model in Mice: A Pharmacokinetic-Pharmacodynamic StudyBasic & clinical pharmacology & toxicology
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2013 592 325
Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative propertiesArteriosclerosis, thrombosis, and vascular biology
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2013 604 0
Role of P-glycoprotein in the uptake/efflux transport of oral vitamin K antagonists and rivaroxaban through the Caco-2 cell modelBasic & clinical pharmacology & toxicology
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2013 537 3
Intraocular penetration of penciclovir after oral administration of famciclovir: a population pharmacokinetic modelThe journal of antimicrobial chemotherapy
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2013 535 0
Pharmacokinetic interaction between prasugrel and ritonavir in healthy volunteersBasic & clinical pharmacology & toxicology
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2013 574 375
Dual reuptake inhibitor milnacipran and spinal pain pathways in fibromyalgia patients: a randomized, double-blind, placebo-controlled trialPain physician
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2013 543 1 029
Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute painPain physician
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2013 704 627
Applications of CYP450 Testing in the Clinical SettingMolecular diagnosis & therapy
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2013 631 771
Evidence of Drug-Drug Interactions through Uptake and Efflux Transport Systems in Rat Hepatocytes: Implications for Cellular Concentrations of Competing DrugsDrug metabolism and disposition
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2013 739 621
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretionDiabetes
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2012 722 458
Transcriptional regulation of CYP2C19 and its role in altered enzyme activityCurrent drug metabolism
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2012 528 0
Serotonin syndrome following drug-drug interactions and CYP2D6 and CYP2C19 genetic polymorphisms in an HIV-infected patientAIDS
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2012 566 498
Validation of the simplified UVB model to assess the pharmacodynamics of analgesics in healthy human volunteersChimia
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2012 728 1 109
Pharmacokinetic-pharmacodynamic modelling of opioids in healthy human volunteers. A minireviewBasic & clinical pharmacology & toxicology
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2012 561 578
Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysisJournal of thrombosis and haemostasis
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2012 558 0
The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitroBritish journal of pharmacology
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2012 511 0
Oral flurbiprofen metabolic ratio assessment using a single-point dried blood spotClinical pharmacology and therapeutics
2012 564 0
Analgesics in patients with hepatic impairment: pharmacology and clinical implicationsDrugs
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2012 643 3
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infectionJournal of viral hepatitis
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2012 592 0
A simplified method for busulfan monitoring using dried blood spot in combination with liquid chromatography/tandem mass spectrometryRCM. Rapid communications in mass spectrometry
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2012 746 728
A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combinationBasic & clinical pharmacology & toxicology
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2011 637 0
Ritonavir inhibits the two main prasugrel bioactivation pathways in vitro: a potential drug-drug interaction in HIV patientsMetabolism, clinical and experimental
2011 589 0
HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic painNeuropharmacology
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2011 712 548
How organic anions accumulate in hepatocytes lacking Mrp2: evidence in rat liverThe Journal of pharmacology and experimental therapeutics
accessLevelPrivate
2011 551 0
Automated system for on-line desorption of dried blood spots applied to LC/MS/MS pharmacokinetic study of flurbiprofen and its metaboliteJournal of pharmaceutical and biomedical analysis
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2011 679 710
The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodoneBritish journal of pharmacology
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2010 677 2
Impact of genetic polymorphisms and drug-drug interactions on clopidogrel and prasugrel response variabilityCurrent drug metabolism
2010 606 0
Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safetyBritish journal of pharmacology
accessLevelRestricted
2010 545 1
Uptake/efflux transport of tramadol enantiomers and O-desmethyl-tramadol: focus on P-glycoproteinBasic & clinical pharmacology & toxicology
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2009 578 2
Two-dimensional liquid chromatography-ion trap mass spectrometry for the simultaneous determination of ketorolac enantiomers and paracetamol in human plasma: application to a pharmacokinetic studyJournal of chromatography
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2009 501 0
The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype predictionPharmacogenomics journal
accessLevelRestricted
2009 775 0
P-glycoprotein is not involved in the differential oral potency of naloxone and naltrexoneFundamental & clinical pharmacology
accessLevelRestricted
2009 593 0
Influence of ABCB1 gene polymorphisms and P-glycoprotein activity on cyclosporine pharmacokinetics in peripheral blood mononuclear cells in healthy volunteersDrug metabolism letters
2008