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Validation of the simplified UVB model to assess the pharmacodynamics of analgesics in healthy human volunteers

Published in Chimia. 2012, vol. 66, no. 5, p. 296-9
Abstract A pharmacokinetic/pharmacodynamic, randomized, crossover, placebo-controlled study was conducted in healthy human volunteers with the primary objective of exploring the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg intravenously on experimental pain models. Further, the simplified UVB model was validated as a screening tool for analgesics or a combination of analgesics in clinical drug development. It was observed that the UVB irradiation induced primary hyperalgesia, evidenced by significant decreases of the heat pain threshold from (mean ± SD) 46.9 ± 1.1 °C to 40.1 ± 1.7 °C (p <0.001) and of the mechanical pain threshold (62% decrease). A small intra- and inter-individual variability was observed as well as consistent intra-day stability for the heat pain threshold. The UVB irradiation also resulted in the development of an area of secondary hyperalgesia of 21.3 ± 11.3 cm(2). The mechanical pain threshold and area of secondary hyperalgesia showed small intra-individual variability and consistent intra-day stability. However, a greater variability was observed between subjects, which suggests that a crossover design would allow limiting the number of subjects.
Keywords Acetaminophen/pharmacokinetics/therapeutic useAdultAnalgesics/pharmacokinetics/therapeutic useAnalgesics, Non-Narcotic/pharmacokinetics/therapeutic useAnti-Inflammatory Agents, Non-Steroidal/pharmacokinetics/therapeutic useCross-Over StudiesDouble-Blind MethodDrug CombinationsFeasibility StudiesHumansHyperalgesia/drug therapyInjections, IntravenousKetorolac/pharmacokinetics/therapeutic useMaleMiddle AgedModels, BiologicalPain MeasurementPain Threshold/drug effectsSunburn/drug therapy/metabolismUltraviolet Rays/adverse effectsYoung Adult
PMID: 22867539
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Article (Published version) (338 Kb) - public document Free access
Research groups Pharmaco-omiques et médecine de précision (1003)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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ING LORENZINI, Kuntheavy et al. Validation of the simplified UVB model to assess the pharmacodynamics of analgesics in healthy human volunteers. In: Chimia, 2012, vol. 66, n° 5, p. 296-9. doi: 10.2533/chimia.2012.296 https://archive-ouverte.unige.ch/unige:27160

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Deposited on : 2013-04-03

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