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Title

Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data

Authors
Neyshaburinezhad, Navid
Ghasim, Hengameh
Rouini, Mohammadreza
Ardakani, Yalda H
Published in Journal of personalized medicine. 2021, vol. 11, no. 8, 804
Abstract Genetic polymorphisms in cytochrome P450 genes can cause alteration in metabolic activity of clinically important medicines. Thus, single nucleotide variants (SNVs) and copy number variations (CNVs) in CYP genes are leading factors of drug pharmacokinetics and toxicity and form pharmacogenetics biomarkers for drug dosing, efficacy, and safety. The distribution of cytochrome P450 alleles differs significantly between populations with important implications for personalized drug therapy and healthcare programs. To provide a meta-analysis of CYP allele polymorphisms with clinical importance, we brought together whole-genome and exome sequencing data from 800 unrelated individuals of Iranian population (100 subjects from 8 major ethnics of Iran) and 63,269 unrelated individuals of five major human populations (EUR, AMR, AFR, EAS and SAS). By integrating these datasets with population-specific linkage information, we evolved the frequencies of 140 CYP haplotypes related to 9 important CYP450 isoenzymes (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4 and CYP3A5) giving a large resource for major genetic determinants of drug metabolism. Furthermore, we evaluated the more frequent Iranian alleles and compared the dataset with the Caucasian race. Finally, the similarity of the Iranian population SNVs with other populations was investigated.
Keywords CYP450 enzymesIranian populationGenetic polymorphismMetabolismPersonalized medicine
Identifiers
PMID: 34442448
PMCID: PMC8401584
Full text
Article (Published version) (2.2 MB) - public document Free access
Appendix (193 Kb) - public document Free access
Other version: https://www.mdpi.com/2075-4426/11/8/804/htm
Structures
Research groups Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Pharmaco-omiques et médecine de précision (1003)
Project
National Institute for Medical Research Development of Iran (NIMAD): 973068
Citation
(ISO format)
NEYSHABURINEZHAD, Navid et al. Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data. In: Journal of personalized medicine, 2021, vol. 11, n° 8, p. 804. doi: 10.3390/jpm11080804 https://archive-ouverte.unige.ch/unige:161644

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Deposited on : 2022-06-23

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