Dual reuptake inhibitor milnacipran and spinal pain pathways in fibromyalgia patients: a randomized, double-blind, placebo-controlled trial

Matthey, Alain; Cedraschi, Christine; Piguet, Valérie; Besson, Marie; Chabert, Jocelyne; Daali, Youssef; Courvoisier, Delphine; Montagne, Agnes; Dayer, Pierre; Desmeules, Jules Alexandre

Scientific article

English

Dual reuptake inhibitor milnacipran and spinal pain pathways in fibromyalgia patients: a randomized, double-blind, placebo-controlled trial

Contributors

Matthey, Alain; Cedraschi, Christine; Piguet, Valérie; Besson, Marie; Chabert, Jocelyne; Daali, Youssef; Courvoisier, Delphine

; Montagne, Agnes; Dayer, Pierre; Desmeules, Jules Alexandre

Published in

Pain physician, vol. 16, no. 5, p. E553-562

Publication date

2013

Abstract

Investigations based on quantitative sensory testing have consistently shown evidence of allodynia in fibromyalgia syndrome (FMS) patients involving both the spinal and supraspinal pain regulatory systems. Functional imaging studies have demonstrated enhanced neural activities in pain-related brain areas as well as impairment of pain inhibition in the descending nociceptive regulatory system. A higher state of excitability of spinal nociceptive neurons as evidenced by lowered nociceptive flexion reflex R-III (NFR) threshold was reported for FMS patients. The NFR procedure has been shown to be a valuable tool to evaluate pharmacologically active therapeutic agents at the spinal level.

Keywords

Adult
Aged
Antidepressive Agents/administration & dosage/therapeutic use
Cyclopropanes/administration & dosage/therapeutic use
Double-Blind Method
Female
Fibromyalgia/drug therapy
Humans
Male
Middle Aged
Pain/drug therapy
Pain Measurement/methods
Spinal Diseases/drug therapy
Treatment Outcome

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

MATTHEY, Alain et al. Dual reuptake inhibitor milnacipran and spinal pain pathways in fibromyalgia patients: a randomized, double-blind, placebo-controlled trial. In: Pain physician, 2013, vol. 16, n° 5, p. E553–562.

Article (Published version)

Identifiers

PID : unige:42493
PMID : 24077206

Journal ISSN

1533-3159

642views

1179downloads

Creation

24/11/2014 13:02:00

First validation

24/11/2014 13:02:00

Update

14/03/2023 22:20:50

Status update

14/03/2023 22:20:50

Last indexation

30/10/2024 21:02:32

Dual reuptake inhibitor milnacipran and spinal pain pathways in fibromyalgia patients: a randomized, double-blind, placebo-controlled trial

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation