Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety
Published inBritish journal of pharmacology, vol. 160, no. 4, p. 919-930
Publication date2010
Abstract
Keywords
- Adult
- Analgesics, Opioid/adverse effects/pharmacokinetics/pharmacology/*therapeutic use
- Cross-Over Studies
- Cytochrome P-450 CYP2D6/antagonists & inhibitors/*genetics/*metabolism
- Cytochrome P-450 CYP3A/antagonists & inhibitors/*metabolism
- Double-Blind Method
- Drug Interactions
- Enzyme Inhibitors/pharmacology
- Genotype
- Humans
- Male
- Metabolic Detoxication, Phase I/genetics
- Middle Aged
- Oxycodone/*adverse effects/pharmacokinetics/pharmacology/*therapeutic use
- Oxymorphone/blood
- Pain Threshold/drug effects
- Phenotype
- *Polymorphism, Genetic
- Psychomotor Performance/drug effects
- Reflex, Pupillary/drug effects
- Young Adult
Affiliation entities
- Faculté des sciences / Section des sciences pharmaceutiques
- Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
- Faculté de médecine / Section de médecine clinique / Département de médecine
- Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences
Citation (ISO format)
SAMER, Caroline Flora et al. Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety. In: British journal of pharmacology, 2010, vol. 160, n° 4, p. 919–930. doi: 10.1111/j.1476-5381.2010.00709.x
Main files (1)
Article
Identifiers
- PID : unige:21282
- DOI : 10.1111/j.1476-5381.2010.00709.x
- PMID : 20590588
ISSN of the journal0007-1188