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Scientific article
English

Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients

Published inJournal of Thrombosis and Haemostasis, vol. 18, no. 6, p. 1425-1434
Publication date2020
Abstract

On-clopidogrel platelet reactivity (PR) is associated with the risk of thrombotic or bleeding event in selected populations of high-risk patients. PR is a highly heritable phenotype and a few variants of cytochrome genes, essentially CYP2C19, are associated with PR but only explain 5% to 12% of the variability.

Keywords
  • Clopidogrel
  • Drug response
  • Exome sequencing
  • Network analysis
  • Platelet reactivity
Citation (ISO format)
FONTANA, Pierre et al. Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients. In: Journal of Thrombosis and Haemostasis, 2020, vol. 18, n° 6, p. 1425–1434. doi: 10.1111/jth.14776
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1538-7836
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Technical informations

Creation11/13/2020 11:01:00 AM
First validation11/13/2020 11:01:00 AM
Update time03/16/2023 12:06:35 AM
Status update03/16/2023 12:06:34 AM
Last indexation05/06/2024 6:42:42 AM
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