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Title

Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites

Authors
Ancrenaz-Sirot, Virginie
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Published in Clinical Pharmacokinetics. 2018, vol. 57, no. 10, p. 1347-1354
Abstract Prasugrel and clopidogrel are inhibitors of the ADP-P2Y12 platelet receptor used in acute coronary syndrome patients. They require bioactivation via isoenzymes such as cytochrome P450 (CYP) 3A4, CYP2C19 and CYP2B6. Ritonavir and cobicistat are potent CYP3A inhibitors, prescribed as pharmacokinetic (PK) enhancers in the treatment of human immunodeficiency virus (HIV) infection.
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PMID: 29453687
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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MARSOUSI, Niloufar et al. Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites. In: Clinical Pharmacokinetics, 2018, vol. 57, n° 10, p. 1347-1354. https://archive-ouverte.unige.ch/unige:111012

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Deposited on : 2018-11-20

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