en
Scientific article
English

Development and validation of liquid chromatography and capillary electrophoresis methods for acarbose determination in pharmaceutical tablets

Published inJournal of pharmaceutical and biomedical analysis, vol. 18, no. 4-5, p. 729-735
Publication date1998
Abstract

Liquid chromatography and capillary zone electrophoresis, respectively coupled to an evaporative light scattering detector and a UV detector have been developed for the analysis of acarbose without any derivatization procedure. The electrophoretic separation of acarbose anomers was achieved through the manipulation of the working temperature. Both methods were validated and showed good validation data in terms of precision, accuracy and linearity. The validated methods were successfully applied to the dosage of acarbose in commercially available Glucobay tablets.

Keywords
  • Acarbose
  • Chromatography, Liquid/methods
  • Electrophoresis, Capillary/methods
  • Hypoglycemic Agents/analysis
  • Reproducibility of Results
  • Tablets/chemistry
  • Temperature
  • Trisaccharides/analysis
Citation (ISO format)
CHERKAOUI, Samir et al. Development and validation of liquid chromatography and capillary electrophoresis methods for acarbose determination in pharmaceutical tablets. In: Journal of pharmaceutical and biomedical analysis, 1998, vol. 18, n° 4-5, p. 729–735. doi: 10.1016/s0731-7085(98)00216-7
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Article (Published version)
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Identifiers
ISSN of the journal0731-7085
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Technical informations

Creation06/22/2010 1:50:00 PM
First validation06/22/2010 1:50:00 PM
Update time03/14/2023 3:49:17 PM
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