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Title

Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory Setting

Authors
Lloret-Linares, Célia
Heron, Kyle
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Published in Journal of Clinical Psychiatry. 2018, vol. 79, no. 2
Abstract Drug-metabolizing enzymes (DMEs), such as cytochrome P450 (CYP) enzymes, and transporters have emerged as major determinants of variability in drug metabolism and response. This study investigated the association between CYP and P-glycoprotein activities and plasma antidepressant concentration in an outpatient clinical setting. Secondary outcomes were antidepressant efficacy and tolerance. We also describe phenotypes in patients treated with antidepressants and evaluate the tolerance of a minimally invasive phenotyping approach.
Identifiers
PMID: 29570971
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Article (Published version) (249 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Pharmaco-omiques et médecine de précision (1003)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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LLORET-LINARES, Célia et al. Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory Setting. In: Journal of Clinical Psychiatry, 2018, vol. 79, n° 2. https://archive-ouverte.unige.ch/unige:115534

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Deposited on : 2019-04-01

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