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Scientific article
English

Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory Setting

Published inJournal of Clinical Psychiatry, vol. 79, no. 2
Publication date2018
Abstract

Drug-metabolizing enzymes (DMEs), such as cytochrome P450 (CYP) enzymes, and transporters have emerged as major determinants of variability in drug metabolism and response. This study investigated the association between CYP and P-glycoprotein activities and plasma antidepressant concentration in an outpatient clinical setting. Secondary outcomes were antidepressant efficacy and tolerance. We also describe phenotypes in patients treated with antidepressants and evaluate the tolerance of a minimally invasive phenotyping approach.

Citation (ISO format)
LLORET-LINARES, Célia et al. Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory Setting. In: Journal of Clinical Psychiatry, 2018, vol. 79, n° 2. doi: 10.4088/JCP.16m11387
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ISSN of the journal0160-6689
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Creation11/12/2018 3:18:00 PM
First validation11/12/2018 3:18:00 PM
Update time03/15/2023 4:04:14 PM
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