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Title

Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance

Authors
Uppugunduri, Chakradhara Rao Satyanarayana
Peters, Christina
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Published in Therapeutic Drug Monitoring. 2018, vol. 40, no. 1, p. 84-92
Abstract Busulfan (Bu) is an alkylating agent used as part of the conditioning regimen in pediatric patients before hematopoietic stem cell transplantation. Despite intravenous (IV) administration and dosing recommendations based on age and weight, reports have revealed interindividual variability in Bu pharmacokinetics and the outcomes of hematopoietic stem cell transplantation. In this context, adjusting doses to Bu's narrow therapeutic window is advised. We aimed to assess the utility of therapeutic drug monitoring (TDM) of Bu in children, the reliability of Bu quantification methods, and its stability in plasma when stored for up to 5 years.
Keywords Alkylating Agents/blood/pharmacokineticsBusulfan/blood/pharmacokineticsChildChromatography, High Pressure Liquid/methodsDose-Response Relationship, DrugDrug Monitoring/methodsDrug StabilityHematopoietic Stem Cell Transplantation/methodsHumansQuality ControlReproducibility of ResultsTandem Mass Spectrometry/methodsTime Factors
Identifiers
PMID: 29189665
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Article (Published version) (566 Kb) - public document Free access
Structures
Research groups Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
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CHOONG, Eva et al. Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance. In: Therapeutic Drug Monitoring, 2018, vol. 40, n° 1, p. 84-92. https://archive-ouverte.unige.ch/unige:111766

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Deposited on : 2018-12-03

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