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Title

Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins

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Published in Basic & Clinical Pharmacology & Toxicology. 2019
Abstract Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) is the most toxic congener of a family of structurally and mechanistically related persistent organic pollutants whose effects are mediated through the aryl hydrocarbon receptor (AhR). Induction of CYP1A1/2 by TCDD through the AhR depends on the magnitude and the duration of exposure. We aimed to assess CYP1A2 activity after acute and chronic exposure to TCDD. The Maincy cohort is a sample population from Melun in the Val-de-Seine region in France that lived for at least 5 years close to a waste incinerator emitting polluted vapours (1974-2002) with high concentrations of dioxins (up to 2000 times the maximal recommended values). Acute exposure to TCDD (Viktor Yushchenko) has been described elsewhere by Sorg et al (Toxicol. Sci. 2012; 125:310-317). Both are rare cases of well-identified source of chronic and acute exposure to TCDD.
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PMID: 31608602
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Research groups Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
La recherche en biochimie dermatologique (652)
Pharmaco-omiques et médecine de précision (1003)
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SAMER, Caroline Flora et al. Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins. In: Basic & Clinical Pharmacology & Toxicology, 2019. doi: 10.1111/bcpt.13339 https://archive-ouverte.unige.ch/unige:128196

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Deposited on : 2019-12-23

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