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Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain

ContributorsEhret, Georg Benedikt; Daali, Youssef; Chabert, Jocelyne; Rebsamen, Michela; Wolff, Adriana; Forster, Alain; Moursli, Fouzia; Fritschy, Daniel; Rossier, Michel; Piguet, Valérie; Dayer, Pierre; Gex-Fabry, Marianne; Desmeules, Jules Alexandre
Published inPain physician, vol. 16, no. 1, p. 45-56
Publication date2013
Abstract

There is some evidence that dextromethorphan (DM) is effective as a preemptive analgesic agent.  DM is mainly metabolized to dextrorphan (DOR) by CYP2D6 whose activity can be inhibited by pharmacologic intervention.

Keywords
  • Pre-emptive analgesia
  • Dextomethorphan
  • Population kinetics
  • Quinidine
  • Cytochrome 2D6
Affiliation entities
Research groups
Funding
  • Autre - Fonds APSI - HUG
Citation (ISO format)
EHRET, Georg Benedikt et al. Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain. In: Pain physician, 2013, vol. 16, n° 1, p. 45–56.
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Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN1533-3159
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791downloads

Technical informations

Creation12/03/2013 14:49:00
First validation12/03/2013 14:49:00
Update14/03/2023 20:07:00
Status update14/03/2023 20:06:59
Last indexation30/10/2024 09:07:49
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