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Title

Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain

Authors
Moursli, Fouzia
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Published in Pain Physician. 2013, vol. 16, no. 1, p. 45-56
Abstract There is some evidence that dextromethorphan (DM) is effective as a preemptive analgesic agent.  DM is mainly metabolized to dextrorphan (DOR) by CYP2D6 whose activity can be inhibited by pharmacologic intervention.
Keywords Pre-emptive analgesiaDextomethorphanPopulation kineticsQuinidineCytochrome 2D6
Identifiers
PMID: 23340533
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Article (Published version) (469 Kb) - public document Free access
Structures
Research groups Chirurgie orthopédique et traumatologique (98)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Biologie du myocarde (22)
Project Fonds APSI - HUG
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(ISO format)
EHRET, Georg Benedikt et al. Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain. In: Pain Physician, 2013, vol. 16, n° 1, p. 45-56. https://archive-ouverte.unige.ch/unige:27152

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Deposited on : 2013-04-03

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