Title |
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Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties
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Authors | | Khanicheh, Elham Qi, Yue Xie, Aris Mitterhuber, Martina Xu, Lifen Mochizuki, Michika Ruggeri, Zaverio M Kuster, Gabriela M Lindner, Jonathan R Kaufmann, Beat A show all authors [1 - 13]
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Published in |
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Arteriosclerosis, thrombosis, and vascular biology. 2013, vol. 33, no. 9, p. 2187-92 |
Abstract |
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Antioxidative drugs continue to be developed for the treatment of atherosclerosis. Apocynin is an nicotinamide adenine dinucleotide phosphate oxidase inhibitor with anti-inflammatory properties. We used contrast-enhanced ultrasound molecular imaging to assess whether short-term apocynin therapy in atherosclerosis reduces vascular oxidative stress and endothelial activation |
Keywords |
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Acetophenones/pharmacology — Animals — Anti-Inflammatory Agents/pharmacology — Antioxidants/pharmacology — Aortic Diseases/drug therapy/genetics/metabolism/pathology/ultrasonography — Atherosclerosis/drug therapy/genetics/metabolism/pathology/ultrasonography — Biological Markers/metabolism — Blotting, Western — Contrast Media/diagnostic use — Cytidine Deaminase/deficiency/genetics — Disease Models, Animal — Endothelium, Vascular/drug effects/metabolism/pathology/ultrasonography — Enzyme Inhibitors/pharmacology — Macrophages/drug effects/metabolism — Male — Mice — Mice, Inbred C57BL — Mice, Knockout — Microbubbles — Molecular Imaging/methods — NADPH Oxidase/antagonists & inhibitors/metabolism — Oxidative Stress/drug effects — Phenotype — Platelet Adhesiveness/drug effects — Platelet Glycoprotein GPIb-IX Complex/metabolism — Receptors, LDL/genetics/metabolism — Superoxides/metabolism — Time Factors — Ultrasonography, Interventional — Vascular Cell Adhesion Molecule-1/metabolism |
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Full text |
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Article (Published version) (1.5 MB) -  Limited access to UNIGE
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Research groups | | Groupe Desmeules Jules (pharmacologie/toxicologie) (567) Pharmaco-omiques et médecine de précision (1003) Radicaux libres et cellules souches embryonnaires (60) |
Citation (ISO format) | | KHANICHEH, Elham et al. Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties. In: Arteriosclerosis, thrombosis, and vascular biology, 2013, vol. 33, n° 9, p. 2187-92. doi: 10.1161/ATVBAHA.113.301710 https://archive-ouverte.unige.ch/unige:32479 |