Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties

Khanicheh, Elham; Qi, Yue; Xie, Aris; Mitterhuber, Martina; Xu, Lifen; Mochizuki, Michika; Daali, Youssef; Jaquet, Vincent; Krause, Karl-Heinz; Ruggeri, Zaverio M; Kuster, Gabriela M; Lindner, Jonathan R; Kaufmann, Beat A

doi:10.1161/ATVBAHA.113.301710

Scientific article

English

Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties

ContributorsKhanicheh, Elham; Qi, Yue; Xie, Aris; Mitterhuber, Martina; Xu, Lifen; Mochizuki, Michika; Daali, Youssef; Jaquet, Vincent; Krause, Karl-Heinz; Ruggeri, Zaverio M; Kuster, Gabriela M; Lindner, Jonathan R; Kaufmann, Beat A

Published inArteriosclerosis, thrombosis, and vascular biology, vol. 33, no. 9, p. 2187-2192

Publication date2013

Abstract

Antioxidative drugs continue to be developed for the treatment of atherosclerosis. Apocynin is an nicotinamide adenine dinucleotide phosphate oxidase inhibitor with anti-inflammatory properties. We used contrast-enhanced ultrasound molecular imaging to assess whether short-term apocynin therapy in atherosclerosis reduces vascular oxidative stress and endothelial activation

Keywords

Acetophenones/pharmacology
Animals
Anti-Inflammatory Agents/pharmacology
Antioxidants/pharmacology
Aortic Diseases/drug therapy/genetics/metabolism/pathology/ultrasonography
Atherosclerosis/drug therapy/genetics/metabolism/pathology/ultrasonography
Biological Markers/metabolism
Blotting, Western
Contrast Media/diagnostic use
Cytidine Deaminase/deficiency/genetics
Disease Models, Animal
Endothelium, Vascular/drug effects/metabolism/pathology/ultrasonography
Enzyme Inhibitors/pharmacology
Macrophages/drug effects/metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbubbles
Molecular Imaging/methods
NADPH Oxidase/antagonists & inhibitors/metabolism
Oxidative Stress/drug effects
Phenotype
Platelet Adhesiveness/drug effects
Platelet Glycoprotein GPIb-IX Complex/metabolism
Receptors, LDL/genetics/metabolism
Superoxides/metabolism
Time Factors
Ultrasonography, Interventional
Vascular Cell Adhesion Molecule-1/metabolism

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research group

Citation (ISO format)

KHANICHEH, Elham et al. Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties. In: Arteriosclerosis, thrombosis, and vascular biology, 2013, vol. 33, n° 9, p. 2187–2192. doi: 10.1161/ATVBAHA.113.301710

Article (Published version)

Identifiers

PID : unige:32479
DOI : 10.1161/ATVBAHA.113.301710
PMID : 23908248

ISSN of the journal1079-5642

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Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties

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