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Scientific article
English

Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties

Published inArteriosclerosis, thrombosis, and vascular biology, vol. 33, no. 9, p. 2187-2192
Publication date2013
Abstract

Antioxidative drugs continue to be developed for the treatment of atherosclerosis. Apocynin is an nicotinamide adenine dinucleotide phosphate oxidase inhibitor with anti-inflammatory properties. We used contrast-enhanced ultrasound molecular imaging to assess whether short-term apocynin therapy in atherosclerosis reduces vascular oxidative stress and endothelial activation

Keywords
  • Acetophenones/pharmacology
  • Animals
  • Anti-Inflammatory Agents/pharmacology
  • Antioxidants/pharmacology
  • Aortic Diseases/drug therapy/genetics/metabolism/pathology/ultrasonography
  • Atherosclerosis/drug therapy/genetics/metabolism/pathology/ultrasonography
  • Biological Markers/metabolism
  • Blotting, Western
  • Contrast Media/diagnostic use
  • Cytidine Deaminase/deficiency/genetics
  • Disease Models, Animal
  • Endothelium, Vascular/drug effects/metabolism/pathology/ultrasonography
  • Enzyme Inhibitors/pharmacology
  • Macrophages/drug effects/metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microbubbles
  • Molecular Imaging/methods
  • NADPH Oxidase/antagonists & inhibitors/metabolism
  • Oxidative Stress/drug effects
  • Phenotype
  • Platelet Adhesiveness/drug effects
  • Platelet Glycoprotein GPIb-IX Complex/metabolism
  • Receptors, LDL/genetics/metabolism
  • Superoxides/metabolism
  • Time Factors
  • Ultrasonography, Interventional
  • Vascular Cell Adhesion Molecule-1/metabolism
Citation (ISO format)
KHANICHEH, Elham et al. Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties. In: Arteriosclerosis, thrombosis, and vascular biology, 2013, vol. 33, n° 9, p. 2187–2192. doi: 10.1161/ATVBAHA.113.301710
Main files (1)
Article (Published version)
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Identifiers
ISSN of the journal1079-5642
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Creation11/19/2013 6:33:00 PM
First validation11/19/2013 6:33:00 PM
Update time03/14/2023 8:45:38 PM
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