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Title

Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties

Authors
Khanicheh, Elham
Qi, Yue
Xie, Aris
Mitterhuber, Martina
Xu, Lifen
Mochizuki, Michika
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Published in Arteriosclerosis, Thrombosis, and Vascular Biology. 2013, vol. 33, no. 9, p. 2187-92
Abstract Antioxidative drugs continue to be developed for the treatment of atherosclerosis. Apocynin is an nicotinamide adenine dinucleotide phosphate oxidase inhibitor with anti-inflammatory properties. We used contrast-enhanced ultrasound molecular imaging to assess whether short-term apocynin therapy in atherosclerosis reduces vascular oxidative stress and endothelial activation
Keywords Acetophenones/pharmacologyAnimalsAnti-Inflammatory Agents/pharmacologyAntioxidants/pharmacologyAortic Diseases/drug therapy/genetics/metabolism/pathology/ultrasonographyAtherosclerosis/drug therapy/genetics/metabolism/pathology/ultrasonographyBiological Markers/metabolismBlotting, WesternContrast Media/diagnostic useCytidine Deaminase/deficiency/geneticsDisease Models, AnimalEndothelium, Vascular/drug effects/metabolism/pathology/ultrasonographyEnzyme Inhibitors/pharmacologyMacrophages/drug effects/metabolismMaleMiceMice, Inbred C57BLMice, KnockoutMicrobubblesMolecular Imaging/methodsNADPH Oxidase/antagonists & inhibitors/metabolismOxidative Stress/drug effectsPhenotypePlatelet Adhesiveness/drug effectsPlatelet Glycoprotein GPIb-IX Complex/metabolismReceptors, LDL/genetics/metabolismSuperoxides/metabolismTime FactorsUltrasonography, InterventionalVascular Cell Adhesion Molecule-1/metabolism
Identifiers
PMID: 23908248
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Article (Published version) (1.5 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Radicaux libres et cellules souches embryonnaires (60)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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KHANICHEH, Elham et al. Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, vol. 33, n° 9, p. 2187-92. https://archive-ouverte.unige.ch/unige:32479

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Deposited on : 2013-12-18

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