Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties

Khanicheh, Elham; Qi, Yue; Xie, Aris; Mitterhuber, Martina; Xu, Lifen; Mochizuki, Michika; Daali, Youssef; Jaquet, Vincent; Krause, Karl-Heinz; Ruggeri, Zaverio M; Kuster, Gabriela M; Lindner, Jonathan R; Kaufmann, Beat A

doi:10.1161/ATVBAHA.113.301710

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Title		Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties
Authors		Khanicheh, Elham Qi, Yue Xie, Aris Mitterhuber, Martina Xu, Lifen Mochizuki, Michika Daali, Youssef Jaquet, Vincent Krause, Karl-Heinz Ruggeri, Zaverio M Kuster, Gabriela M Lindner, Jonathan R Kaufmann, Beat A show all authors [1 - 13]
Published in		Arteriosclerosis, thrombosis, and vascular biology. 2013, vol. 33, no. 9, p. 2187-92
Abstract		Antioxidative drugs continue to be developed for the treatment of atherosclerosis. Apocynin is an nicotinamide adenine dinucleotide phosphate oxidase inhibitor with anti-inflammatory properties. We used contrast-enhanced ultrasound molecular imaging to assess whether short-term apocynin therapy in atherosclerosis reduces vascular oxidative stress and endothelial activation
Keywords		Acetophenones/pharmacology — Animals — Anti-Inflammatory Agents/pharmacology — Antioxidants/pharmacology — Aortic Diseases/drug therapy/genetics/metabolism/pathology/ultrasonography — Atherosclerosis/drug therapy/genetics/metabolism/pathology/ultrasonography — Biological Markers/metabolism — Blotting, Western — Contrast Media/diagnostic use — Cytidine Deaminase/deficiency/genetics — Disease Models, Animal — Endothelium, Vascular/drug effects/metabolism/pathology/ultrasonography — Enzyme Inhibitors/pharmacology — Macrophages/drug effects/metabolism — Male — Mice — Mice, Inbred C57BL — Mice, Knockout — Microbubbles — Molecular Imaging/methods — NADPH Oxidase/antagonists & inhibitors/metabolism — Oxidative Stress/drug effects — Phenotype — Platelet Adhesiveness/drug effects — Platelet Glycoprotein GPIb-IX Complex/metabolism — Receptors, LDL/genetics/metabolism — Superoxides/metabolism — Time Factors — Ultrasonography, Interventional — Vascular Cell Adhesion Molecule-1/metabolism
Identifiers		DOI: 10.1161/ATVBAHA.113.301710 PMID: 23908248
Full text		Article (Published version) (1.5 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research groups		Groupe Desmeules Jules (pharmacologie/toxicologie) (567) Pharmaco-omiques et médecine de précision (1003) Radicaux libres et cellules souches embryonnaires (60)
Citation (ISO format)		KHANICHEH, Elham et al. Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties. In: Arteriosclerosis, thrombosis, and vascular biology, 2013, vol. 33, n° 9, p. 2187-92. doi: 10.1161/ATVBAHA.113.301710 https://archive-ouverte.unige.ch/unige:32479