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Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study)

Lloret-Linares, Célia
Chevret, Sylvie
Nieto, Isabelle
Molière, Fanny
Courtet, Philippe
Galtier, Florence
Richieri, Raphaëlle-Marie
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Published in BMC Pharmacology & Toxicology. 2017, vol. 18, no. 1, 70
Abstract It is well known that the standard doses of a given drug may not have equivalent effects in all patients. To date, the management of depression remains mainly empirical and often poorly evaluated. The development of a personalized medicine in psychiatry may reduce treatment failure, intolerance or resistance, and hence the burden and costs of mood depressive disorders. The Geneva Cocktail Phenotypic approach presents several advantages including the "in vivo" measure of different cytochromes and transporter P-gp activities, their simultaneous determination in a single test, avoiding the influence of variability over time on phenotyping results, the administration of low dose substrates, a limited sampling strategy with an analytical method developed on DBS analysis. The goal of this project is to explore the relationship between the activity of drug-metabolizing enzymes (DME), assessed by a phenotypic approach, and the concentrations of Venlafaxine (VLX) + O-demethyl-venlafaxine (ODV), the efficacy and tolerance of VLX.
Keywords ATP-Binding CassetteSub-Family BMember 1/metabolismAdolescentAdultAgedAged80 and overAntidepressive AgentsSecond-Generation/blood/pharmacokinetics/therapeutic useCytochrome P-450 CYP2C19/metabolismCytochrome P-450 CYP2D6/metabolismCytochrome P-450 CYP3A/metabolismDepressive DisorderMajor/drug therapy/metabolismFemaleFranceGenotypeHumansMaleMiddle AgedPhenotypeSwitzerlandTreatment OutcomeVenlafaxine Hydrochloride/blood/pharmacokinetics/therapeutic useYoung Adult
PMID: 29115994
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Research groups Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Pharmaco-omiques et médecine de précision (1003)
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LLORET-LINARES, Célia et al. Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study). In: BMC Pharmacology & Toxicology, 2017, vol. 18, n° 1, p. 70. doi: 10.1186/s40360-017-0173-2 https://archive-ouverte.unige.ch/unige:111045

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Deposited on : 2018-11-21

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