Severe Vincristine-Induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study

Bosilkovska Weisskopf, Marija; Ing Lorenzini, Kuntheavy; Uppugunduri Satyanarayana, Chakradhara Rao; Desmeules, Jules Alexandre; Daali, Youssef; Escher, Monica

doi:10.1016/j.clinthera.2015.10.017

Scientific article

English

Severe Vincristine-Induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study

Contributors

Bosilkovska Weisskopf, Marija; Ing Lorenzini, Kuntheavy

; Uppugunduri Satyanarayana, Chakradhara Rao

; Desmeules, Jules Alexandre; Daali, Youssef; Escher, Monica

Published in

Clinical therapeutics, vol. 38, no. 1, p. 216-220

Publication date

2016

Abstract

Peripheral neuropathy is a frequent vincristine-induced adverse effect. Vincristine is a substrate of P-glycoprotein and is metabolized by the cytochrome P-450 (CYP) 3A5 and 3A4 isoforms, with CYP3A5 contributing to 75% of the intrinsic clearance of vincristine. Alterations in the function of these proteins may lead to an increase in vincristine toxicity. CYP3A5 nonexpressor status has been associated with vincristine-induced peripheral neuropathy. The severity of neuropathy has been reported to be inversely correlated to vincristine metabolite concentrations. Recently, the presence of a mutation in the CEP72 gene, which encodes for a protein involved in microtubule formation, has also been associated with vincristine-induced peripheral neuropathy. However, a clear correlation between genetic polymorphisms and vincristine toxicity has not been established.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BOSILKOVSKA WEISSKOPF, Marija et al. Severe Vincristine-Induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study. In: Clinical therapeutics, 2016, vol. 38, n° 1, p. 216–220. doi: 10.1016/j.clinthera.2015.10.017

Article (Published version)

Identifiers

PID : unige:78730
DOI : 10.1016/j.clinthera.2015.10.017
PMID : 26565076

Journal ISSN

0149-2918

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11/12/2015 15:21:00

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11/12/2015 15:21:00

Update

14/03/2023 23:59:11

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14/03/2023 23:59:11

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31/10/2024 02:19:11

Severe Vincristine-Induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study

Contributors

Published in

Publication date

Abstract

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UNIGE research groups

Citation (ISO format)

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Technical informations

Creation

First validation

Update

Status update

Last indexation