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Title

The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro

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Published in British Journal of Pharmacology. 2012, vol. 166, no. 8, p. 2362-70
Abstract Clopidogrel is a prodrug bioactivated by cytochrome P450s (CYPs). More recently, paraoxonase-1 (PON1) has been proposed as a major contributor to clopidogrel metabolism. The purpose of this study was to assess the relative contribution of CYPs and PON1 to clopidogrel metabolism in vitro.
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PMID: 22428615
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Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research groups Geneva Platelet Group (13)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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(ISO format)
ANCRENAZ, Virginie et al. The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro. In: British Journal of Pharmacology, 2012, vol. 166, n° 8, p. 2362-70. https://archive-ouverte.unige.ch/unige:26343

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Deposited on : 2013-02-11

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