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Title

The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro
Authors
Ancrenaz, Virginie
Desmeules, Jules Alexandre
James, Richard William
Fontana, Pierre
Reny, Jean-Luc
Dayer, Pierre
Daali, Youssef
Published in British Journal of Pharmacology. 2012, vol. 166, no. 8, p. 2362-70
Abstract Clopidogrel is a prodrug bioactivated by cytochrome P450s (CYPs). More recently, paraoxonase-1 (PON1) has been proposed as a major contributor to clopidogrel metabolism. The purpose of this study was to assess the relative contribution of CYPs and PON1 to clopidogrel metabolism in vitro.
Identifiers
PMID: 22428615
Full text
Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie et soins intensifs
Faculté des sciences / Section des sciences pharmaceutiques
Research groups Geneva Platelet Group (13)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Citation
(ISO format) 		ANCRENAZ, Virginie et al. The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro. In: British Journal of Pharmacology, 2012, vol. 166, n° 8, p. 2362-70. https://archive-ouverte.unige.ch/unige:26343

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Deposited on : 2013-02-11

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