The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro

Ancrenaz, Virginie; Desmeules, Jules Alexandre; James, Richard William; Fontana, Pierre; Reny, Jean-Luc; Dayer, Pierre; Daali, Youssef

doi:10.1111/j.1476-5381.2012.01946.x

Scientific article

English

The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro

ContributorsAncrenaz, Virginie; Desmeules, Jules Alexandre; James, Richard William; Fontana, Pierre; Reny, Jean-Luc

; Dayer, Pierre; Daali, Youssef

Published inBritish journal of pharmacology, vol. 166, no. 8, p. 2362-2370

Publication date2012

Abstract

Clopidogrel is a prodrug bioactivated by cytochrome P450s (CYPs). More recently, paraoxonase-1 (PON1) has been proposed as a major contributor to clopidogrel metabolism. The purpose of this study was to assess the relative contribution of CYPs and PON1 to clopidogrel metabolism in vitro.

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Citation (ISO format)

ANCRENAZ, Virginie et al. The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro. In: British journal of pharmacology, 2012, vol. 166, n° 8, p. 2362–2370. doi: 10.1111/j.1476-5381.2012.01946.x

Article (Published version)

Identifiers

PID : unige:26343
DOI : 10.1111/j.1476-5381.2012.01946.x
PMID : 22428615

Journal ISSN0007-1188

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The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro

Clopidogrel is a prodrug bioactivated by cytochrome P450s (CYPs). More recently, paraoxonase-1 (PON1) has been proposed as a major contributor to clopidogrel metabolism. The purpose of this study was to assess the relative contribution of CYPs and PON1 to clopidogrel metabolism in vitro.

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