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Scientific article
Open access
English

Comparing Dried Blood Spots and Plasma Concentrations for Busulfan Therapeutic Drug Monitoring in Children

Published inTherapeutic Drug Monitoring, vol. 42, no. 1, p. 111-117
Publication date2020
Abstract

Busulfan (Bu) is one of the conditioning regimen components for pediatric hematopoietic stem cell transplantation. Bu therapeutic drug monitoring (TDM) is essential for a successful treatment outcome and toxicity evasion. Dried blood spot (DBS) sampling is a rapid and simple method for Bu TDM, compared with conventional plasma sampling. This study evaluated the feasibility of using the DBS method for Bu TDM. The hematocrit (Hct) and conditioning day were also examined for their impact on the DBS method's performance.

Keywords
  • TDM
  • Dried blood spot
  • Busulfan
  • Children
  • Pharmacokinetics
Citation (ISO format)
DILO, Ana et al. Comparing Dried Blood Spots and Plasma Concentrations for Busulfan Therapeutic Drug Monitoring in Children. In: Therapeutic Drug Monitoring, 2020, vol. 42, n° 1, p. 111–117. doi: 10.1097/FTD.0000000000000673
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Article (Published version)
Identifiers
ISSN of the journal0163-4356
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108downloads

Technical informations

Creation10/28/2020 11:50:00 AM
First validation10/28/2020 11:50:00 AM
Update time03/15/2023 10:58:15 PM
Status update03/15/2023 10:58:14 PM
Last indexation02/12/2024 1:20:16 PM
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