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A simplified method for busulfan monitoring using dried blood spot in combination with liquid chromatography/tandem mass spectrometry |
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Published in | RCM. Rapid communications in mass spectrometry. 2012, vol. 26, no. 12, p. 1437-46 | |
Abstract | Busulfan (Bu) is an important component of the myeloablative conditioning regimen prior to hematopoietic stem cell transplantation (HSCT) especially in children. Intravenously administered Bu exhibits a therapeutic window phenomenon requiring therapeutic drug monitoring. Analytical methods developed for Bu routine monitoring were aimed at using low volumes of biological fluids and development of simple procedures to facilitate the dosage adjustment. In this report, we describe a simple, rapid method for Bu measurement using dried blood spots (DBS) from only 5 μL of whole blood. | |
Keywords | Busulfan/blood/pharmacokinetics — Calibration — Child — Chromatography, High Pressure Liquid/methods — Dried Blood Spot Testing/methods — Drug Stability — Humans — Linear Models — Reproducibility of Results — Spectrometry, Mass, Electrospray Ionization — Tandem Mass Spectrometry/methods | |
Identifiers | DOI: 10.1002/rcm.6241 PMID: 22592987 | |
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Research groups | Groupe Desmeules Jules (pharmacologie/toxicologie) (567) Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889) Oncologie et hématologie pédiatrique (907) Pharmaco-omiques et médecine de précision (1003) | |
Citation (ISO format) | ANSARI DJABERI, Marc Georges et al. A simplified method for busulfan monitoring using dried blood spot in combination with liquid chromatography/tandem mass spectrometry. In: RCM. Rapid communications in mass spectrometry, 2012, vol. 26, n° 12, p. 1437-46. doi: 10.1002/rcm.6241 https://archive-ouverte.unige.ch/unige:26868 |