UNIGE document Scientific Article
previous document  unige:26868  next document
add to browser collection
Title

A simplified method for busulfan monitoring using dried blood spot in combination with liquid chromatography/tandem mass spectrometry

Authors
Théorêt, Yves
show hidden authors show all authors [1 - 10]
Published in Rapid Communications in Mass Spectrometry. 2012, vol. 26, no. 12, p. 1437-46
Abstract Busulfan (Bu) is an important component of the myeloablative conditioning regimen prior to hematopoietic stem cell transplantation (HSCT) especially in children. Intravenously administered Bu exhibits a therapeutic window phenomenon requiring therapeutic drug monitoring. Analytical methods developed for Bu routine monitoring were aimed at using low volumes of biological fluids and development of simple procedures to facilitate the dosage adjustment. In this report, we describe a simple, rapid method for Bu measurement using dried blood spots (DBS) from only 5 μL of whole blood.
Keywords Busulfan/blood/pharmacokineticsCalibrationChildChromatography, High Pressure Liquid/methodsDried Blood Spot Testing/methodsDrug StabilityHumansLinear ModelsReproducibility of ResultsSpectrometry, Mass, Electrospray IonizationTandem Mass Spectrometry/methods
Identifiers
PMID: 22592987
Full text
Article (Published version) (768 Kb) - public document Free access
Structures
Research groups Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889)
Plateforme d'oncologie et d'hématologie pédiatrique (907)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Citation
(ISO format)
ANSARI DJABERI, Marc Georges et al. A simplified method for busulfan monitoring using dried blood spot in combination with liquid chromatography/tandem mass spectrometry. In: Rapid Communications in Mass Spectrometry, 2012, vol. 26, n° 12, p. 1437-46. https://archive-ouverte.unige.ch/unige:26868

315 hits

345 downloads

Update

Deposited on : 2013-03-19

Export document
Format :
Citation style :