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Detection of busulfan adducts on proteins |
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Published in | RCM. Rapid communications in mass spectrometry. 2016, vol. 30, no. 23, p. 2517-2528 | |
Abstract | Busulfan is a bifunctional alkyl sulfonate antineoplastic drug. This alkylating agent was described as forming covalent adducts on proteins. However, only limited data are available regarding the interaction of busulfan with proteins. Mass spectrometry and bioinformatics were used to identify busulfan adducts on human serum albumin and hemoglobin. | |
Identifiers | DOI: 10.1002/rcm.7730 PMID: 27599297 | |
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Research groups | Swiss Institute of Bioinformatique Chimie et protéomique clinique (270) Groupe Desmeules Jules (pharmacologie/toxicologie) (567) Oncologie et hématologie pédiatrique (907) Pharmaco-omiques et médecine de précision (1003) | |
Citation (ISO format) | ACOSTA MARTIN, Adelina Elena et al. Detection of busulfan adducts on proteins. In: RCM. Rapid communications in mass spectrometry, 2016, vol. 30, n° 23, p. 2517-2528. doi: 10.1002/rcm.7730 https://archive-ouverte.unige.ch/unige:88690 |