Detection of busulfan adducts on proteins

Acosta Martin, Adelina Elena; Antinori Malaspina, Paola; Uppugunduri Satyanarayana, Chakradhara Rao; Daali, Youssef; Ansari Djaberi, Marc Georges; Scherl, Alexander; Muller, Markus Johann; Lescuyer, Pierre

doi:10.1002/rcm.7730

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Title		Detection of busulfan adducts on proteins
Authors		Acosta Martin, Adelina Elena Antinori Malaspina, Paola Uppugunduri Satyanarayana, Chakradhara Rao Daali, Youssef Ansari Djaberi, Marc Georges Scherl, Alexander Muller, Markus Johann Lescuyer, Pierre
Published in		Rapid Communications in Mass Spectrometry. 2016, vol. 30, no. 23, p. 2517-2528
Abstract		Busulfan is a bifunctional alkyl sulfonate antineoplastic drug. This alkylating agent was described as forming covalent adducts on proteins. However, only limited data are available regarding the interaction of busulfan with proteins. Mass spectrometry and bioinformatics were used to identify busulfan adducts on human serum albumin and hemoglobin.
Identifiers		DOI: 10.1002/rcm.7730 PMID: 27599297
Full text		Article (Accepted version) (1.8 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté des sciences / Section des sciences pharmaceutiques Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups		Pharmaco-omiques et médecine de précision (1003) Swiss Institute of Bioinformatique Chimie et protéomique clinique (270) Groupe Desmeules Jules (pharmacologie/toxicologie) (567) Plateforme d'oncologie et d'hématologie pédiatrique (907)
Citation (ISO format)		ACOSTA MARTIN, Adelina Elena et al. Detection of busulfan adducts on proteins. In: Rapid Communications in Mass Spectrometry, 2016, vol. 30, n° 23, p. 2517-2528. doi: 10.1002/rcm.7730 https://archive-ouverte.unige.ch/unige:88690