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Title

Detection of busulfan adducts on proteins
Authors
Acosta Martin, Adelina Elena
Antinori Malaspina, Paola
Uppugunduri Satyanarayana, Chakradhara Rao
Daali, Youssef
Ansari Djaberi, Marc Georges
Scherl, Alexander
Muller, Markus Johann
Lescuyer, Pierre
Published in Rapid Communications in Mass Spectrometry. 2016, vol. 30, no. 23, p. 2517-2528
Abstract Busulfan is a bifunctional alkyl sulfonate antineoplastic drug. This alkylating agent was described as forming covalent adducts on proteins. However, only limited data are available regarding the interaction of busulfan with proteins. Mass spectrometry and bioinformatics were used to identify busulfan adducts on human serum albumin and hemoglobin.
Identifiers
PMID: 27599297
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Article (Author postprint) (1.8 MB) - public document Free access
Structures
Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Faculté des sciences / Section des sciences pharmaceutiques
Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Faculté de médecine / Section de médecine clinique / Département de pédiatrie
Research groups Swiss Institute of Bioinformatique
Chimie et protéomique clinique (270)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Plateforme d'oncologie et d'hématologie pédiatrique (907)
Citation
(ISO format) 		ACOSTA MARTIN, Adelina Elena et al. Detection of busulfan adducts on proteins. In: Rapid Communications in Mass Spectrometry, 2016, vol. 30, n° 23, p. 2517-2528. https://archive-ouverte.unige.ch/unige:88690

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Deposited on : 2016-11-04

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