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Detection of busulfan adducts on proteins

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Published in Rapid Communications in Mass Spectrometry. 2016, vol. 30, no. 23, p. 2517-2528
Abstract Busulfan is a bifunctional alkyl sulfonate antineoplastic drug. This alkylating agent was described as forming covalent adducts on proteins. However, only limited data are available regarding the interaction of busulfan with proteins. Mass spectrometry and bioinformatics were used to identify busulfan adducts on human serum albumin and hemoglobin.
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PMID: 27599297
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Research groups Pharmaco-omiques et médecine de précision (1003)
Swiss Institute of Bioinformatique
Chimie et protéomique clinique (270)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Plateforme d'oncologie et d'hématologie pédiatrique (907)
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ACOSTA MARTIN, Adelina Elena et al. Detection of busulfan adducts on proteins. In: Rapid Communications in Mass Spectrometry, 2016, vol. 30, n° 23, p. 2517-2528. doi: 10.1002/rcm.7730 https://archive-ouverte.unige.ch/unige:88690

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Deposited on : 2016-11-04

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