Detection of busulfan adducts on proteins

Acosta Martin, Adelina Elena; Antinori Malaspina, Paola; Uppugunduri Satyanarayana, Chakradhara Rao; Daali, Youssef; Ansari Djaberi, Marc Georges; Scherl, Alexander; Muller, Markus Johann; Lescuyer, Pierre

doi:10.1002/rcm.7730

Scientific article

English

Detection of busulfan adducts on proteins

ContributorsAcosta Martin, Adelina Elena; Antinori Malaspina, Paola; Uppugunduri Satyanarayana, Chakradhara Rao

; Daali, Youssef; Ansari Djaberi, Marc Georges; Scherl, Alexander; Muller, Markus Johann; Lescuyer, Pierre

Published inRCM. Rapid communications in mass spectrometry, vol. 30, no. 23, p. 2517-2528

Publication date2016

Abstract

Busulfan is a bifunctional alkyl sulfonate antineoplastic drug. This alkylating agent was described as forming covalent adducts on proteins. However, only limited data are available regarding the interaction of busulfan with proteins. Mass spectrometry and bioinformatics were used to identify busulfan adducts on human serum albumin and hemoglobin.

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Citation (ISO format)

ACOSTA MARTIN, Adelina Elena et al. Detection of busulfan adducts on proteins. In: RCM. Rapid communications in mass spectrometry, 2016, vol. 30, n° 23, p. 2517–2528. doi: 10.1002/rcm.7730

Article (Accepted version)

Identifiers

PID : unige:88690
DOI : 10.1002/rcm.7730
PMID : 27599297

Journal ISSN0951-4198

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Detection of busulfan adducts on proteins

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