UNIGE document Scientific Article - Review
previous document  unige:34825  next document
add to browser collection
Title

Antiplatelet Therapy: Targeting the TxA2 Pathway

Authors
Published in Journal of Cardiovascular Translational Research. 2014, vol. 7, no. 1, p. 29-38
Abstract The thromboxane (Tx) A2 pathway is a major contributor to the amplification of the initial platelet activation process. TxA2 mediates its effect through the thromboxane prostanoid (TP) receptor that is expressed not only in platelets, but also in endothelial cells, macrophages, and monocytes, and thus contributes to the development of atherosclerotic lesions. The TxA2 pathway is therefore a major target in the treatment of cardiovascular disease. Aspirin-the most widely used antiplatelet drug-is very effective at inhibiting platelet-derived TxA2 synthesis. However, aspirin's effects can be overcome by several other soluble agonists such as isoprostanes, which are aspirin-insensitive ligands of the TP receptor that are preferentially produced in diabetes mellitus. Other drugs, with either inhibitory effects on Tx synthase or antagonist effects on TP, have been developed with the hope of providing a better, more complete inhibition of the TxA2 pathway.
Identifiers
PMID: 24353037
Full text
Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Geneva Platelet Group (13)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Citation
(ISO format)
FONTANA, Pierre et al. Antiplatelet Therapy: Targeting the TxA2 Pathway. In: Journal of Cardiovascular Translational Research, 2014, vol. 7, n° 1, p. 29-38. https://archive-ouverte.unige.ch/unige:34825

172 hits

2 downloads

Update

Deposited on : 2014-03-18

Export document
Format :
Citation style :