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Scientific article
English

Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis

Published inJournal of thrombosis and haemostasis, vol. 10, no. 7, p. 1242-1251
Publication date2012
Abstract

A poor biological response to clopidogrel is associated with an increased risk of major cardiovascular ischemic events (MACE). Paraoxonase 1 (PON1) enzyme activity is modulated by the PON1-Q192R variant (rs662) and was recently suggested to be strongly involved in clopidogrel bioactivation, but the influence of the PON1-Q192R variant on the risk of MACE in clopidogrel-treated patients is controversial.

Citation (ISO format)
RENY, Jean-Luc et al. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis. In: Journal of thrombosis and haemostasis, 2012, vol. 10, n° 7, p. 1242–1251. doi: 10.1111/j.1538-7836.2012.04756.x
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ISSN of the journal1538-7836
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Technical informations

Creation11/06/2012 4:26:00 PM
First validation11/06/2012 4:26:00 PM
Update time03/14/2023 8:02:34 PM
Status update03/14/2023 8:02:34 PM
Last indexation01/16/2024 1:11:22 AM
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