Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis

Reny, Jean-Luc; Combescure, Christophe; Daali, Youssef; Fontana, Pierre

doi:10.1111/j.1538-7836.2012.04756.x

Scientific article

English

Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis

ContributorsReny, Jean-Luc

; Combescure, Christophe

; Daali, Youssef; Fontana, Pierre

Published inJournal of thrombosis and haemostasis, vol. 10, no. 7, p. 1242-1251

Publication date2012

Abstract

A poor biological response to clopidogrel is associated with an increased risk of major cardiovascular ischemic events (MACE). Paraoxonase 1 (PON1) enzyme activity is modulated by the PON1-Q192R variant (rs662) and was recently suggested to be strongly involved in clopidogrel bioactivation, but the influence of the PON1-Q192R variant on the risk of MACE in clopidogrel-treated patients is controversial.

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Citation (ISO format)

RENY, Jean-Luc et al. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis. In: Journal of thrombosis and haemostasis, 2012, vol. 10, n° 7, p. 1242–1251. doi: 10.1111/j.1538-7836.2012.04756.x

Article (Published version)

Identifiers

PID : unige:26332
DOI : 10.1111/j.1538-7836.2012.04756.x
PMID : 22520065

Journal ISSN1538-7836

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Creation06/11/2012 16:26:00

First validation06/11/2012 16:26:00

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Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis

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