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Title

Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis

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Published in Journal of Thrombosis and Haemostasis. 2012, vol. 10, no. 7, p. 1242-51
Abstract A poor biological response to clopidogrel is associated with an increased risk of major cardiovascular ischemic events (MACE). Paraoxonase 1 (PON1) enzyme activity is modulated by the PON1-Q192R variant (rs662) and was recently suggested to be strongly involved in clopidogrel bioactivation, but the influence of the PON1-Q192R variant on the risk of MACE in clopidogrel-treated patients is controversial.
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PMID: 22520065
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Article (Published version) (284 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Geneva Platelet Group (13)
Epidémiologie clinique (115)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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(ISO format)
RENY, Jean-Luc et al. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis. In: Journal of Thrombosis and Haemostasis, 2012, vol. 10, n° 7, p. 1242-51. https://archive-ouverte.unige.ch/unige:26332

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Deposited on : 2013-02-11

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