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Title

Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis
Authors
Reny, Jean-Luc
Combescure, Christophe
Daali, Youssef
Fontana, Pierre
Published in Journal of Thrombosis and Haemostasis. 2012, vol. 10, no. 7, p. 1242-51
Abstract A poor biological response to clopidogrel is associated with an increased risk of major cardiovascular ischemic events (MACE). Paraoxonase 1 (PON1) enzyme activity is modulated by the PON1-Q192R variant (rs662) and was recently suggested to be strongly involved in clopidogrel bioactivation, but the influence of the PON1-Q192R variant on the risk of MACE in clopidogrel-treated patients is controversial.
Identifiers
PMID: 22520065
Full text
Article (Published version) (284 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie et soins intensifs chirurgicaux
Research groups Geneva Platelet Group (13)
Epidémiologie clinique (115)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Citation
(ISO format) 		RENY, Jean-Luc et al. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis. In: Journal of Thrombosis and Haemostasis, 2012, vol. 10, n° 7, p. 1242-51. https://archive-ouverte.unige.ch/unige:26332

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Deposited on : 2013-02-11

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