Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis

Reny, Jean-Luc; Combescure, Christophe; Daali, Youssef; Fontana, Pierre

doi:10.1111/j.1538-7836.2012.04756.x

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Title		Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis
Authors		Reny, Jean-Luc Combescure, Christophe Daali, Youssef Fontana, Pierre
Published in		Journal of Thrombosis and Haemostasis. 2012, vol. 10, no. 7, p. 1242-51
Abstract		A poor biological response to clopidogrel is associated with an increased risk of major cardiovascular ischemic events (MACE). Paraoxonase 1 (PON1) enzyme activity is modulated by the PON1-Q192R variant (rs662) and was recently suggested to be strongly involved in clopidogrel bioactivation, but the influence of the PON1-Q192R variant on the risk of MACE in clopidogrel-treated patients is controversial.
Identifiers		DOI: 10.1111/j.1538-7836.2012.04756.x PMID: 22520065
Full text		Article (Published version) (284 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences
Research groups		Epidémiologie clinique (115) Geneva Platelet Group (13) Groupe Desmeules Jules (pharmacologie/toxicologie) (567) Pharmaco-omiques et médecine de précision (1003)
Citation (ISO format)		RENY, Jean-Luc et al. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis. In: Journal of Thrombosis and Haemostasis, 2012, vol. 10, n° 7, p. 1242-51. doi: 10.1111/j.1538-7836.2012.04756.x https://archive-ouverte.unige.ch/unige:26332