Picard, Didier

Title	Published in	Year	Views	Downloads
Phosphorylation of the Hsp90 Co-Chaperone Hop Changes its Conformational Dynamics and Biological Function	Journal of Molecular Biology	2023	152	1
Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer	Cellular and molecular life sciences	2023	126	345
CRISPR-Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells	Science advances	2023	94	467
Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress	eLife	2023	103	234
Cytosolic Hsp90 Isoform-Specific Functions and Clinical Significance	Biomolecules	2022	173	856
The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors	Biomolecules	2022	113	395
Hyperactivation of MAPK Induces Tamoxifen Resistance in SPRED2-Deficient ERα-Positive Breast Cancer	Cancers	2022	217	416
Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis	Nature communications	2022	191	107
Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life	Nature communications	2022	325	508
The Hsp70–Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration	Cellular and molecular life sciences	2021	8	41
H90-10 single-chain antibody recognizes Hsp90beta by immunoprecipitation and Western blotting	Antibody reports	2021	193	140
The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation	Nature Communications	2020	310	253
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis	BMC Biology	2020	359	186
Implementation of liquid chromatography–high resolution mass spectrometry methods for untargeted metabolomic analyses of biological samples: A tutorial	Analytica Chimica Acta	2020	428	1
Genetic ablation of MiR-22 fosters diet-induced obesity and NAFLD development	Journal of Personalized Medicine	2020	360	217
Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling	Nature Communications	2019	533	288
AI179 single-chain antibody recognizes the Myc tag by Western blotting	Antibody Reports	2019	337	318
The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity	PloS one	2019	510	358
A scoring approach for multi-platform acquisition in metabolomics	Journal of Chromatography. A	2019	488	1
AF291 and AE391 single-chain antibodies recognize the HA tag by Western blotting	Antibody Reports	2019	538	250
ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1	Life Science Alliance	2018	452	194
Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development	Cell Stress and Chaperones	2018	509	583
Luminescence resonance energy transfer between genetically encoded donor and acceptor for protein-protein interaction studies in the molecular chaperone HSP70/HSP90 complexes	Scientific Reports	2018	437	223
A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells	Oncotarget	2017	540	263
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease	Brain	2017	512	0
Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol	ACS Medicinal Chemistry Letters	2017	512	0
H2B monoubiquitination: t'ub or not t'ub for inducible enhancers	Transcription	2017	523	317
Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model	Oncotarget	2017	525	264
Dendrogenin A drives LXR to trigger lethal autophagy in cancers	Nature Communications	2017	585	444
Secreted dual reporter assay with Gaussia luciferase and the red fluorescent protein mCherry	PLOS ONE	2017	556	451
Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23	PloS one	2017	460	247
A remodeled Hsp90 molecular chaperone ensemble with the novel co-chaperone Aarsd1 is required for muscle differentiation	Molecular and cellular biology	2016	521	339
Monoubiquitination of Histone H2B Blocks Eviction of Histone Variant H2A.Z from Inducible Enhancers	Molecular cell	2016	600	490
GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response	Scientific reports	2016	601	391
LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP	Nucleic acids research	2016	588	447
Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis	Hsp90 in Cancer: Beyond the Usual Suspects	2016	619	1
Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles	Journal of medicinal chemistry	2016	505	0
Minireview: Tipping the balance: ligand-independent activation of steroid receptors	Molecular endocrinology	2015	872	1
Overview of molecular chaperones in health and disease	Inhibitors of Molecular Chaperones as Therapeutic Agents	2014	581	1
Differences in Conformational Dynamics between Plasmodium falciparum and Human Hsp90 Orthologues Enable the Structure-Based Discovery of Pathogen-Selective Inhibitors	Journal of medicinal chemistry	2014	724	791
A global view of the proteome perturbations by Hsp90 inhibitors	The Molecular Chaperones Interaction Networks in Protein Folding and Degradation	2014	719	0
Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells	Trends in cell biology	2014	698	45
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis	Proceedings of the National Academy of Sciences of the United States of America	2013	1,009	691
Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy	PloS one	2013	708	358
The Human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter	The Journal of experimental medicine	2013	805	681
Preface to Hsp90	Biochimica et biophysica acta. Molecular cell research	2012	614	399
An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine	PloS one	2011	618	410
Influenza Virus Infection Induces the Nuclear Relocalization of the Hsp90 Co-Chaperone p23 and Inhibits the Glucocorticoid Receptor Response	PloS one	2011	788	416
The Cholesterol Metabolite 25-Hydroxycholesterol Activates Estrogen Receptor α-Mediated Signaling in Cancer Cells and in Cardiomyocytes	PloS one	2011	570	637
Detection of changes in gene regulatory patterns, elicited by perturbations of the Hsp90 molecular chaperone complex, by visualizing multiple experiments with an animation	BioData mining	2011	698	1,177
CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP	Genes & development	2010	630	0
Multidirectional interplay between nuclear receptors and microRNAs	Current opinion in pharmacology	2010	600	0
Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility	Biochimica et biophysica acta	2010	543	0
The unfolding stories of GPR30, a new membrane-bound estrogen receptor	Journal of Endocrinology	2010	1,024	0
The molecular chaperone Hsp90alpha is required for meiotic progression of spermatocytes beyond pachytene in the mouse	PloS one	2010	772	503
miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA	Molecular and cellular biology	2009	662	0
The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities	Molecular and biochemical parasitology	2009	808	0
Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF	EMBO journal	2009	1,386	1,038
Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells	Endocrinology	2008	1,123	0
Genomics of signaling crosstalk of estrogen receptor alpha in breast cancer cells	PloS one	2008	578	319
A stress protein interface of innate immunity	EMBO reports	2008	630	245
The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation	Immunity	2008	580	0
p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity	Molecular and cellular biology	2008	740	0
The glucocorticoid responses are shaped by molecular chaperones	Molecular and cellular endocrinology	2007	570	0
Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome	Digestive diseases and sciences	2007	630	564
Chaperoning steroid hormone action	Trends in endocrinology and metabolism	2006	656	0
Fungi and animals may share a common ancestor to nuclear receptors	Proceedings of the National Academy of Sciences of the United States of America	2006	570	0
Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90	Experimental cell research	2006	565	1
The cell-specific activity of the estrogen receptor alpha may be fine-tuned by phosphorylation-induced structural gymnastics	Nuclear receptor signaling	2006	623	260
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells	Molecular endocrinology	2006	901	0
2-color photobleaching experiments reveal distinct intracellular dynamics of two components of the Hsp90 complex	Experimental cell research	2006	629	2
The Hsp90 cochaperone p23 is essential for perinatal survival	Molecular and cellular biology	2006	659	1
[Retracted] 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30	Molecular pharmacology	2006	1,114	0
Bioluminescent yeast assays for detecting estrogenic and androgenic activity in different matrices	Chemosphere	2005	623	1
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes	Human molecular genetics	2005	664	0
siRNA production by in vitro transcription	Gene silencing by RNA interference : technology and application	2005	632	1
A yeast-based assay reveals a functional defect of the Q488H polymorphism in human Hsp90alpha	Biochemical and biophysical research communications	2005	579	2
SPBP is a phosphoserine-specific repressor of estrogen receptor alpha	Molecular and cellular biology	2005	578	0
The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells	The Journal of biological chemistry	2004	831	0
A web application to manage a database for liquid nitrogen tanks	Immunology and cell biology	2004	601	1
A recombinant yeast strain as a short term bioassay to assess estrogen-like activity of xenobiotics	Annali di igiene medicina preventiva e di comunità	2004	468	0
The protein kinase PKR: a molecular clock that sequentially activates survival and death programs	EMBO journal	2004	608	0
TROD: T7 RNAi oligo designer	Nucleic acids research	2004	687	427
Oestrogen receptor beta is required for androgen-stimulated proliferation of LNCaP prostate cancer cells	Journal of molecular endocrinology	2004	629	0
Hsp90 invades the outside	Nature cell biology	2004	531	0
The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo	EMBO journal	2003	620	0
Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling	Pure and applied chemistry	2003	624	620
Cdc37 goes beyond Hsp90 and kinases	Cell stress & chaperones	2003	630	3
Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation	Molecular and cellular biology	2002	553	0
Aromatase overexpression enhances the stimulatory effects of adrenal androgens on MCF7 breast cancer cells	Molecular and cellular endocrinology	2002	654	0
Heat-shock protein 90, a chaperone for folding and regulation	Cellular and molecular life sciences	2002	674	2
The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically	Biological chemistry	2002	660	0
RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase	Nucleic acids research	2002	603	370
The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR	EMBO journal	2001	649	0
Hsp104 interacts with Hsp90 cochaperones in respiring yeast	Molecular and cellular biology	2001	646	0
Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells	Molecular pharmacology	2001	560	0
The direct proliferative stimulus of dehydroepiandrosterone on MCF7 breast cancer cells is potentiated by overexpression of aromatase	Molecular and cellular endocrinology	2001	677	0
Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects	The Journal of biological chemistry	2000	637	0
Posttranslational regulation of proteins by fusions to steroid-binding domains	Methods in Enzymology, vol. 327 : Applications of chimeric genes and hybrid proteins, part B. Cell biology and physiology	2000	563	0
The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest	FEBS letters	2000	726	0
Ligand-independent activation of steroid receptors: new roles for old players	Trends in endocrinology and metabolism	1999	664	0
Alpha-complemented beta-galactosidase. An in vivo model substrate for the molecular chaperone heat-shock protein 90 in yeast	European journal of biochemistry	1999	876	3
A yeast-based bioassay for the determination of functional and non-functional estrogen receptors	Nucleic acids research	1999	560	255
A non-radioactive method for inexpensive quantitative RT-PCR	Biological chemistry	1999	662	0
Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]	Molecular and cellular biology	1999	511	0
Regulation of heterologous proteins by fusion to a hormone binding domain	Nuclear receptors : a practical approach	1999	675	0
The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system	Biological chemistry	1999	605	0
Two compounds commonly used for phospholipase C inhibition activate the nuclear estrogen receptors	Biochemical and biophysical research communications	1999	579	1
Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor alpha	Cancer research	1999	535	1
Bioactive steroids as contaminants of the common carbon source galactose	FEMS microbiology letters	1998	588	0
Steroid-binding domains for regulating the functions of heterologous proteins in cis	Trends in cell biology	1993	561	0