Picard, Didier

Title	Published in	Year	Views	Downloads
Phosphorylation of the Hsp90 Co-Chaperone Hop Changes its Conformational Dynamics and Biological Function	Journal of Molecular Biology	2023	156	1
Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer	Cellular and molecular life sciences	2023	130	393
CRISPR-Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells	Science advances	2023	99	554
Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress	eLife	2023	108	246
Cytosolic Hsp90 Isoform-Specific Functions and Clinical Significance	Biomolecules	2022	177	964
The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors	Biomolecules	2022	118	454
Hyperactivation of MAPK Induces Tamoxifen Resistance in SPRED2-Deficient ERα-Positive Breast Cancer	Cancers	2022	221	437
Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis	Nature communications	2022	195	118
Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life	Nature communications	2022	330	547
The Hsp70–Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration	Cellular and molecular life sciences	2021	13	88
H90-10 single-chain antibody recognizes Hsp90beta by immunoprecipitation and Western blotting	Antibody reports	2021	197	152
The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation	Nature Communications	2020	316	260
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis	BMC Biology	2020	366	191
Implementation of liquid chromatography–high resolution mass spectrometry methods for untargeted metabolomic analyses of biological samples: A tutorial	Analytica Chimica Acta	2020	435	1
Genetic ablation of MiR-22 fosters diet-induced obesity and NAFLD development	Journal of Personalized Medicine	2020	365	219
Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling	Nature Communications	2019	538	295
AI179 single-chain antibody recognizes the Myc tag by Western blotting	Antibody Reports	2019	342	329
The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity	PloS one	2019	515	364
A scoring approach for multi-platform acquisition in metabolomics	Journal of Chromatography. A	2019	495	1
AF291 and AE391 single-chain antibodies recognize the HA tag by Western blotting	Antibody Reports	2019	544	258
ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1	Life Science Alliance	2018	458	210
Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development	Cell Stress and Chaperones	2018	514	613
Luminescence resonance energy transfer between genetically encoded donor and acceptor for protein-protein interaction studies in the molecular chaperone HSP70/HSP90 complexes	Scientific Reports	2018	442	227
A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells	Oncotarget	2017	548	275
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease	Brain	2017	518	0
Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol	ACS Medicinal Chemistry Letters	2017	517	0
H2B monoubiquitination: t'ub or not t'ub for inducible enhancers	Transcription	2017	531	329
Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model	Oncotarget	2017	532	269
Dendrogenin A drives LXR to trigger lethal autophagy in cancers	Nature Communications	2017	591	465
Secreted dual reporter assay with Gaussia luciferase and the red fluorescent protein mCherry	PLOS ONE	2017	562	489
Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23	PloS one	2017	467	268
A remodeled Hsp90 molecular chaperone ensemble with the novel co-chaperone Aarsd1 is required for muscle differentiation	Molecular and cellular biology	2016	528	356
Monoubiquitination of Histone H2B Blocks Eviction of Histone Variant H2A.Z from Inducible Enhancers	Molecular cell	2016	606	508
GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response	Scientific reports	2016	608	392
LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP	Nucleic acids research	2016	595	459
Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis	Hsp90 in Cancer: Beyond the Usual Suspects	2016	625	1
Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles	Journal of medicinal chemistry	2016	511	0
Minireview: Tipping the balance: ligand-independent activation of steroid receptors	Molecular endocrinology	2015	880	1
Overview of molecular chaperones in health and disease	Inhibitors of Molecular Chaperones as Therapeutic Agents	2014	588	1
Differences in Conformational Dynamics between Plasmodium falciparum and Human Hsp90 Orthologues Enable the Structure-Based Discovery of Pathogen-Selective Inhibitors	Journal of medicinal chemistry	2014	732	855
A global view of the proteome perturbations by Hsp90 inhibitors	The Molecular Chaperones Interaction Networks in Protein Folding and Degradation	2014	725	0
Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells	Trends in cell biology	2014	706	45
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis	Proceedings of the National Academy of Sciences of the United States of America	2013	1,018	719
Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy	PloS one	2013	716	372
The Human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter	The Journal of experimental medicine	2013	813	693
Preface to Hsp90	Biochimica et biophysica acta. Molecular cell research	2012	621	436
An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine	PloS one	2011	625	413
Influenza Virus Infection Induces the Nuclear Relocalization of the Hsp90 Co-Chaperone p23 and Inhibits the Glucocorticoid Receptor Response	PloS one	2011	795	446
The Cholesterol Metabolite 25-Hydroxycholesterol Activates Estrogen Receptor α-Mediated Signaling in Cancer Cells and in Cardiomyocytes	PloS one	2011	577	653
Detection of changes in gene regulatory patterns, elicited by perturbations of the Hsp90 molecular chaperone complex, by visualizing multiple experiments with an animation	BioData mining	2011	705	1,182
CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP	Genes & development	2010	636	0
Multidirectional interplay between nuclear receptors and microRNAs	Current opinion in pharmacology	2010	606	0
Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility	Biochimica et biophysica acta	2010	551	0
The unfolding stories of GPR30, a new membrane-bound estrogen receptor	Journal of Endocrinology	2010	1,030	0
The molecular chaperone Hsp90alpha is required for meiotic progression of spermatocytes beyond pachytene in the mouse	PloS one	2010	784	540
miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA	Molecular and cellular biology	2009	668	0
The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities	Molecular and biochemical parasitology	2009	814	0
Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF	EMBO journal	2009	1,393	1,043
Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells	Endocrinology	2008	1,129	0
Genomics of signaling crosstalk of estrogen receptor alpha in breast cancer cells	PloS one	2008	584	325
A stress protein interface of innate immunity	EMBO reports	2008	639	252
The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation	Immunity	2008	587	0
p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity	Molecular and cellular biology	2008	748	0
The glucocorticoid responses are shaped by molecular chaperones	Molecular and cellular endocrinology	2007	578	0
Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome	Digestive diseases and sciences	2007	637	580
Chaperoning steroid hormone action	Trends in endocrinology and metabolism	2006	662	0
Fungi and animals may share a common ancestor to nuclear receptors	Proceedings of the National Academy of Sciences of the United States of America	2006	577	0
Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90	Experimental cell research	2006	572	1
The cell-specific activity of the estrogen receptor alpha may be fine-tuned by phosphorylation-induced structural gymnastics	Nuclear receptor signaling	2006	629	269
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells	Molecular endocrinology	2006	908	0
2-color photobleaching experiments reveal distinct intracellular dynamics of two components of the Hsp90 complex	Experimental cell research	2006	636	2
The Hsp90 cochaperone p23 is essential for perinatal survival	Molecular and cellular biology	2006	668	1
[Retracted] 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30	Molecular pharmacology	2006	1,121	0
Bioluminescent yeast assays for detecting estrogenic and androgenic activity in different matrices	Chemosphere	2005	630	1
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes	Human molecular genetics	2005	671	0
siRNA production by in vitro transcription	Gene silencing by RNA interference : technology and application	2005	639	1
A yeast-based assay reveals a functional defect of the Q488H polymorphism in human Hsp90alpha	Biochemical and biophysical research communications	2005	586	2
SPBP is a phosphoserine-specific repressor of estrogen receptor alpha	Molecular and cellular biology	2005	584	0
The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells	The Journal of biological chemistry	2004	838	0
A web application to manage a database for liquid nitrogen tanks	Immunology and cell biology	2004	608	1
A recombinant yeast strain as a short term bioassay to assess estrogen-like activity of xenobiotics	Annali di igiene medicina preventiva e di comunità	2004	475	0
The protein kinase PKR: a molecular clock that sequentially activates survival and death programs	EMBO journal	2004	615	0
TROD: T7 RNAi oligo designer	Nucleic acids research	2004	693	443
Oestrogen receptor beta is required for androgen-stimulated proliferation of LNCaP prostate cancer cells	Journal of molecular endocrinology	2004	636	0
Hsp90 invades the outside	Nature cell biology	2004	538	0
The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo	EMBO journal	2003	627	0
Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling	Pure and applied chemistry	2003	631	633
Cdc37 goes beyond Hsp90 and kinases	Cell stress & chaperones	2003	636	3
Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation	Molecular and cellular biology	2002	560	0
Aromatase overexpression enhances the stimulatory effects of adrenal androgens on MCF7 breast cancer cells	Molecular and cellular endocrinology	2002	661	0
Heat-shock protein 90, a chaperone for folding and regulation	Cellular and molecular life sciences	2002	681	2
The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically	Biological chemistry	2002	666	0
RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase	Nucleic acids research	2002	609	407
The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR	EMBO journal	2001	655	0
Hsp104 interacts with Hsp90 cochaperones in respiring yeast	Molecular and cellular biology	2001	652	0
Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells	Molecular pharmacology	2001	568	0
The direct proliferative stimulus of dehydroepiandrosterone on MCF7 breast cancer cells is potentiated by overexpression of aromatase	Molecular and cellular endocrinology	2001	684	0
Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects	The Journal of biological chemistry	2000	644	0
Posttranslational regulation of proteins by fusions to steroid-binding domains	Methods in Enzymology, vol. 327 : Applications of chimeric genes and hybrid proteins, part B. Cell biology and physiology	2000	569	0
The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest	FEBS letters	2000	733	0
Ligand-independent activation of steroid receptors: new roles for old players	Trends in endocrinology and metabolism	1999	671	0
Alpha-complemented beta-galactosidase. An in vivo model substrate for the molecular chaperone heat-shock protein 90 in yeast	European journal of biochemistry	1999	882	3
A yeast-based bioassay for the determination of functional and non-functional estrogen receptors	Nucleic acids research	1999	567	266
A non-radioactive method for inexpensive quantitative RT-PCR	Biological chemistry	1999	669	0
Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]	Molecular and cellular biology	1999	518	0
Regulation of heterologous proteins by fusion to a hormone binding domain	Nuclear receptors : a practical approach	1999	681	0
The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system	Biological chemistry	1999	611	0
Two compounds commonly used for phospholipase C inhibition activate the nuclear estrogen receptors	Biochemical and biophysical research communications	1999	585	1
Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor alpha	Cancer research	1999	541	1
Bioactive steroids as contaminants of the common carbon source galactose	FEMS microbiology letters	1998	594	0
Steroid-binding domains for regulating the functions of heterologous proteins in cis	Trends in cell biology	1993	568	0