Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling

Picard, Didier

doi:10.1351/pac200375111743

Scientific article

English

Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling

Contributors

Picard, Didier

Published in

Pure and applied chemistry, vol. 75, no. 11-12, p. 1743-1756

Publication date

2003

Abstract

Signaling pathways can be linear, but more complex patterns are common. Growth factors and many other extracellular signals cannot directly enter cells and transduce their information via membrane-bound receptors. In contrast, steroid receptors are members of the nuclear receptor superfamily and await their cognate hormones inside the cells. These two types of signaling pathways are extensively intertwined and cross-talk at many different levels. A wide range of extra- and intracellular signals, including a variety of growth factors, can activate the transcriptional activity of steroid receptors in the absence of their cognate hormones. Conversely, steroid receptors lead a double life. By coupling to signaling molecules that mediate signal transduction of extracellular factors, they can elicit very rapid nongenomic responses. The signaling pathways of steroid-independent activation of steroid receptors, on the one hand, and of nongenomic signaling by steroid receptors, on the other, display a remarkable reciprocal relationship suggesting that these two modes of signaling cross-talk may be two faces of the same coin.

Note

Report from a SCOPE/IUPAC project: Implication of Endocrine Active Substances for Human and Wildlife

UNIGE affiliation entities

Faculté des sciences / Section de biologie / Département de biologie cellulaire

Citation (ISO format)

PICARD, Didier. Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling. In: Pure and applied chemistry, 2003, vol. 75, n° 11-12, p. 1743–1756. doi: 10.1351/pac200375111743

Article (Published version)

Identifiers

PID : unige:4614
DOI : 10.1351/pac200375111743

Additional URL for this publication

http://www.iupac.org/publications/pac/75/11/1743/

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04/12/2009 15:15:00

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04/12/2009 15:15:00

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14/03/2023 15:19:27

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29/10/2024 12:46:54

Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling

Contributors

Published in

Publication date

Abstract

Note

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Technical informations

Creation

First validation

Update

Status update

Last indexation