Minireview: Tipping the balance: ligand-independent activation of steroid receptors

Bennesch, Marcela; Picard, Didier

doi:10.1210/me.2014-1315

Scientific article

English

Minireview: Tipping the balance: ligand-independent activation of steroid receptors

Contributors

Bennesch, Marcela; Picard, Didier

Published in

Molecular endocrinology, vol. 29, no. 3, p. 349-363

Publication date

2015

Abstract

Steroid receptors are prototypical ligand-dependent transcription factors and a textbook example for allosteric regulation. According to this canonical model, binding of cognate steroid is an absolute requirement for transcriptional activation. Remarkably, the simple one ligand-one receptor model could not be farther from the truth. Steroid receptors, notably the sex steroid receptors, can receive multiple inputs. Activation of steroid receptors by other signals, working through their own signaling pathways, in the absence of the cognate steroids, represents the most extreme form of signaling cross talk. Compared with cognate steroids, ligand-independent activation pathways produce similar but not identical outputs. Here we review the phenomena and discuss what is known about the underlying molecular mechanisms and the biological significance. We hypothesize that steroid receptors may have evolved to be trigger happy. In addition to their cognate steroids, many posttranslational modifications and interactors, modulated by other signals, may be able to tip the balance.

UNIGE affiliation entities

Faculté des sciences / Section de biologie / Département de biologie cellulaire

UNIGE research groups

Groupe Picard

Citation (ISO format)

BENNESCH, Marcela, PICARD, Didier. Minireview: Tipping the balance: ligand-independent activation of steroid receptors. In: Molecular endocrinology, 2015, vol. 29, n° 3, p. 349–363. doi: 10.1210/me.2014-1315

Article (Published version)

Identifiers

PID : unige:74465
DOI : 10.1210/me.2014-1315
PMID : 25625619

Journal ISSN

0888-8809

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Creation

04/08/2015 12:19:00

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04/08/2015 12:19:00

Update

14/03/2023 23:31:09

Status update

14/03/2023 23:31:09

Last indexation

31/10/2024 00:58:39

Minireview: Tipping the balance: ligand-independent activation of steroid receptors

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation