UNIGE document Scientific Article
previous document  unige:74465  next document
add to browser collection
Title

Minireview: Tipping the balance: ligand-independent activation of steroid receptors

Authors
Published in Molecular Endocrinology. 2015, vol. 29, no. 3, p. 349-363
Abstract Steroid receptors are prototypical ligand-dependent transcription factors and a textbook example for allosteric regulation. According to this canonical model, binding of cognate steroid is an absolute requirement for transcriptional activation. Remarkably, the simple one ligand-one receptor model could not be farther from the truth. Steroid receptors, notably the sex steroid receptors, can receive multiple inputs. Activation of steroid receptors by other signals, working through their own signaling pathways, in the absence of the cognate steroids, represents the most extreme form of signaling cross talk. Compared with cognate steroids, ligand-independent activation pathways produce similar but not identical outputs. Here we review the phenomena and discuss what is known about the underlying molecular mechanisms and the biological significance. We hypothesize that steroid receptors may have evolved to be trigger happy. In addition to their cognate steroids, many posttranslational modifications and interactors, modulated by other signals, may be able to tip the balance.
Identifiers
PMID: 25625619
Full text
Article (Published version) (226 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Groupe Picard
Citation
(ISO format)
BENNESCH, Marcela, PICARD, Didier. Minireview: Tipping the balance: ligand-independent activation of steroid receptors. In: Molecular Endocrinology, 2015, vol. 29, n° 3, p. 349-363. https://archive-ouverte.unige.ch/unige:74465

145 hits

0 download

Update

Deposited on : 2015-08-04

Export document
Format :
Citation style :