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Titles listThe protein kinase PKR: a molecular clock that sequentially activates survival and death programs
Titles listThe protein kinase PKR: a molecular clock that sequentially activates survival and death programs
Scientific Article
unige:4659 
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The protein kinase PKR: a molecular clock that sequentially activates survival and death programs |
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| Authors | ||
| Published in | EMBO Journal. 2004, vol. 23, no. 3, p. 564-71 | |
| Abstract | Cell death and survival play a key role in the immune system as well as during development. The control mechanisms that balance cell survival against cell death are not well understood. Here we report a novel strategy used by a single protein to regulate chronologically cell survival and death. The interferon-induced protein kinase PKR acts as a molecular clock by using catalysis-dependent and -independent activities to temporally induce cell survival prior to cell death. We show that the proapoptotic protein PKR surprisingly activates a survival pathway, which is mediated by NF-kappaB to delay apoptosis. Cell death is then induced by PKR through the phosphorylation of eIF-2alpha. This unique temporal control might serve as a paradigm for other kinases whose catalytic activity is not required for all of their functions. | |
| Keywords | Animals — Apoptosis/physiology — Cell Survival/physiology — Eukaryotic Initiation Factor-2/metabolism — Mice — NF-kappa B/metabolism — NIH 3T3 Cells — Phosphorylation — Signal Transduction/physiology — EIF-2 Kinase/metabolism | |
| Identifiers | PMID: 14749731 | |
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| Citation (ISO format) | DONZE, Olivier et al. The protein kinase PKR: a molecular clock that sequentially activates survival and death programs. In: EMBO Journal, 2004, vol. 23, n° 3, p. 564-71. https://archive-ouverte.unige.ch/unige:4659 |
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