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Scientific article
English

Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol

Published inACS Medicinal Chemistry Letters, vol. 8, no. 12, p. 1304-1308
Publication date2017
Abstract

With ∼429,000 deaths in 2016, malaria remains a major infectious disease where the need to treat the fever symptoms, but also to provide relevant post-treatment prophylaxis, is of major importance. An azepanylcarbazole amino alcohol is disclosed with a long- and fast-acting in vivo antiplasmodial efficacy and meets numerous attributes of a desired post-treatment chemoprophylactic antimalarial agent. The synthesis, the parasitological characterization, and the animal pharmacokinetics and pharmacodynamics of this compound are presented along with a proposed target.

Keywords
  • Amino alcohol
  • Antiplasmodial
  • Carbazole
  • Hsp90
  • Pharmacodynamics
  • Pharmacokinetics
Research group
Citation (ISO format)
ABLA, Nada et al. Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol. In: ACS Medicinal Chemistry Letters, 2017, vol. 8, n° 12, p. 1304–1308. doi: 10.1021/acsmedchemlett.7b00391
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1948-5875
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Creation12/15/2017 4:08:00 PM
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