Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
ContributorsNeckers, Len; Blagg, Brian; Haystead, Timothy; Trepel, Jane B.; Whitesell, Luke; Picard, Didier
Published inCell Stress and Chaperones, vol. 23, no. 4, p. 467-482
Publication date2018
Abstract
Keywords
- Molecular chaperones
- Hsp90
- Inhibitors
- Off-target effects
- Secondary effects
- Hsf1
- Cancer
- Clinical trials
Affiliation entities
Research groups
Citation (ISO format)
NECKERS, Len et al. Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development. In: Cell Stress and Chaperones, 2018, vol. 23, n° 4, p. 467–482. doi: 10.1007/s12192-018-0877-2
Main files (2)
Article (Accepted version)
Article (Published version)
Identifiers
- PID : unige:114490
- DOI : 10.1007/s12192-018-0877-2
Commercial URLhttp://link.springer.com/10.1007/s12192-018-0877-2
ISSN of the journal1355-8145