Book chapter
English

Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis

Published inIsaacs, J & Whitesell, L. (Ed.), Hsp90 in Cancer: Beyond the Usual Suspects, p. 1-30
PublisherAcademic Press
Collection
  • Advances in Cancer Research; 129
Publication date2016
Abstract

The molecular chaperone Hsp90 has attracted a lot of interest in cancer research ever since cancer cells were found to be more sensitive to Hsp90 inhibition than normal cells. Why that is has remained a matter of debate and is still unclear. In addition to increased Hsp90 dependence for some mutant cancer proteins and modifications of the Hsp90 machinery itself, a number of other characteristics of cancer cells probably contribute to this phenomenon; these include aneuploidy and overall increased numbers and levels of defective and mutant proteins, which all contribute to perturbed proteostasis. Work over the last two decades has demonstrated that many cancer-related proteins are Hsp90 clients, and yet only few of them have been extensively investigated, selected either on the basis of their obvious function as cancer drivers or because they proved to be convenient biomarkers for monitoring the effects of Hsp90 inhibitors. The purpose of our review is to go beyond these "usual suspects." We established a workflow to select poorly studied proteins that are related to cancer processes and qualify as Hsp90 clients. By discussing and taking a fresh look at these "unusual suspects," we hope to stimulate others to revisit them as novel therapeutic targets or diagnostic markers.

Research groups
Citation (ISO format)
VARTHOLOMAIOU, Evangelia, ECHEVERRIA, Pablo Christian, PICARD, Didier. Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis. In: Hsp90 in Cancer: Beyond the Usual Suspects. Isaacs, J & Whitesell, L. (Ed.). [s.l.] : Academic Press, 2016. p. 1–30. (Advances in Cancer Research) doi: 10.1016/bs.acr.2015.08.001
Main files (1)
Book chapter (Published version)
accessLevelRestricted
Identifiers
ISBN9780128022900
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Technical informations

Creation10/03/2016 13:02:00
First validation10/03/2016 13:02:00
Update time15/03/2023 00:13:02
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