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Scientific article
English

Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells

Published inTrends in cell biology, vol. 24, no. 8, p. 455-463
Publication date2014
Abstract

Many tumors undergo a dramatic metabolic shift known as the Warburg effect in which glucose utilization is favored and oxidative phosphorylation is downregulated, even when oxygen availability is plentiful. However, the mechanistic basis for this switch has remained unclear. Recently several independent groups identified tumor necrosis factor receptor-associated protein 1 (TRAP1), a mitochondrial molecular chaperone of the heat shock protein 90 (Hsp90) family, as a key modulator of mitochondrial respiration. Although all reports agree that this activity of TRAP1 has important implications for neoplastic progression, data from the different groups only partially overlap, suggesting that TRAP1 may have complex and possibly contextual effects on tumorigenesis. In this review we analyze these recent findings and attempt to reconcile these observations.

Keywords
  • ROS
  • TRAP1
  • Cancer metabolism
  • Chaperones
  • Mitochondria
Research group
Citation (ISO format)
RASOLA, Andrea, NECKERS, Len, PICARD, Didier. Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells. In: Trends in cell biology, 2014, vol. 24, n° 8, p. 455–463. doi: 10.1016/j.tcb.2014.03.005
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Article (Published version)
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Identifiers
ISSN of the journal0962-8924
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Creation08/21/2014 3:56:00 PM
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