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Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility

Published in Biochimica et biophysica acta. 2010, vol. 1803, no. 6, p. 641-9
Abstract Steroid hormone receptors (SHRs) are notorious intracellular travellers, transiting among different cellular compartments as they mature, are subjected to regulation and exert their biological functions. Understanding the processes governing the intracellular traffic of SHRs is important, since their unbalanced or erroneous localization could lead to the development of diseases. In this review, we not only explore the functions of the heat-shock protein 90 (Hsp90) molecular chaperone machine for the intracellular transport of SHRs, but also for the regulation of their nuclear mobility, for their recycling and for the regulation of their transcriptional output.
Keywords AnimalsCell Nucleus/metabolismCytoplasm/metabolismFungi/metabolismGene DeletionHSP90 Heat-Shock Proteins/metabolismHumansLigandsMicrotubules/metabolismModels, BiologicalMolecular Chaperones/metabolismProtein BindingProtein TransportReceptors, Steroid/metabolism
PMID: 20006655
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ECHEVERRIA, Pablo Christian, PICARD, Didier. Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility. In: Biochimica et biophysica acta, 2010, vol. 1803, n° 6, p. 641-9. doi: 10.1016/j.bbamcr.2009.11.012 https://archive-ouverte.unige.ch/unige:17152

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Deposited on : 2011-10-11

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