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Aromatase overexpression enhances the stimulatory effects of adrenal androgens on MCF7 breast cancer cells

Maggiolini, Marcello
Bonofiglio, Daniela
Pezzi, Vincenzo
Carpino, Amalia
Marsico, Stefania
Rago, Vittoria
Vivacqua, Adele
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Published in Molecular and Cellular Endocrinology. 2002, vol. 193, no. 1-2, p. 13-8
Abstract The intratumoral conversion of adrenal androgens into estrogens by the aromatase enzyme complex may be an important mechanism of autocrine stimulation in hormone-dependent breast tumor. The effects of estrogens on tumor development are mediated by the activity of estrogen receptor alpha that induces gene expression and cell proliferation. Thus, estrogen biosynthesis 'in situ' and/or estrogen receptor action are the main targets of endocrine treatment in endocrine-dependent breast carcinoma. In the present study we demonstrate that three major adrenal androgens, dehydroepiandrosterone, 5-androstene-3beta, 17beta-diol and 4-androstene 3,17-dione, all acquire an estradiol-like biological efficacy in aromatase transfected MCF7 breast cancer cells. Our results suggest that in postmenopausal women aromatase inhibitors might be considered as an adjuvant approach to the treatment of hormone-dependent breast tumors that overexpress aromatase.
Keywords Adrenal Glands/chemistryAndrogens/pharmacologyAndrostenediol/pharmacologyAndrostenedione/pharmacologyAromatase/genetics/metabolism/physiologyBreast Neoplasms/metabolism/pathologyCell Division/drug effectsDehydroepiandrosterone/pharmacologyEstrogen Receptor alphaFemaleGene Expression Regulation/drug effectsHumansReceptors, Estrogen/drug effects/metabolismTransfectionTumor Cells, Cultured
PMID: 12160997
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MAGGIOLINI, Marcello et al. Aromatase overexpression enhances the stimulatory effects of adrenal androgens on MCF7 breast cancer cells. In: Molecular and Cellular Endocrinology, 2002, vol. 193, n° 1-2, p. 13-8. doi: 10.1016/S0303-7207(02)00091-6 https://archive-ouverte.unige.ch/unige:4629

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Deposited on : 2009-12-08

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