AK
Koval, Alexey
| Title | Published in | Access level | OA Policy | Year | Views | Downloads | |
|---|---|---|---|---|---|---|---|
| Signalomics for molecular tumor boards and precision oncology of breast and gynecological cancers | Molecular systems biology |  | 2025 | 62 | 33 | ||
| Loss of the conserved switch III region in a G protein leads to severe pediatric encephalopathy | Science signaling |  | 2025 | 13 | 0 | ||
| Clinical-molecular profiling of atypical GNAO1 patients : Novel pathogenic variants, unusual manifestations, and severe molecular dysfunction | Genes & diseases | | 2025 | 36 | 26 | ||
| Success and Controversy of Natural Products as Therapeutic Modulators of Wnt Signaling and Its Interplay with Oxidative Stress : Comprehensive Review Across Compound Classes and Experimental Systems | Antioxidants | | 2025 | 42 | 192 | ||
| Syndecan-2 positively regulates Wnt/β-catenin signaling in breast cancer cells | International journal of biochemistry & cell biology | | 2025 | 33 | 0 | ||
| Atypical GNAO1 variants in severe childhood speech disorders: clinical, genetic, and molecular insights | Molecular autism | | 2025 | 8 | 8 | ||
| Integration of Wnt-inhibitory activity and structural novelty scoring results to uncover novel bioactive natural products : new Bicyclo[3.3.1]non-3-ene-2,9-diones from the leaves of Hymenocardia punctata | Frontiers in chemistry | | 2024 | 120 | 92 | ||
| Germline mutations in a G protein identify signaling cross-talk in T cells | Science | | 2024 | 182 | 0 | ||
| Neomorphic Gαo mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies | The Journal of clinical investigation | | 2024 | 97 | 93 | ||
| Zinc for GNAO1 encephalopathy : preclinical profiling and a clinical case | Med | | 2024 | 126 | 205 | ||
| Challenging Reported Frizzled-Targeting Compounds in Selective Assays Reveals Lack of Functional Inhibition and Claimed Profiles | ACS pharmacology & translational science | | 2024 | 191 | 106 | ||
| Chemical and Biological Characterization of Metabolites from Silene viridiflora Using Mass Spectrometric and Cell-Based Assays | Biomolecules | | 2024 | 95 | 257 | ||
| Clinical and Molecular Profiling in GNAO1 Permits Phenotype–Genotype Correlation | Movement disorders | | 2024 | 99 | 149 | ||
| GNAO1 Mutations Affecting the N‐Terminal α‐Helix of Gαo Lead to Parkinsonism | Movement disorders | | 2024 | 113 | 197 | ||
| Cis-regulatory polymorphism at fiz ecdysone oxidase contributes to polygenic evolutionary response to malnutrition in Drosophila | PLOS genetics | | 2024 | 72 | 142 | ||
| Clinical Cases and the Molecular Profiling of a Novel Childhood Encephalopathy-Causing GNAO1 Mutation P170R | Cells | | 2023 | 110 | 48 | ||
| Wnt-Independent SARS-CoV-2 Infection in Pulmonary Epithelial Cells | Microbiology spectrum | | 2023 | 186 | 144 | ||
| Shallow- and deep-water Ophiura species produce a panel of chlorin compounds with potent photodynamic anticancer activities | Antioxidants | | 2023 | 242 | 74 | ||
| Clofazimine: a journey of a drug | Biomedicine & pharmacotherapy | | 2023 | 96 | 275 | ||
| In-depth molecular profiling of an intronic GNAO1 mutant as the basis for personalized high-throughput drug screening | Med | | 2023 | 134 | 1 | ||
| Pediatric GNAO1 encephalopathies: from molecular etiology of the disease to drug discovery | Neural Regeneration Research | | 2023 | 100 | 138 | ||
| Improved approaches to channel capacity estimation discover compromised GPCR signaling in diverse cancer cells | iScience | | 2023 | 91 | 61 | ||
| Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth | Nature communications | | 2022 | 374 | 240 | ||
| Wnt-pathway inhibitors with selective activity against triple-negative breast cancer: from thienopyrimidine to quinazoline inhibitors | Frontiers in pharmacology | | 2022 | 212 | 183 | ||
| Chemoenzymatic synthesis of complex phenylpropanoid derivatives by the Botrytis cinerea secretome and evaluation of their wnt inhibition activity | Frontiers in plant science | | 2022 | 305 | 162 | ||
| Chemoenzymatic synthesis of original stilbene dimers possessing wnt inhibition activity in triple-negative breast cancer cells using the enzymatic secretome of Botrytis cinerea pers | Frontiers in chemistry | | 2022 | 237 | 168 | ||
| Restoration of the GTPase activity and cellular interactions of Gαo mutants by Zn2+ in GNAO1 encephalopathy models | Science advances | | 2022 | 203 | 176 | ||
| Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation | Acta neuropathologica communications | | 2022 | 274 | 147 | ||
| Mining natural compounds to target WNT signaling: land and sea tales | Pharmacology of the WNT signaling system | | 2021 | 220 | 1 | ||
| Pediatric encephalopathy: cinical, biochemical and cellular insights into the role of Gln52 of GNAO1 and GNAI1 for the dominant disease | Cells | | 2021 | 403 | 201 | ||
| A cytotoxic porphyrin from North Pacific brittle star Ophiura sarsii | Marine Drugs | | 2021 | 492 | 234 | ||
| Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo | European Journal of Medicinal Chemistry | | 2021 | 284 | 176 | ||
| Unlocking the Wnt pathway: therapeutic potential of selective targeting FZD7 in cancer | Drug discovery today | | 2021 | 542 | 512 | ||
| Short stature and combined immunodeficiency associated with mutations in RGS10 | Science Signaling | | 2021 | 228 | 0 | ||
| Isolation and identification of isocoumarin derivatives with specific inhibitory activity against wnt pathway and metabolome characterization of lasiodiplodia venezuelensis | Frontiers in Chemistry | | 2021 | 367 | 468 | ||
| Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells | Communications Biology | | 2021 | 343 | 207 | ||
| Generation of stilbene antimicrobials against multiresistant strains of Staphylococcus aureus through biotransformation by the enzymatic secretome of Botrytis cinerea | Journal of Natural Products | | 2020 | 357 | 467 | ||
| Beyond TNBC: repositioning of clofazimine against a broad range of Wnt-dependent cancers | Frontiers in Oncology | | 2020 | 338 | 242 | ||
| Targeting the Wnt signalling pathway in cancer: prospects and perils | Swiss Medical Weekly | | 2019 | 596 | 346 | ||
| Chemo-diversification of plant extracts using a generic bromination reaction and monitoring by metabolite profiling | ACS Combinational Science | | 2019 | 406 | 0 | ||
| A high-throughput assay pipeline for specific targeting of frizzled GPCRs in cancer | Methods in Cell Biology |  | 2019 | 362 | 0 | ||
| Towards the first targeted therapy for triple-negative breast cancer: Repositioning of clofazimine as a chemotherapy-compatible selective Wnt pathway inhibitor | Cancer Letters | | 2019 | 1,147 | 484 | ||
| Dramatic dysbalancing of the Wnt pathway in breast cancers | Scientific Reports | | 2018 | 313 | 155 | ||
| High capacity in G protein-coupled receptor signaling | Nature Communications | | 2018 | 390 | 207 | ||
| Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts | Cancer Letters | | 2018 | 335 | 703 | ||
| High-throughput targeted screening in triple-negative breast cancer cells identifies Wnt-inhibiting activities in Pacific brittle stars | Scientific Reports | | 2017 | 397 | 206 | ||
| Golgi-Resident Gαo Promotes Protrusive Membrane Dynamics | Cell | | 2017 | 479 | 469 | ||
| Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition | BioFactors | | 2017 | 435 | 757 | ||
| Inhibition of Wnt signalling and breast tumour growth by the multi-purpose drug suramin through suppression of heterotrimeric G proteins and Wnt endocytosis | Biochemical Journal | | 2016 | 401 | 423 | ||
| A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers | Cancers | | 2016 | 412 | 341 |
