Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth
Published inNature communications, vol. 13, no. 1, 674
Publication date2022-02-03
First online date2022-02-03
Abstract
Keywords
- Animals
- Axin Protein / genetics
- Axin Protein / metabolism
- Cell Line, Tumor
- Cell Proliferation / drug effects
- Cell Proliferation / genetics
- Colorectal Neoplasms / genetics
- Colorectal Neoplasms / metabolism
- Colorectal Neoplasms / pathology
- Female
- GTP-Binding Protein alpha Subunit, Gi2 / genetics
- Gene Expression Regulation, Neoplastic
- Guanabenz / pharmacology
- HEK293 Cells
- Humans
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Nude
- Mutation
- Wnt Signaling Pathway / drug effects
- Wnt Signaling Pathway / genetics
- Xenograft Model Antitumor Assays / methods
- Beta Catenin / genetics
- Beta Catenin / metabolism
- GTP-Binding Protein alpha Subunit,Gi2/metabolism
- Adrenergic alpha-2 Receptor Agonists/pharmacology
Affiliation entities
Research groups
Citation (ISO format)
MIETE, Cezanne et al. Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth. In: Nature communications, 2022, vol. 13, n° 1, p. 674. doi: 10.1038/s41467-022-28286-9
Main files (1)
Article (Published version)
Secondary files (14)
Identifiers
- PID : unige:160123
- DOI : 10.1038/s41467-022-28286-9
- PMID : 35115535
- PMCID : PMC8814139
ISSN of the journal2041-1723