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A cytotoxic porphyrin from North Pacific brittle star Ophiura sarsii

Khotimchenko, Yuri S.
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Published in Marine drugs. 2021, vol. 19, no. 1, E11
Abstract Triple-negative breast cancer (TNBC) represents the deadliest form of gynecological tumors currently lacking targeted therapies. The ethanol extract of the North Pacific brittle star Ophiura sarsii presented promising anti-TNBC activities. After elimination of the inert material, the active extract was submitted to a bioguided isolation approach using high-resolution semipreparative HPLC-UV, resulting in one-step isolation of an unusual porphyrin derivative possessing strong cytotoxic activity. HRMS and 2D NMR resulted in the structure elucidation of the compound as (3S,4S)-14-Ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid. Never identified before in Ophiuroidea, porphyrins have found broad applications as photosensitizers in the anticancer photodynamic therapy. The simple isolation of a cytotoxic porphyrin from an abundant brittle star species we describe here may pave the way for novel natural-based developments of targeted anti-cancer therapies.
PMID: 33383654
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Other version: https://www.mdpi.com/1660-3397/19/1/11
Research groups Phytochimie et produits naturels bioactifs
Voies de signalisation oncogéniques (998)
Swiss National Science Foundation: R'Equip grant 316030_164095
(ISO format)
KLIMENKO, Antonina et al. A cytotoxic porphyrin from North Pacific brittle star Ophiura sarsii. In: Marine Drugs, 2021, vol. 19, n° 1, p. E11. doi: 10.3390/md19010011 https://archive-ouverte.unige.ch/unige:147020

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Deposited on : 2021-01-08

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