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Scientific article
Open access
English

A cytotoxic porphyrin from North Pacific brittle star Ophiura sarsii

Published inMarine Drugs, vol. 19, no. 1, E11
Publication date2021
Abstract

Triple-negative breast cancer (TNBC) represents the deadliest form of gynecological tumors currently lacking targeted therapies. The ethanol extract of the North Pacific brittle star Ophiura sarsii presented promising anti-TNBC activities. After elimination of the inert material, the active extract was submitted to a bioguided isolation approach using high-resolution semipreparative HPLC-UV, resulting in one-step isolation of an unusual porphyrin derivative possessing strong cytotoxic activity. HRMS and 2D NMR resulted in the structure elucidation of the compound as (3S,4S)-14-Ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid. Never identified before in Ophiuroidea, porphyrins have found broad applications as photosensitizers in the anticancer photodynamic therapy. The simple isolation of a cytotoxic porphyrin from an abundant brittle star species we describe here may pave the way for novel natural-based developments of targeted anti-cancer therapies.

Funding
  • Swiss National Science Foundation - R'Equip grant 316030_164095
Citation (ISO format)
KLIMENKO, Antonina et al. A cytotoxic porphyrin from North Pacific brittle star Ophiura sarsii. In: Marine Drugs, 2021, vol. 19, n° 1, p. E11. doi: 10.3390/md19010011
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Article (Published version)
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Identifiers
ISSN of the journal1660-3397
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