Isolation and identification of isocoumarin derivatives with specific inhibitory activity against wnt pathway and metabolome characterization of lasiodiplodia venezuelensis

Pellissier, Léonie; Koval, Alexey; Marcourt, Laurence; Ferreira Queiroz, Emerson; Lecoultre, Nicole; Leoni, Sara; Quiros Guerrero, Luis; Barthélémy, Morgane; Duivelshof, Bastiaan; Guillarme, Davy; Tardy, Sébastien; Eparvier, Véronique; Perron, Karl; Chave, Jérôme; Stien, Didier; Gindro, Katia; Katanaev, Vladimir; Wolfender, Jean-Luc

doi:10.3389/fchem.2021.664489

Scientific article

English

Isolation and identification of isocoumarin derivatives with specific inhibitory activity against wnt pathway and metabolome characterization of lasiodiplodia venezuelensis

Published inFrontiers in Chemistry, vol. 9, 664489

Publication date2021

Keywords

Natural product
Wnt pathway inhibitors
Anticancer
Lasiodiplodia venezuelensis
Endophytic fungi
Bioguided
Fractionation
Isocoumarins
Molecular networking

Affiliation entities

Faculté des sciences / Section de biologie / Département des sciences végétales
Faculté des sciences / Section des sciences pharmaceutiques
Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Research groups

Funding

Swiss National Science Foundation - SECIL, ref ANR-15-CE21-0016
Swiss National Science Foundation - Study of leaf endophytic fungi: Exploration and valorization of biosourCed Innovative antibacterial metaboLites

Citation (ISO format)

PELLISSIER, Léonie et al. Isolation and identification of isocoumarin derivatives with specific inhibitory activity against wnt pathway and metabolome characterization of lasiodiplodia venezuelensis. In: Frontiers in Chemistry, 2021, vol. 9, p. 664489. doi: 10.3389/fchem.2021.664489