When Bacterial Culture Fails, Metagenomics Can Help: A Case of Chronic Hepatic Brucelloma Assessed by Next-Generation Sequencing

Lazarevic, Vladimir; Gaia, Nadia; Girard, Myriam; Leo, Stefano; Cherkaoui, Abdessalam; Renzi, Gesuele; Emonet, Stéphane; Jamme, Sharon; Ruppe, Etienne; Vijgen, Sandrine Elisabeth V; Rubbia-Brandt, Laura; Toso, Christian; Schrenzel, Jacques

doi:10.3389/fmicb.2018.01566

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Title		When Bacterial Culture Fails, Metagenomics Can Help: A Case of Chronic Hepatic Brucelloma Assessed by Next-Generation Sequencing
Authors		Lazarevic, Vladimir Gaia, Nadia Girard, Myriam Leo, Stefano Cherkaoui, Abdessalam Renzi, Gesuele Emonet, Stéphane Jamme, Sharon Ruppe, Etienne Vijgen, Sandrine Elisabeth V Rubbia-Brandt, Laura Toso, Christian Schrenzel, Jacques show all authors [1 - 13]
Published in		Frontiers in Microbiology. 2018, vol. 9, p. 1566
Abstract		Here, we sequenced DNA extracted from a necrotic hepatic lesion from a patient with suspected chronic hepatic brucelloma but negative culture results. Although most of the taxonomically classified sequencing reads corresponded to human genome sequences, our data suggest that whole-metagenome shotgun sequencing may be used together with other tests to strengthen the diagnosis of hepatic brucelloma.
Identifiers		DOI: 10.3389/fmicb.2018.01566 PMID: 30065706
Full text		Article (Published version) (732 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research groups		Métastases du foie (657) Transplantation et hépatologie (905) Analyse génomique et fonctionnelle du staphylocoque doré (604)
Citation (ISO format)		LAZAREVIC, Vladimir et al. When Bacterial Culture Fails, Metagenomics Can Help: A Case of Chronic Hepatic Brucelloma Assessed by Next-Generation Sequencing. In: Frontiers in Microbiology, 2018, vol. 9, p. 1566. doi: 10.3389/fmicb.2018.01566 https://archive-ouverte.unige.ch/unige:112939