In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice

Hu He, Kai Hui; Lorenzo, Petra I; Brun, Thierry; Jimenez Moreno, Carmen M; Aeberhard, Deborah; Vallejo Ortega, Jorge; Cornu, Marion; Thorel, Fabrizio; Gjinovci, Asllan; Thorens, Bernard; Herrera, Pedro Luis; Meda, Paolo; Wollheim, Claes; Gauthier, Benoît

doi:10.2337/db10-1102

Scientific article

English

In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice

ContributorsHu He, Kai Hui; Lorenzo, Petra I; Brun, Thierry

; Jimenez Moreno, Carmen M; Aeberhard, Deborah; Vallejo Ortega, Jorge; Cornu, Marion; Thorel, Fabrizio; Gjinovci, Asllan; Thorens, Bernard; Herrera, Pedro Luis

; Meda, Paolo; Wollheim, Claes; Gauthier, Benoît

Published inDiabetes, vol. 60, no. 6, p. 1705-1715

Publication date2011

Abstract

To establish the role of the transcription factor Pax4 in pancreatic islet expansion and survival in response to physiological stress and its impact on glucose metabolism, we generated transgenic mice conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (Pax4R129W) in β-cells.

Keywords

Animals
Apoptosis/genetics/physiology
Cyclin-Dependent Kinase 4/genetics/metabolism
Cytochromes c/genetics/metabolism
Glucose Transporter Type 2/genetics/metabolism
Homeodomain Proteins/genetics/metabolism
Hyperglycemia/chemically induced/metabolism/prevention & control
Immunoblotting
Immunohistochemistry
Insulin/genetics/metabolism
Insulin-Secreting Cells/cytology/metabolism
Maf Transcription Factors, Large/genetics/metabolism
Mice
Mice, Transgenic
Paired Box Transcription Factors/genetics/metabolism
Polymerase Chain Reaction
Proto-Oncogene Proteins c-bcl-2/genetics/metabolism
Proto-Oncogene Proteins c-myc/genetics/metabolism
Streptozocin/toxicity
Stress, Physiological/physiology

Affiliation entities

Research groups

Citation (ISO format)

HU HE, Kai Hui et al. In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice. In: Diabetes, 2011, vol. 60, n° 6, p. 1705–1715. doi: 10.2337/db10-1102

Article (Published version)

Identifiers

PID : unige:25005
DOI : 10.2337/db10-1102
PMID : 21521872

Journal ISSN0012-1797

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Update14/03/2023 19:53:29

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In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice

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