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Scientific article
Open access
English

In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice

Published inDiabetes, vol. 60, no. 6, p. 1705-1715
Publication date2011
Abstract

To establish the role of the transcription factor Pax4 in pancreatic islet expansion and survival in response to physiological stress and its impact on glucose metabolism, we generated transgenic mice conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (Pax4R129W) in β-cells.

Keywords
  • Animals
  • Apoptosis/genetics/physiology
  • Cyclin-Dependent Kinase 4/genetics/metabolism
  • Cytochromes c/genetics/metabolism
  • Glucose Transporter Type 2/genetics/metabolism
  • Homeodomain Proteins/genetics/metabolism
  • Hyperglycemia/chemically induced/metabolism/prevention & control
  • Immunoblotting
  • Immunohistochemistry
  • Insulin/genetics/metabolism
  • Insulin-Secreting Cells/cytology/metabolism
  • Maf Transcription Factors, Large/genetics/metabolism
  • Mice
  • Mice, Transgenic
  • Paired Box Transcription Factors/genetics/metabolism
  • Polymerase Chain Reaction
  • Proto-Oncogene Proteins c-bcl-2/genetics/metabolism
  • Proto-Oncogene Proteins c-myc/genetics/metabolism
  • Streptozocin/toxicity
  • Stress, Physiological/physiology
Citation (ISO format)
HU HE, Kai Hui et al. In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice. In: Diabetes, 2011, vol. 60, n° 6, p. 1705–1715. doi: 10.2337/db10-1102
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0012-1797
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1558downloads

Technical informations

Creation10/24/2012 6:25:00 PM
First validation10/24/2012 6:25:00 PM
Update time03/14/2023 7:53:29 PM
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