In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice

Article Article scientifique Article In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice eng 2011 author Hu He Kai Hui author Lorenzo Petra I author Brun Thierry 0000-0002-1659-4283 24644 author Jimenez Moreno Carmen M author Aeberhard Deborah 649940 author Vallejo Ortega Jorge author Cornu Marion author Thorel Fabrizio 501462 author Gjinovci Asllan author Thorens Bernard 639542 author Herrera Pedro Luis 0000-0003-0771-9504 23981 author Meda Paolo 26346 author Wollheim Claes 25195 author Gauthier Benoît 129022 1705-1715 10.2337/db10-1102 21521872 0012-1797 To establish the role of the transcription factor Pax4 in pancreatic islet expansion and survival in response to physiological stress and its impact on glucose metabolism, we generated transgenic mice conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (Pax4R129W) in β-cells. Animals Apoptosis/genetics/physiology Cyclin-Dependent Kinase 4/genetics/metabolism Cytochromes c/genetics/metabolism Glucose Transporter Type 2/genetics/metabolism Homeodomain Proteins/genetics/metabolism Hyperglycemia/chemically induced/metabolism/prevention & control Immunoblotting Immunohistochemistry Insulin/genetics/metabolism Insulin-Secreting Cells/cytology/metabolism Maf Transcription Factors, Large/genetics/metabolism Mice Mice, Transgenic Paired Box Transcription Factors/genetics/metabolism Polymerase Chain Reaction Proto-Oncogene Proteins c-bcl-2/genetics/metabolism Proto-Oncogene Proteins c-myc/genetics/metabolism Streptozocin/toxicity Stress, Physiological/physiology Dewey 576.5 Dewey 612 134 Département de physiologie cellulaire et métabolisme 21C 135 Département de médecine génétique et développement 21D false 107 Couplage cellulaire et connexines 136 272 Types cellulaires pancréatiques pendant l'ontogénèse 522 Diabetes 60 6 4cc4b23e-5ab2-45cf-b76c-dd303233361b Article (Published version) Public kaireprint.pdf 1925637 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

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In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice	Diabetes			2011	709	1,593

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Aeberhard, Deborah