Background: Clinical reasoning is a complex process that is central to medical practice. GPs who follow patients with multimorbidities have to combine several roles in their care. Metaphors are a language tool that potentially provides access to the clinical reasoning behind this management. Aim: To analyse the metaphors expressed by GPs to better understand their clinical reasoning. Methods: Nine general practitioners (5 women and 4 men) aged between 29 and 57 years participated in the study. Non-directive interviews were conducted, transcribed and analysed using Schmitt’s systematic metaphor analysis framework. Results: Seven metaphorical themes. Within these metaphorical themes, GPs described their clinical reasoning processes in the face of multimorbidity as (1) a building process, (2) a sudoku or puzzle, (3) an Odyssey, (4) a story with someone, (5) a race, (6) looking at a painting, and (7) playing a tune. Conclusion: The metaphors may highlight the complexity of the clinical reasoning process of general practitioners in the long-term management of patients suffering from multimorbidity and support a deeper understanding and awareness.