Gut barrier and microbiota changes with glycine and branched‐chain amino acid supplementation in chronic haemodialysis patients

Genton Graf, Laurence; Pruijm, Menno; Teta, Daniel; Bassi, Isabelle; Cani, Patrice D.; Gaia, Nadia; Herrmann, François; Marangon, Nicola Danièle Armando; Mareschal, Julie; Muccioli, Giulio G.; Stoermann Chopard, Catherine Augusta; Suriano, Francesco; Wurzner‐Ghajarzadeh, Arlene; Lazarevic, Vladimir; Schrenzel, Jacques

doi:10.1002/jcsm.12781

Scientific article

English

Gut barrier and microbiota changes with glycine and branched‐chain amino acid supplementation in chronic haemodialysis patients

ContributorsGenton Graf, Laurence

; Pruijm, Menno; Teta, Daniel; Bassi, Isabelle; Cani, Patrice D.; Gaia, Nadia; Herrmann, François; Marangon, Nicola Danièle Armando; Mareschal, Julie; Muccioli, Giulio G.; Stoermann Chopard, Catherine Augusta; Suriano, Francesco; Wurzner‐Ghajarzadeh, Arlene; Lazarevic, Vladimir

; Schrenzel, Jacques

Published inJournal of cachexia, sarcopenia and muscle

First online date2021-09-18

Abstract

Background: We have previously shown that glycine increases fat-free mass in chronic haemodialysis patients with features of malnutrition as compared with branched-chain amino acids (BCAAs). This multicentre randomized double-blind crossover study evaluates the impact of these amino acids on the gut barrier and microbiota.

Keywords

Appetite
Branched-chain amino acid malnutrition
Endocannabinoids
Glycine
Gut microbiota

UNIGE affiliation entities

UNIGE research groups

Funding

Swiss National Science Foundation - Do branched chain amino acids counteract protein energy wasting through gut microbiota changes in hemodialysis patients? [320030_163144]

Citation (ISO format)

GENTON GRAF, Laurence et al. Gut barrier and microbiota changes with glycine and branched‐chain amino acid supplementation in chronic haemodialysis patients. In: Journal of cachexia, sarcopenia and muscle, 2021. doi: 10.1002/jcsm.12781

Article (Published version)

CC BY-4.0

Supplemental data

Identifiers

PID : unige:157263
DOI : 10.1002/jcsm.12781
PMID : 34535959

Additional URL for this publicationhttps://onlinelibrary.wiley.com/doi/10.1002/jcsm.12781

Datasets

https://clinicaltrials.gov/ct2/show/NCT02962089

Journal ISSN2190-5991

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Creation03/12/2021 15:27:00

First validation03/12/2021 15:27:00

Update31/01/2025 16:27:47

Status update31/01/2025 16:27:47

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Gut barrier and microbiota changes with glycine and branched‐chain amino acid supplementation in chronic haemodialysis patients

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