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Early termination of a prospective, randomized trial comparing teicoplanin and flucloxacillin for treating severe staphylococcal infections

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Published in Journal of Infectious Diseases. 1987, vol. 155, no. 2, p. 187-191
Abstract In a prospective, randomized trial, teicoplanin (at a 400-mg intravenous loading dose followed by 200 mg/day intravenously or intramuscularly) was compared with flucloxacillin (8 g/day) in patients with severe staphylococcal infections. Teicoplanin proved unsatisfactory for the following reasons: failures or relapses were more frequent in the teicoplanin group, and blood levels were difficult to predict and tended to be low 24 hr after the loading dose. Future trials with this agent should use much-higher doses.
Keywords AdultAgedAged, 80 and overAnti-Bacterial Agents/ therapeutic useClinical Trials as TopicCloxacillin/ analogs & derivativesFloxacillin/administration & dosage/ therapeutic useGlycopeptides/administration & dosage/blood/therapeutic useHumansMiddle AgedProspective StudiesRandom AllocationStaphylococcal Infections/ drug therapyStaphylococcus/drug effectsStaphylococcus aureus/drug effectsTeicoplanin
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PMID: 2949024
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Other version: http://www.jstor.org/stable/pdfplus/30105792.pdf
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CALAIN, Philippe et al. Early termination of a prospective, randomized trial comparing teicoplanin and flucloxacillin for treating severe staphylococcal infections. In: Journal of Infectious Diseases, 1987, vol. 155, n° 2, p. 187-191. https://archive-ouverte.unige.ch/unige:7129

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Deposited on : 2010-06-21

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