Scientific article
Open access

Clustering of HCV coinfections on HIV phylogeny indicates domestic and sexual transmission of HCV

Published inInternational journal of epidemiology, vol. 43, no. 3, p. 887-896
Publication date2014

Background: HCV coinfection remains a major cause of morbidity and mortality among HIV-infected individuals and its incidence has increased dramatically in HIV-infected men who have sex with men(MSM). Methods: Hepatitis C virus (HCV) coinfection in the Swiss HIV Cohort Study(SHCS) was studied by combining clinical data with HIV-1 pol-sequences from the SHCS Drug Resistance Database(DRDB). We inferred maximum-likelihood phylogenetic trees, determined Swiss HIV-transmission pairs as monophyletic patient pairs, and then considered the distribution of HCV on those pairs. Results: Among the 9748 patients in the SHCS-DRDB with known HCV status, 2768(28%)were HCV-positive. Focusing on subtype B(7644 patients), we identified 1555 potential HIV-1 transmission pairs. There, we found that, even after controlling for transmission group, calendar year, age and sex, the odds for an HCV coinfection were ncreased by an odds ratio (OR) of 3.2 (95% confidence interval (CI) 2.2, 4.7) if a patient clustered with another HCV-positive case. This strong association persisted if transmission groups of intravenous drug users (IDUs), MSMs and heterosexuals (HETs) were considered separately(in all cases OR >2). Finally we found that HCV incidence was increased by a hazard ratio of 2.1 (1.1, 3.8) for individuals paired with an HCV-positive partner. Conclusions: Patients whose HIV virus is closely related to the HIV virus of HIV/HCVcoinfected patients have a higher risk for carrying or acquiring HCV themselves. This indicates the occurrence of domestic and sexual HCV transmission and allows the identification of patients with a high HCV-infection risk.

  • HIV-HCV coinfection, molecular epidemiology, genotypic resistance testing, sexual transmission of HCV
Citation (ISO format)
KOUYOS, R. D. et al. Clustering of HCV coinfections on HIV phylogeny indicates domestic and sexual transmission of HCV. In: International journal of epidemiology, 2014, vol. 43, n° 3, p. 887–896. doi: 10.1093/ije/dyt276
Main files (1)
Article (Published version)
ISSN of the journal0300-5771

Technical informations

Creation06/11/2014 11:37:00 AM
First validation06/11/2014 11:37:00 AM
Update time03/14/2023 9:23:40 PM
Status update03/14/2023 9:23:40 PM
Last indexation05/02/2024 3:21:35 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack