Clustering of HCV coinfections on HIV phylogeny indicates domestic and sexual transmission of HCV

Article Article scientifique Article Clustering of HCV coinfections on HIV phylogeny indicates domestic and sexual transmission of HCV eng 2014 author Kouyos R. D. author Rauch Anna 701527 author Boni Jose-Perol 750666 author Yerly Ferrillo Sabine 23752 author Shah Chandrika 516135 author Aubert Vincent 631518 author Klimkait T. author Kovari H. author Calmy Alexandra 0000-0002-1137-6826 41032 author Cavassini M. author Battegay M. author Vernazza P. L. author Bernasconi Enos 663410 author Ledergerber B. author Gunthard H. F. collaborator Burton-Jeangros Claudine 0000-0003-2258-9728 29914 collaborator Hirschel Bernard 22746 collaborator Kaiser Laurent 28229 collaborator Martinez De Tejada Weber Begona 590919 Swiss HIV Cohort Study 887-896 10.1093/ije/dyt276 24453237 0300-5771 Background: HCV coinfection remains a major cause of morbidity and mortality among HIV-infected individuals and its incidence has increased dramatically in HIV-infected men who have sex with men(MSM). Methods: Hepatitis C virus (HCV) coinfection in the Swiss HIV Cohort Study(SHCS) was studied by combining clinical data with HIV-1 pol-sequences from the SHCS Drug Resistance Database(DRDB). We inferred maximum-likelihood phylogenetic trees, determined Swiss HIV-transmission pairs as monophyletic patient pairs, and then considered the distribution of HCV on those pairs. Results: Among the 9748 patients in the SHCS-DRDB with known HCV status, 2768(28%)were HCV-positive. Focusing on subtype B(7644 patients), we identified 1555 potential HIV-1 transmission pairs. There, we found that, even after controlling for transmission group, calendar year, age and sex, the odds for an HCV coinfection were ncreased by an odds ratio (OR) of 3.2 (95% confidence interval (CI) 2.2, 4.7) if a patient clustered with another HCV-positive case. This strong association persisted if transmission groups of intravenous drug users (IDUs), MSMs and heterosexuals (HETs) were considered separately(in all cases OR >2). Finally we found that HCV incidence was increased by a hazard ratio of 2.1 (1.1, 3.8) for individuals paired with an HCV-positive partner. Conclusions: Patients whose HIV virus is closely related to the HIV virus of HIV/HCVcoinfected patients have a higher risk for carrying or acquiring HCV themselves. This indicates the occurrence of domestic and sexual HCV transmission and allows the identification of patients with a high HCV-infection risk. HIV-HCV coinfection, molecular epidemiology, genotypic resistance testing, sexual transmission of HCV Dewey 616 56 Département de médecine 221 false 400 Groupe Laurent Kaiser (virologie clinique) 668 International journal of epidemiology 43 3 64c9e451-3070-4279-893b-ad1d8fbf25fd Article (Published version) Public Kouyos RD_Clustering HCV coinfections HIV phylogeny indicates domestic sexual transmission HCV.pdf 427242 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Rauch, Anna