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Title

Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo

Authors
Uhles, S
Bénardeau, A
Prummer, M
Brecheisen, M
Sewing, S
Tobalina, L
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Published in Diabetes, Obesity and Metabolism. 2011, vol. 13, no. 4, p. 326-36
Abstract Glucagon-like peptide-1 (GLP-1) has protective effects on pancreatic β-cells. We evaluated the effects of a novel, long-acting human GLP-1 analogue, taspoglutide, on β-cells in vitro and in vivo.
Keywords AnimalsApoptosisCells, CulturedDeoxyuridine/analogs & derivativesDiabetes Mellitus, Type 2/drug therapy/pathologyGlucagon-Like Peptide 1/administration & dosage/analogs & derivatives/pharmacologyHumansImmunohistochemistryInsulin-Secreting Cells/drug effects/pathology/physiologyMalePeptides/administration & dosage/pharmacologyRatsRats, ZuckerReceptors, Glucagon/administration & dosage
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PMID: 21205124
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Research group La transplantation d'îlots de Langerhans (623)
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UHLES, S et al. Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo. In: Diabetes, Obesity and Metabolism, 2011, vol. 13, n° 4, p. 326-36. https://archive-ouverte.unige.ch/unige:25288

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Deposited on : 2013-01-10

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