Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo

Uhles, S; Wang, Haiyan; Bénardeau, A; Prummer, M; Brecheisen, M; Sewing, S; Tobalina, L; Bosco, Domenico; Wollheim, Claes; Migliorini, C; Sebokova, E

doi:10.1111/j.1463-1326.2010.01352.x

Scientific article

English

Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo

ContributorsUhles, S; Wang, Haiyan; Bénardeau, A; Prummer, M; Brecheisen, M; Sewing, S; Tobalina, L; Bosco, Domenico; Wollheim, Claes; Migliorini, C; Sebokova, E

Published inDiabetes, obesity & metabolism, vol. 13, no. 4, p. 326-336

Publication date2011

Abstract

Glucagon-like peptide-1 (GLP-1) has protective effects on pancreatic β-cells. We evaluated the effects of a novel, long-acting human GLP-1 analogue, taspoglutide, on β-cells in vitro and in vivo.

Keywords

Animals
Apoptosis
Cells, Cultured
Deoxyuridine/analogs & derivatives
Diabetes Mellitus, Type 2/drug therapy/pathology
Glucagon-Like Peptide 1/administration & dosage/analogs & derivatives/pharmacology
Humans
Immunohistochemistry
Insulin-Secreting Cells/drug effects/pathology/physiology
Male
Peptides/administration & dosage/pharmacology
Rats
Rats, Zucker
Receptors, Glucagon/administration & dosage

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

La transplantation d'îlots de Langerhans (623)

Citation (ISO format)

UHLES, S et al. Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo. In: Diabetes, obesity & metabolism, 2011, vol. 13, n° 4, p. 326–336. doi: 10.1111/j.1463-1326.2010.01352.x

Article (Published version)

Identifiers

PID : unige:25288
DOI : 10.1111/j.1463-1326.2010.01352.x
PMID : 21205124

Journal ISSN1462-8902

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Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo

Glucagon-like peptide-1 (GLP-1) has protective effects on pancreatic β-cells. We evaluated the effects of a novel, long-acting human GLP-1 analogue, taspoglutide, on β-cells in vitro and in vivo.

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