en
Scientific article
Open access
English

Brain functional connectivity alterations associated with neuropsychological performance 6–9 months following SARS‐CoV ‐2 infection

Published inHuman brain mapping, vol. 44, no. 4, p. 1629-1646
Publication date2023-03
First online date2022-12-02
Abstract

Neuropsychological deficits and brain damage following SARS-CoV-2 infection are not well understood. Then, 116 patients, with either severe, moderate, or mild disease in the acute phase underwent neuropsychological and olfactory tests, as well as completed psychiatric and respiratory questionnaires at 223 ± 42 days postinfection. Additionally, a subgroup of 50 patients underwent functional magnetic resonance imaging. Patients in the severe group displayed poorer verbal episodic memory performances, and moderate patients had reduced mental flexibility. Neuroimaging revealed patterns of hypofunctional and hyperfunctional connectivities in severe patients, while only hyperconnectivity patterns were observed for moderate. The default mode, somatosensory, dorsal attention, subcortical, and cerebellar networks were implicated. Partial least squares correlations analysis confirmed specific association between memory, executive functions performances and brain functional connectivity. The severity of the infection in the acute phase is a predictor of neuropsychological performance 6–9 months following SARS-CoV-2 infection. SARS-CoV-2 infection causes long-term memory and executive dysfunctions, related to large-scale functional brain connectivity alterations.

eng
Keywords
  • COVID-19
  • MRI
  • Cognition
  • Functional connectivity
  • Neuropsychological deficits
Citation (ISO format)
VORUZ, Philippe et al. Brain functional connectivity alterations associated with neuropsychological performance 6–9 months following SARS‐CoV ‐2 infection. In: Human brain mapping, 2023, vol. 44, n° 4, p. 1629–1646. doi: 10.1002/hbm.26163
Main files (1)
Article (Published version)
Secondary files (1)
Identifiers
ISSN of the journal1065-9471
68views
11downloads

Technical informations

Creation12/07/2022 11:18:50 AM
First validation05/26/2023 1:54:21 PM
Update time06/30/2023 10:23:55 AM
Status update06/30/2023 10:23:55 AM
Last indexation02/01/2024 10:09:53 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack