Brain functional connectivity alterations associated with neuropsychological performance 6

Article Article scientifique Article Brain functional connectivity alterations associated with neuropsychological performance 6–9 months following SARS‐CoV ‐2 infection eng 2022-12-02 2023-03 author Voruz Philippe 0000-0001-6796-8807 Clinical and Experimental Neuropsychology Laboratory, Faculty of Psychology University of Geneva Geneva Switzerland 804968 Section de psychologie (PSICO) author Cionca Alexandre 0000-0002-1910-9650 Clinical and Experimental Neuropsychology Laboratory, Faculty of Psychology University of Geneva Geneva Switzerland 973225 Section de psychologie (PSICO) author Jacot De Alcantara Isabele Harumi 0000-0002-2033-6287 Clinical and Experimental Neuropsychology Laboratory, Faculty of Psychology University of Geneva Geneva Switzerland 837619 Section de psychologie (PSICO) author Nuber-Champier Anthony Clinical and Experimental Neuropsychology Laboratory, Faculty of Psychology University of Geneva Geneva Switzerland 875567 Section de psychologie (PSICO) Anthony Nuber author Allali Gilles Department of Clinical Neurosciences, Neurology Department Geneva University Hospitals Geneva Switzerland 507314 Département des neurosciences cliniques (OTONO) author Benzakour Lamyae Faculty of Medicine University of Geneva Geneva Switzerland 889158 author Lalive d'Epinay Patrice Department of Clinical Neurosciences, Neurology Department Geneva University Hospitals Geneva Switzerland 636926 Département des neurosciences cliniques (OTONO) author Lövblad Karl-Olof Faculty of Medicine University of Geneva Geneva Switzerland 135154 Département de radiologie et informatique médicale (RADIO) author Braillard Olivia Thanh-Lan Division and Department of Primary Care Medicine Geneva University Hospitals Geneva Switzerland 543059 author Nehme Mayssam Division and Department of Primary Care Medicine Geneva University Hospitals Geneva Switzerland 840942 author Coen Matteo 0000-0002-6156-1691 Division of General Internal Medicine, Department of Medicine Geneva University Hospitals and Geneva University Geneva Switzerland 601519 Département de médecine (DEMED) author Serratrice Jacques Division of General Internal Medicine, Department of Medicine Geneva University Hospitals and Geneva University Geneva Switzerland 836481 Département de médecine (DEMED) author Reny Jean-Luc 0000-0002-7528-7363 Division of General Internal Medicine, Department of Medicine Geneva University Hospitals and Geneva University Geneva Switzerland 704339 Département de médecine (DEMED) author Pugin Jérôme Faculty of Medicine University of Geneva Geneva Switzerland 69624 Département d'anesthésiologie, pharmacologie et soins intensifs (APSIC) author Guessous Idris Faculty of Medicine University of Geneva Geneva Switzerland 760565 Médecine de premier recours hospitalo-universitaire (MPRHU) author Ptak Radek 0000-0003-4708-9201 Faculty of Medicine University of Geneva Geneva Switzerland 128547 Département des neurosciences cliniques (OTONO) author Landis Basile Nicolas Faculty of Medicine University of Geneva Geneva Switzerland 133537 Département des neurosciences cliniques (OTONO) author Adler Daniel Division of Pulmonary Diseases Geneva University Hospitals Geneva Switzerland 71621 author Griffa Alessandra 0000-0003-1923-1653 Department of Clinical Neurosciences, Neurology Department Geneva University Hospitals Geneva Switzerland 926719 author Van De Ville Dimitri 0000-0002-2879-3861 Faculty of Medicine University of Geneva Geneva Switzerland 638484 Département de radiologie et informatique médicale (RADIO) author Assal Frédéric Department of Clinical Neurosciences, Neurology Department Geneva University Hospitals Geneva Switzerland 527005 Département des neurosciences cliniques (OTONO) author Peron Julie Anne Clinical and Experimental Neuropsychology Laboratory, Faculty of Psychology University of Geneva Geneva Switzerland 705680 Section de psychologie (PSICO) 1629-1646 10.1002/hbm.26163 36458984 1065-9471 https://onlinelibrary.wiley.com/doi/10.1002/hbm.26163 Neuropsychological deficits and brain damage following SARS-CoV-2 infection are not well understood. Then, 116 patients, with either severe, moderate, or mild disease in the acute phase underwent neuropsychological and olfactory tests, as well as completed psychiatric and respiratory questionnaires at 223 ± 42 days postinfection. Additionally, a subgroup of 50 patients underwent functional magnetic resonance imaging. Patients in the severe group displayed poorer verbal episodic memory performances, and moderate patients had reduced mental flexibility. Neuroimaging revealed patterns of hypofunctional and hyperfunctional connectivities in severe patients, while only hyperconnectivity patterns were observed for moderate. The default mode, somatosensory, dorsal attention, subcortical, and cerebellar networks were implicated. Partial least squares correlations analysis confirmed specific association between memory, executive functions performances and brain functional connectivity. The severity of the infection in the acute phase is a predictor of neuropsychological performance 6–9 months following SARS-CoV-2 infection. SARS-CoV-2 infection causes long-term memory and executive dysfunctions, related to large-scale functional brain connectivity alterations. COVID-19 MRI Cognition Functional connectivity Neuropsychological deficits Dewey 616.8 Dewey 616.89 Dewey 613 Dewey 616.0757 Dewey 616 Dewey 150 Dewey 617 Dewey 618.97 Swiss National Science Foundation Short- and long-term neuropsychological impairment following COVID-19 198438 CH Programmes 62 Département de radiologie et informatique médicale 227 61 Département des neurosciences cliniques 226 108 Section de psychologie 71 60 Département de psychiatrie 225 64 Département de santé et médecine communautaires 22A 56 Département de médecine 221 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 65 Département de réadaptation et gériatrie 22B false 470 Ischémie cérébrale et connectivité 801 552 Traitement d'images médicales 893 11 Plaquettes et antithrombotiques 13 319 Groupe Perrier Arnaud (Médecine interne générale, de réhabilitation et de gériatrie) 585 432 Lésions cérébrales et attention spatiale 705 505 Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale 843 321 Groupe Pugin Jérôme (Soins intensifs) 587 1313 Médecine de 1er recours 1020 928 Neuropsychologie et neurologie comportementale 951 1409 Neuropsychologie clinique et expérimentale (CENLab) Human brain mapping 44 4 3a0e5118-c38c-45c0-842c-f2e9b8fc0dc3 Article (Published version) Public Human Brain Mapping - 2022 - Voruz .pdf 4768308 application/pdf CC BY-4.0 cbed66b74f9e1872b9af1074d754b850c137c4958873b95f5218b928a02eaa7d d07df7b8-d027-49a7-9338-c40a0f1f4eb0 Supplemental data Public hbm26163-sup-0001-supinfo.docx 1232893 application/vnd.openxmlformats-officedocument.wordprocessingml.document 05310ab4b9de132bc415788aca93ce634fe40d32942011dc5c52ecdda10102f7 openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de psychologie et des sciences de l'éducation / Section de psychologie Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

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Brain functional connectivity alterations associated with neuropsychological performance 6–9 months following SARS‐CoV ‐2 infection	Human brain mapping			2023	282	185

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Adler, Daniel