Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients

Migliorini, Denis; Dutoit Vallotton, Valérie; Allard, Mathilde Camille; Grandjean Hallez, Nicole; Marinari, Eliana; Widmer-Schnuriger, Valérie; Philippin, Géraldine; Corlazzoli, Francesca; Gustave, Robin; Kreutzfeldt, Mario; Blazek, Nathalie; Wasem, Joëlle; Hottinger, Andréas; Koka, Avinash; Momjian, Shahan Marc; Lobrinus, Johannes Alexander; Merkler, Doron; Vargas Gomez, Maria Isabel; Walker, Paul Richard; Patrikidou, Anna; Dietrich, Pierre-Yves

doi:10.1093/neuonc/noz040

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Title		Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients
Authors		Migliorini, Denis Dutoit Vallotton, Valérie Allard, Mathilde Camille Grandjean Hallez, Nicole Marinari, Eliana Widmer-Schnuriger, Valérie Philippin, Géraldine Corlazzoli, Francesca Gustave, Robin Kreutzfeldt, Mario Blazek, Nathalie Wasem, Joëlle Hottinger, Andréas Koka, Avinash Momjian, Shahan Marc Lobrinus, Johannes Alexander Merkler, Doron Vargas Gomez, Maria Isabel Walker, Paul Richard Patrikidou, Anna Dietrich, Pierre-Yves show all authors [1 - 21]
Published in		Neuro-Oncology. 2019
Abstract		Peptide vaccines offer the opportunity to elicit glioma-specific T cells with tumor killing ability. Using antigens eluted from the surface of glioblastoma samples, we designed a phase I/II study to test safety and immunogenicity of the IMA950 multipeptide vaccine adjuvanted with poly-ICLC in HLA-A2 + glioma patients.
Identifiers		DOI: 10.1093/neuonc/noz040 PMID: 30753611
Full text		Article (Accepted version) (1 MB) - Free access Article (Published version) (4.2 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Research groups		La Sclérose en plaques (908) Immunobiologie des tumeurs du cerveau (669) Immunothérapie des cancers (42) Optimisations des techniques avancés en neuroimagerie (985)
Citation (ISO format)		MIGLIORINI, Denis et al. Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients. In: Neuro-Oncology, 2019. doi: 10.1093/neuonc/noz040 https://archive-ouverte.unige.ch/unige:120077