Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients

Article Article scientifique Article Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients eng 2019 author Migliorini Denis 838158 author Dutoit Vallotton Valérie 0000-0002-3469-4237 668630 author Allard Mathilde Camille 870685 author Grandjean Hallez Nicole author Marinari Eliana 841772 author Widmer-Schnuriger Valérie 39000 author Philippin Géraldine 516404 author Corlazzoli Francesca 815588 author Gustave Robin 674503 author Kreutzfeldt Mario 736806 author Blazek Nathalie author Wasem Joëlle author Hottinger Andréas 669644 author Koka Avinash 0000-0002-3911-0528 596271 author Momjian Shahan Marc 84022 author Lobrinus Johannes Alexander 647649 author Merkler Doron 735735 author Vargas Gomez Maria Isabel 503296 author Walker Paul Richard 0000-0001-8999-6366 104900 author Patrikidou Anna 866767 author Dietrich Pierre-Yves 96532 10.1093/neuonc/noz040 30753611 1522-8517 Peptide vaccines offer the opportunity to elicit glioma-specific T cells with tumor killing ability. Using antigens eluted from the surface of glioblastoma samples, we designed a phase I/II study to test safety and immunogenicity of the IMA950 multipeptide vaccine adjuvanted with poly-ICLC in HLA-A2 + glioma patients. Dewey 616 Dewey 616.07 Dewey 616.0757 Dewey 616.8 53 Département de neurosciences fondamentales 21A 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 61 Département des neurosciences cliniques 226 62 Département de radiologie et informatique médicale 227 false 401 Immunobiologie des tumeurs du cerveau 669 27 Immunothérapie des cancers 42 565 La Sclérose en plaques 908 1231 Optimisations des techniques avancés en neuroimagerie 985 Neuro-Oncology 9c037519-0e56-4776-a382-183589fbb6f6 Article (Accepted version) Public Article.pdf 1088974 application/pdf 09161de5-1c75-4040-ac50-ff9cdaf32de8 Article (Published version) Public Migliorini_et_al_2019_NeuroOncol.pdf 4451525 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Title	Published in	Year	Views	Downloads

Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients	Neuro-Oncology	2019	857	844
Exploratory study of the effect of IMA950/poly-ICLC vaccination on response to bevacizumab in relapsing high-grade glioma patients	Cancers	2019	375	247

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Patrikidou, Anna