DM
Merkler, Doron
Affiliation entities
Research groups
Title | Published in | Access level | OA Policy | Year | Views | Downloads | |
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AQP4-specific T cells determine lesion localization in the CNS in a model of NMOSD | Acta neuropathologica communications | 2025 | 5 | 4 | |||
Long survival in a patient with fumarate hydratase mutation-associated glioma | Journal of neuropathology and experimental neurology | 2024 | 24 | 0 | |||
The many faces of myxopapillary ependynomas | American journal of neuroradiology | 2024 | 75 | 0 | |||
BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis | Brain | 2024 | 28 | 9 | |||
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis | Cell | 2024 | 55 | 13 | |||
Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection | Immunity | 2024 | 40 | 8 | |||
The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis | The journal of clinical investigation | 2024 | 33 | 16 | |||
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4 | Nature | 2024 | 116 | 19 | |||
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection | Immunity | 2023 | 111 | 240 | |||
Endothelial cell-derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis | EMBO reports | 2023 | 245 | 97 | |||
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown | Nature communications | 2023 | 129 | 72 | |||
Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS | Acta neuropathologica | 2023 | 197 | 35 | |||
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions | Nature metabolism | 2023 | 81 | 265 | |||
Swiss digital pathology recommendations : results from a Delphi process conducted by the Swiss Digital Pathology Consortium of the Swiss Society of Pathology | Virchows Archiv | 2023 | 81 | 51 | |||
Bridging the gap: immunotherapy in progressive multifocal leukoencephalopathy: a new hope? | Neurology | 2023 | 64 | 28 | |||
Regulator of G-protein signaling 1 critically supports CD8+ TRM cell-mediated intestinal immunity | Frontiers in immunology | 2023 | 118 | 26 | |||
The impact of transsphenoidal surgery on pituitary function in patients with non-functioning macroadenomas | Endocrine | 2023 | 98 | 25 | |||
MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration | Science advances | 2023 | 109 | 36 | |||
Towards a national strategy for digital pathology in Switzerland | Virchows Archiv | 2022 | 185 | 50 | |||
Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity | Genes and immunity | 2022 | 133 | 40 | |||
Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury | Nature communications | 2022 | 115 | 116 | |||
Magnesium sensing via LFA-1 regulates CD8+ T cell effector function | Cell | 2022 | 465 | 2 | |||
Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of GvHD | Blood | 2022 | 393 | 70 | |||
Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS | Science translational medicine | 2022 | 172 | 0 | |||
Clonally Expanded Virus-Specific CD8 T Cells Acquire Diverse Transcriptional Phenotypes During Acute, Chronic, and Latent Infections | Frontiers in immunology | 2022 | 131 | 47 | |||
Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors | Cell reports | 2022 | 117 | 191 | |||
Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV | Brain | 2022 | 131 | 67 | |||
Tissue-resident CD8+ T cells drive compartmentalized and chronic autoimmune damage against CNS neurons | Science translational medicine | 2022 | 110 | 0 | |||
G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis | Science advances | 2022 | 190 | 313 | |||
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates | EMBO journal | 2022 | 242 | 68 | |||
Replication-Deficient Lymphocytic Choriomeningitis Virus-Vectored Vaccine Candidate for the Induction of T Cell Immunity against Mycobacterium tuberculosis | International journal of molecular sciences | 2022 | 217 | 82 | |||
IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis | Science advances | 2022 | 255 | 140 | |||
Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty | Current opinion in immunology | 2022 | 146 | 59 | |||
CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation | Journal of neuroinflammation | 2022 | 171 | 70 | |||
Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis | European Journal of Immunology | 2022 | 141 | 89 | |||
Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation | eLife | 2022 | 256 | 111 | |||
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions | Nature Communications | 2021 | 292 | 163 | |||
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy | Science Immunology | 2021 | 384 | 885 | |||
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation | Nature Neuroscience | 2021 | 374 | 5 | |||
Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice | Proceedings. Biological sciences | 2021 | 218 | 3 | |||
The Janus kinase inhibitor ruxolitinib prevents terminal shock in a mouse model of arenavirus hemorrhagic fever | Microorganisms | 2021 | 252 | 91 | |||
Formation and immunomodulatory function of meningeal B-cell aggregates in progressive CNS autoimmunity | Brain | 2021 | 241 | 131 | |||
Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases | Nature reviews. Neurology. | 2021 | 157 | 0 | |||
Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling | Nature Communications | 2021 | 336 | 306 | |||
Noix de cajou: un incontournable de l'apéro pour guérir la sclérose en plaques ? | Revue médicale suisse | 2021 | 476 | 127 | |||
Neuropathology associated with SARS-CoV-2 infection | The Lancet | 2021 | 399 | 142 | |||
Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation | Journal of Experimental Medicine | 2021 | 204 | 133 | |||
Cold exposure protects from neuroinflammation through immunologic reprogramming | Cell metabolism | 2021 | 465 | 195 | |||
TSPO PET imaging of natalizumab-associated progressive multifocal leukoencephalopathy | Brain | 2021 | 212 | 140 | |||
New advances in immune components mediating viral control in the CNS | Current Opinion in Virology | 2021 | 202 | 122 | |||
Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack | Cell Reports. Medicine | 2021 | 192 | 146 | |||
Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity | PLOS Biology | 2020 | 408 | 174 | |||
Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance | Science Immunology | 2020 | 322 | 2 | |||
Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma | OncoImmunology | 2020 | 346 | 251 | |||
Chronic viral infection promotes efficient germinal center B cell responses | Cell Reports | 2020 | 606 | 290 | |||
Methylation profiling-based diagnosis of radiologically suspected congenital glioma | Brain Tumor Pathology | 2020 | 196 | 1 | |||
Microglial A20 protects the brain from CD8 T-cell-mediated immunopathology | Cell Reports | 2020 | 442 | 295 | |||
Initial viral inoculum determines kinapse-and synapse-like T cell motility in reactive lymph nodes | Frontiers in Immunology | 2019 | 324 | 128 | |||
Expression of the DNA-binding factor TOX promotes the encephalitogenic potential of microbe-induced autoreactive CD8+ T cells | Immunity | 2019 | 447 | 10 | |||
Dendritic cell accumulation in the gut and central nervous system is differentially dependent on α4 integrins | Journal of Immunology | 2019 | 378 | 1 | |||
Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients | Neuro-Oncology | 2019 | 763 | 384 | |||
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection | Nature | 2019 | 439 | 0 | |||
CD8+ T cells induce cachexia during chronic viral infection | Nature Immunology | 2019 | 487 | 0 | |||
Melanocytic colonization of choroid plexus papilloma: a previously undocumented source of pigment storage in the plexogenic epithelium | Clinical Neuropathology | 2019 | 348 | 242 | |||
In vivo function of the lipid raft protein flotillin-1 during CD8+ T cell-mediated host surveillance | Journal of Immunology | 2019 | 277 | 0 | |||
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity | Nature Neuroscience | 2019 | 391 | 0 | |||
Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice | Science Translational Medicine | 2019 | 535 | 44 | |||
Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patient | Multiple Sclerosis and Related Disorders | 2019 | 400 | 2 | |||
Bassoon proteinopathy drives neurodegeneration in multiple sclerosis | Nature Neuroscience | 2019 | 519 | 4 | |||
Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping | Cell | 2018 | 784 | 19 | |||
Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report | Frontiers in Neurology | 2018 | 519 | 4 | |||
Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements | Cell Metabolism | 2018 | 566 | 356 | |||
Expression of the DNA-binding factor TOX promotes the encephalitogenic potential of microbe-induced autoreactive CD8+ T cells | Immunity | 2018 | 971 | 19 | |||
Enhanced Voluntary Exercise Improves Functional Recovery following Spinal Cord Injury by Impacting the Local Neuroglial Injury Response and Supporting the Rewiring of Supraspinal Circuits | Journal of Neurotrauma | 2018 | 427 | 2 | |||
Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner | Immunity | 2018 | 1,008 | 2 | |||
The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells | Journal of Experimental Medicine | 2018 | 455 | 0 | |||
The Swiss Multiple Sclerosis Registry (SMSR): study protocol of a participatory, nationwide registry to promote epidemiological and patient-centered MS research | BMC Neurology | 2018 | 385 | 272 | |||
Resident-memory T cells in tissue-restricted immune responses: for better or worse? | Frontiers in Immunology | 2018 | 447 | 259 | |||
High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease | Immunity | 2018 | 474 | 4 | |||
Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity | Nature Immunology | 2018 | 369 | 2 | |||
Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients | Journal of Neuroinflammation | 2017 | 521 | 195 | |||
STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells | Nature Communications | 2017 | 583 | 311 | |||
Germline PMS2 and somatic POLEexo mutations cause hypermutability of the leading DNA strand in Biallelic Mismatch Repair Deficiency syndrome brain tumors | The Journal of Pathology | 2017 | 618 | 2 | |||
Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever | Cell Host & Microbe | 2017 | 550 | 1 | |||
The Immune System Bridges the Gut Microbiota with Systemic Energy Homeostasis: Focus on TLRs, Mucosal Barrier, and SCFAs | Frontiers in Immunology | 2017 | 631 | 260 | |||
Clival chordoma: a single-centre outcome analysis | Acta Neurochirurgica | 2017 | 492 | 4 | |||
Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy | Nature Communications | 2017 | 587 | 202 | |||
Interferon-driven deletion of antiviral B cells at the onset of chronic infection | Science immunology | 2016 | 406 | 60 | |||
Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis | Brain | 2016 | 604 | 6 | |||
Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model | Nature communications | 2016 | 425 | 225 | |||
pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation | Journal of autoimmunity | 2016 | 643 | 271 | |||
Medulloblastoma in children and adults: one distinct disease entity? | Bulletin suisse du cancer | 2016 | 459 | 48 | |||
TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells | GLIA | 2016 | 503 | 0 | |||
Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses | Cell reports | 2016 | 551 | 198 | |||
pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion | The Journal of experimental medicine | 2016 | 463 | 0 | |||
B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation | Scientific reports | 2016 | 582 | 233 | |||
Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection | The Journal of experimental medicine | 2016 | 633 | 6 | |||
In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology | Annals of neurology | 2016 | 453 | 1 | |||
Oxysterols regulate encephalitogenic CD4+ T cell trafficking during central nervous system autoimmunity | Journal of autoimmunity | 2015 | 779 | 15 | |||
Recurrent multiple CNS hemangioblastomas with VHL disease treated with pazopanib: a case report and literature review | CNS oncology | 2015 | 471 | 0 | |||
USP18 lack in microglia causes destructive interferonopathy of the mouse brain | EMBO journal | 2015 | 589 | 0 | |||
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection | Nature immunology | 2015 | 654 | 2 | |||
Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage | Immunity | 2015 | 562 | 0 | |||
IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling | The Journal of immunology | 2015 | 600 | 0 | |||
Neuropathological Techniques to Investigate CNS Pathology in Experimental Autoimmune Encephalomyelitis (EAE) | Methods in molecular biology | 2014 | 628 | 0 | |||
TLR7 signaling exacerbates CNS autoimmunity through downregulation of Foxp3(+) Treg cells | European Journal of Immunology | 2014 | 628 | 1 | |||
Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells | The Journal of immunology | 2014 | 663 | 3 | |||
Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis | CNS drugs | 2014 | 576 | 5 | |||
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue | Cell | 2014 | 567 | 0 | |||
Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination | Acta neuropathologica | 2014 | 655 | 2 | |||
Pervasive Axonal Transport Deficits in Multiple Sclerosis Models | Neuron | 2014 | 496 | 0 | |||
Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis | Journal of cerebral blood flow and metabolism | 2013 | 573 | 1 | |||
Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions | Brain pathology | 2013 | 743 | 0 | |||
Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss | The Journal of experimental medicine | 2013 | 580 | 3 | |||
Intracranial hypertension following highly active antiretroviral therapy interruption in an HIV-infected woman: case report and review of the literature | AIDS | 2013 | 604 | 0 | |||
Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers | PloS one | 2013 | 551 | 475 | |||
Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior | Behavioural brain research | 2012 | 571 | 0 | |||
Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia | GLIA | 2012 | 659 | 0 | |||
The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses | Science | 2012 | 665 | 0 | |||
IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis | Journal of neuroinflammation | 2012 | 669 | 311 | |||
Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis | Annals of neurology | 2012 | 605 | 2 | |||
Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection | The Journal of experimental medicine | 2012 | 618 | 0 | |||
Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency | The American journal of pathology | 2012 | 591 | 0 | |||
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis | Nature medicine | 2012 | 714 | 2 | |||
IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system | Brain | 2011 | 593 | 1 | |||
Targeted ablation of oligodendrocytes triggers axonal damage | PloS one | 2011 | 629 | 597 | |||
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis | Nature medicine | 2011 | 507 | 0 | |||
Impact of sphingosine 1-phosphate modulation on immune outcomes | Neurology | 2011 | 606 | 1 | |||
T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner | Brain | 2010 | 503 | 0 | |||
Oxidized ATP inhibits T-cell-mediated autoimmunity | European Journal of Immunology | 2010 | 605 | 0 | |||
T cell-dependence of Lassa fever pathogenesis | PLOS pathogens | 2010 | 944 | 1,086 | |||
Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant | Experimental neurology | 2009 | 632 | 0 | |||
Impaired antibody response causes persistence of prototypic T cell-contained virus | PLoS biology | 2009 | 685 | 679 | |||
Propagation of spreading depression inversely correlates with cortical myelin content | Annals of neurology | 2009 | 577 | 0 | |||
Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system | Immunity | 2008 | 525 | 0 | |||
Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo | The Journal of neuroscience | 2008 | 614 | 0 | |||
Aggravation of viral hepatitis by platelet-derived serotonin | Nature medicine | 2008 | 655 | 0 |