DM
Merkler, Doron
| Title | Published in | Access level | OA Policy | Year | Views | Downloads | |
|---|---|---|---|---|---|---|---|
| Lack of junctional adhesion molecule (JAM)-B traps CD8 T cells in CNS border zones and ameliorates autoimmune neuroinflammation | Acta neuropathologica communications |  | 2025 | 34 | 28 | ||
| Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity | The Journal of experimental medicine | | 2025 | 38 | 52 | ||
| AQP4-specific T cells determine lesion localization in the CNS in a model of NMOSD | Acta neuropathologica communications | | 2025 | 54 | 59 | ||
| The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis | Cell | | 2025 | 55 | 12 | ||
| Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens | Acta neuropathologica | | 2025 | 26 | 11 | ||
| Long survival in a patient with fumarate hydratase mutation-associated glioma | Journal of neuropathology and experimental neurology |  | 2024 | 52 | 0 | ||
| The many faces of myxopapillary ependynomas | American journal of neuroradiology | | 2024 | 101 | 0 | ||
| BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis | Brain | | 2024 | 62 | 19 | ||
| STING orchestrates the neuronal inflammatory stress response in multiple sclerosis | Cell | | 2024 | 129 | 98 | ||
| Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection | Immunity | | 2024 | 153 | 44 | ||
| The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis | The journal of clinical investigation | | 2024 | 65 | 35 | ||
| B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4 | Nature | | 2024 | 188 | 50 | ||
| The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection | Immunity | | 2023 | 159 | 302 | ||
| Endothelial cell-derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis | EMBO reports | | 2023 | 282 | 173 | ||
| Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown | Nature communications | | 2023 | 182 | 116 | ||
| Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS | Acta neuropathologica | | 2023 | 248 | 60 | ||
| Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions | Nature metabolism | | 2023 | 138 | 318 | ||
| Swiss digital pathology recommendations : results from a Delphi process conducted by the Swiss Digital Pathology Consortium of the Swiss Society of Pathology | Virchows Archiv | | 2023 | 157 | 177 | ||
| Bridging the gap: immunotherapy in progressive multifocal leukoencephalopathy: a new hope? | Neurology | | 2023 | 107 | 57 | ||
| Regulator of G-protein signaling 1 critically supports CD8+ TRM cell-mediated intestinal immunity | Frontiers in immunology | | 2023 | 173 | 47 | ||
| The impact of transsphenoidal surgery on pituitary function in patients with non-functioning macroadenomas | Endocrine | | 2023 | 134 | 144 | ||
| MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration | Science advances | | 2023 | 167 | 112 | ||
| Towards a national strategy for digital pathology in Switzerland | Virchows Archiv | | 2022 | 234 | 60 | ||
| Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity | Genes and immunity | | 2022 | 197 | 71 | ||
| Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury | Nature communications | | 2022 | 151 | 128 | ||
| Magnesium sensing via LFA-1 regulates CD8+ T cell effector function | Cell | | 2022 | 529 | 2 | ||
| Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of GvHD | Blood | | 2022 | 493 | 113 | ||
| Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS | Science translational medicine | | 2022 | 221 | 0 | ||
| Clonally Expanded Virus-Specific CD8 T Cells Acquire Diverse Transcriptional Phenotypes During Acute, Chronic, and Latent Infections | Frontiers in immunology | | 2022 | 179 | 60 | ||
| Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors | Cell reports | | 2022 | 162 | 276 | ||
| Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV | Brain | | 2022 | 167 | 113 | ||
| Tissue-resident CD8+ T cells drive compartmentalized and chronic autoimmune damage against CNS neurons | Science translational medicine | | 2022 | 160 | 0 | ||
| G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis | Science advances | | 2022 | 237 | 404 | ||
| Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates | EMBO journal | | 2022 | 302 | 116 | ||
| Replication-Deficient Lymphocytic Choriomeningitis Virus-Vectored Vaccine Candidate for the Induction of T Cell Immunity against Mycobacterium tuberculosis | International journal of molecular sciences | | 2022 | 268 | 138 | ||
| IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis | Science advances | | 2022 | 363 | 170 | ||
| Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty | Current opinion in immunology | | 2022 | 163 | 194 | ||
| CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation | Journal of neuroinflammation | | 2022 | 229 | 99 | ||
| Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis | European Journal of Immunology | | 2022 | 189 | 124 | ||
| Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation | eLife | | 2022 | 289 | 136 | ||
| PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions | Nature Communications | | 2021 | 355 | 205 | ||
| Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy | Science Immunology | | 2021 | 458 | 940 | ||
| Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation | Nature Neuroscience | | 2021 | 416 | 5 | ||
| Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice | Proceedings. Biological sciences | | 2021 | 261 | 3 | ||
| The Janus kinase inhibitor ruxolitinib prevents terminal shock in a mouse model of arenavirus hemorrhagic fever | Microorganisms | | 2021 | 299 | 128 | ||
| Formation and immunomodulatory function of meningeal B-cell aggregates in progressive CNS autoimmunity | Brain | | 2021 | 286 | 189 | ||
| Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases | Nature reviews. Neurology. | | 2021 | 198 | 0 | ||
| Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling | Nature Communications | | 2021 | 374 | 323 | ||
| Noix de cajou: un incontournable de l'apéro pour guérir la sclérose en plaques ? | Revue médicale suisse | | 2021 | 540 | 268 | ||
| Neuropathology associated with SARS-CoV-2 infection | The Lancet | | 2021 | 438 | 177 | ||
| Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation | Journal of Experimental Medicine | | 2021 | 255 | 221 | ||
| Cold exposure protects from neuroinflammation through immunologic reprogramming | Cell metabolism | | 2021 | 612 | 279 | ||
| TSPO PET imaging of natalizumab-associated progressive multifocal leukoencephalopathy | Brain | | 2021 | 241 | 206 | ||
| New advances in immune components mediating viral control in the CNS | Current Opinion in Virology | | 2021 | 238 | 194 | ||
| Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack | Cell Reports. Medicine | | 2021 | 239 | 184 | ||
| Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity | PLOS Biology | | 2020 | 436 | 177 | ||
| Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance | Science Immunology | | 2020 | 373 | 2 | ||
| Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma | OncoImmunology | | 2020 | 456 | 276 | ||
| Chronic viral infection promotes efficient germinal center B cell responses | Cell Reports | | 2020 | 694 | 340 | ||
| Methylation profiling-based diagnosis of radiologically suspected congenital glioma | Brain Tumor Pathology | | 2020 | 232 | 1 | ||
| Microglial A20 protects the brain from CD8 T-cell-mediated immunopathology | Cell Reports | | 2020 | 497 | 314 | ||
| Initial viral inoculum determines kinapse-and synapse-like T cell motility in reactive lymph nodes | Frontiers in Immunology | | 2019 | 365 | 140 | ||
| Expression of the DNA-binding factor TOX promotes the encephalitogenic potential of microbe-induced autoreactive CD8+ T cells | Immunity | 2019 | 487 | 10 | |||
| Dendritic cell accumulation in the gut and central nervous system is differentially dependent on α4 integrins | Journal of Immunology | | 2019 | 411 | 1 | ||
| Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients | Neuro-Oncology | | 2019 | 839 | 499 | ||
| TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection | Nature | | 2019 | 564 | 0 | ||
| CD8+ T cells induce cachexia during chronic viral infection | Nature Immunology | | 2019 | 531 | 0 | ||
| Melanocytic colonization of choroid plexus papilloma: a previously undocumented source of pigment storage in the plexogenic epithelium | Clinical Neuropathology | | 2019 | 397 | 324 | ||
| In vivo function of the lipid raft protein flotillin-1 during CD8+ T cell-mediated host surveillance | Journal of Immunology | | 2019 | 313 | 0 | ||
| Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity | Nature Neuroscience | | 2019 | 478 | 0 | ||
| Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice | Science Translational Medicine | | 2019 | 620 | 86 | ||
| Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patient | Multiple Sclerosis and Related Disorders | | 2019 | 432 | 2 | ||
| Bassoon proteinopathy drives neurodegeneration in multiple sclerosis | Nature Neuroscience | | 2019 | 565 | 4 | ||
| Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping | Cell | | 2018 | 831 | 19 | ||
| Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report | Frontiers in Neurology | | 2018 | 542 | 4 | ||
| Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements | Cell Metabolism | | 2018 | 607 | 371 | ||
| Expression of the DNA-binding factor TOX promotes the encephalitogenic potential of microbe-induced autoreactive CD8+ T cells | Immunity | | 2018 | 1,018 | 19 | ||
| Enhanced Voluntary Exercise Improves Functional Recovery following Spinal Cord Injury by Impacting the Local Neuroglial Injury Response and Supporting the Rewiring of Supraspinal Circuits | Journal of Neurotrauma | | 2018 | 469 | 2 | ||
| Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner | Immunity | | 2018 | 1,053 | 2 | ||
| The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells | Journal of Experimental Medicine | | 2018 | 498 | 0 | ||
| The Swiss Multiple Sclerosis Registry (SMSR): study protocol of a participatory, nationwide registry to promote epidemiological and patient-centered MS research | BMC Neurology | | 2018 | 426 | 325 | ||
| Resident-memory T cells in tissue-restricted immune responses: for better or worse? | Frontiers in Immunology | | 2018 | 483 | 320 | ||
| High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease | Immunity | | 2018 | 506 | 4 | ||
| Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity | Nature Immunology | | 2018 | 412 | 2 | ||
| Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients | Journal of Neuroinflammation | | 2017 | 582 | 216 | ||
| STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells | Nature Communications | | 2017 | 642 | 329 | ||
| Germline PMS2 and somatic POLEexo mutations cause hypermutability of the leading DNA strand in Biallelic Mismatch Repair Deficiency syndrome brain tumors | The Journal of Pathology | | 2017 | 674 | 2 | ||
| Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever | Cell Host & Microbe | | 2017 | 588 | 1 | ||
| The Immune System Bridges the Gut Microbiota with Systemic Energy Homeostasis: Focus on TLRs, Mucosal Barrier, and SCFAs | Frontiers in Immunology | | 2017 | 671 | 324 | ||
| Clival chordoma: a single-centre outcome analysis | Acta Neurochirurgica | | 2017 | 524 | 4 | ||
| Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy | Nature Communications | | 2017 | 649 | 247 | ||
| Interferon-driven deletion of antiviral B cells at the onset of chronic infection | Science immunology | | 2016 | 459 | 72 | ||
| Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis | Brain | | 2016 | 654 | 6 | ||
| Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model | Nature communications | | 2016 | 462 | 248 | ||
| pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation | Journal of autoimmunity | | 2016 | 719 | 305 | ||
| Medulloblastoma in children and adults: one distinct disease entity? | Bulletin suisse du cancer | | 2016 | 503 | 59 | ||
| TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells | GLIA | | 2016 | 554 | 0 | ||
| Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses | Cell reports | | 2016 | 595 | 225 | ||
| pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion | The Journal of experimental medicine | | 2016 | 497 | 0 | ||
| B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation | Scientific reports | | 2016 | 622 | 251 | ||
| Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection | The Journal of experimental medicine | | 2016 | 665 | 6 | ||
| In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology | Annals of neurology | | 2016 | 493 | 1 | ||
| Oxysterols regulate encephalitogenic CD4+ T cell trafficking during central nervous system autoimmunity | Journal of autoimmunity | | 2015 | 813 | 15 | ||
| Recurrent multiple CNS hemangioblastomas with VHL disease treated with pazopanib: a case report and literature review | CNS oncology | 2015 | 504 | 0 | |||
| USP18 lack in microglia causes destructive interferonopathy of the mouse brain | EMBO journal | | 2015 | 635 | 0 | ||
| The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection | Nature immunology | | 2015 | 703 | 2 | ||
| Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage | Immunity | | 2015 | 613 | 0 | ||
| IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling | The Journal of immunology | | 2015 | 639 | 0 | ||
| Neuropathological Techniques to Investigate CNS Pathology in Experimental Autoimmune Encephalomyelitis (EAE) | Methods in molecular biology | 2014 | 682 | 0 | |||
| TLR7 signaling exacerbates CNS autoimmunity through downregulation of Foxp3(+) Treg cells | European Journal of Immunology | | 2014 | 664 | 1 | ||
| Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells | The Journal of immunology | | 2014 | 692 | 3 | ||
| Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis | CNS drugs | | 2014 | 618 | 5 | ||
| Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue | Cell | | 2014 | 626 | 0 | ||
| Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination | Acta neuropathologica | | 2014 | 690 | 2 | ||
| Pervasive Axonal Transport Deficits in Multiple Sclerosis Models | Neuron | | 2014 | 547 | 0 | ||
| Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis | Journal of cerebral blood flow and metabolism | | 2013 | 613 | 1 | ||
| Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions | Brain pathology | | 2013 | 770 | 0 | ||
| Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss | The Journal of experimental medicine | | 2013 | 625 | 3 | ||
| Intracranial hypertension following highly active antiretroviral therapy interruption in an HIV-infected woman: case report and review of the literature | AIDS | | 2013 | 633 | 0 | ||
| Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers | PloS one | | 2013 | 593 | 491 | ||
| Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior | Behavioural brain research | | 2012 | 651 | 0 | ||
| Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia | GLIA | | 2012 | 694 | 0 | ||
| The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses | Science | | 2012 | 722 | 0 | ||
| IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis | Journal of neuroinflammation | | 2012 | 723 | 327 | ||
| Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis | Annals of neurology | | 2012 | 640 | 2 | ||
| Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection | The Journal of experimental medicine | | 2012 | 665 | 0 | ||
| Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency | The American journal of pathology | | 2012 | 623 | 0 | ||
| TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis | Nature medicine | | 2012 | 757 | 2 | ||
| IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system | Brain | | 2011 | 635 | 1 | ||
| Targeted ablation of oligodendrocytes triggers axonal damage | PloS one | | 2011 | 681 | 613 | ||
| A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis | Nature medicine | | 2011 | 558 | 0 | ||
| Impact of sphingosine 1-phosphate modulation on immune outcomes | Neurology | | 2011 | 639 | 1 | ||
| T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner | Brain | | 2010 | 560 | 0 | ||
| Oxidized ATP inhibits T-cell-mediated autoimmunity | European Journal of Immunology | | 2010 | 646 | 0 | ||
| T cell-dependence of Lassa fever pathogenesis | PLOS pathogens | | 2010 | 1,005 | 1,110 | ||
| Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant | Experimental neurology | | 2009 | 687 | 0 | ||
| Impaired antibody response causes persistence of prototypic T cell-contained virus | PLoS biology | | 2009 | 751 | 723 | ||
| Propagation of spreading depression inversely correlates with cortical myelin content | Annals of neurology | | 2009 | 619 | 0 | ||
| Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system | Immunity | | 2008 | 570 | 0 | ||
| Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo | The Journal of neuroscience | | 2008 | 666 | 0 | ||
| Aggravation of viral hepatitis by platelet-derived serotonin | Nature medicine | | 2008 | 705 | 0 |
