DM
Merkler, Doron
| Title | Published in | Access level | OA Policy | Year | Views | Downloads | |
|---|---|---|---|---|---|---|---|
| Dysregulation of the endosomal sorting complex III is linked to neurodegeneration in progressive multiple sclerosis | Brain pathology |  | 2026 | 14 | 16 | ||
| Lack of junctional adhesion molecule (JAM)-B traps CD8 T cells in CNS border zones and ameliorates autoimmune neuroinflammation | Acta neuropathologica communications | | 2025 | 39 | 65 | ||
| Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity | The Journal of experimental medicine | | 2025 | 43 | 159 | ||
| AQP4-specific T cells determine lesion localization in the CNS in a model of NMOSD | Acta neuropathologica communications | | 2025 | 60 | 144 | ||
| Neuron-reactive KIR+CD8+ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis | Nature communications | | 2025 | 14 | 17 | ||
| The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis | Cell | | 2025 | 66 | 17 | ||
| Orf virus-based vectors induce potent germinal center B cell, Tfh cell, and CD8+ T cell responses | Molecular therapy | | 2025 | 6 | 12 | ||
| mRNA prime-boost vaccination promotes clonal continuity in germinal center reactions and broadens SARS-CoV-2 variant coverage | Molecular therapy | | 2025 | 9 | 8 | ||
| Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens | Acta neuropathologica | | 2025 | 29 | 29 | ||
| SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis | Science translational medicine | | 2025 | 8 | 49 | ||
| Long survival in a patient with fumarate hydratase mutation-associated glioma | Journal of neuropathology and experimental neurology |  | 2024 | 56 | 0 | ||
| The many faces of myxopapillary ependynomas | American journal of neuroradiology | | 2024 | 107 | 0 | ||
| BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis | Brain | | 2024 | 64 | 30 | ||
| STING orchestrates the neuronal inflammatory stress response in multiple sclerosis | Cell | | 2024 | 132 | 326 | ||
| Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection | Immunity | | 2024 | 155 | 60 | ||
| The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis | The journal of clinical investigation | | 2024 | 68 | 42 | ||
| B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4 | Nature | | 2024 | 189 | 104 | ||
| The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection | Immunity | | 2023 | 161 | 333 | ||
| Endothelial cell-derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis | EMBO reports | | 2023 | 289 | 265 | ||
| Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown | Nature communications | | 2023 | 185 | 197 | ||
| Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS | Acta neuropathologica | | 2023 | 252 | 106 | ||
| Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions | Nature metabolism | | 2023 | 141 | 350 | ||
| Swiss digital pathology recommendations : results from a Delphi process conducted by the Swiss Digital Pathology Consortium of the Swiss Society of Pathology | Virchows Archiv | | 2023 | 159 | 266 | ||
| Bridging the gap: immunotherapy in progressive multifocal leukoencephalopathy: a new hope? | Neurology | | 2023 | 109 | 81 | ||
| Regulator of G-protein signaling 1 critically supports CD8+ TRM cell-mediated intestinal immunity | Frontiers in immunology | | 2023 | 175 | 86 | ||
| The impact of transsphenoidal surgery on pituitary function in patients with non-functioning macroadenomas | Endocrine | | 2023 | 145 | 251 | ||
| MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration | Science advances | | 2023 | 172 | 175 | ||
| Towards a national strategy for digital pathology in Switzerland | Virchows Archiv | | 2022 | 240 | 82 | ||
| Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity | Genes and immunity | | 2022 | 199 | 116 | ||
| Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury | Nature communications | | 2022 | 155 | 161 | ||
| Magnesium sensing via LFA-1 regulates CD8+ T cell effector function | Cell | | 2022 | 535 | 2 | ||
| Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of GvHD | Blood | | 2022 | 501 | 137 | ||
| Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS | Science translational medicine | | 2022 | 226 | 0 | ||
| Clonally Expanded Virus-Specific CD8 T Cells Acquire Diverse Transcriptional Phenotypes During Acute, Chronic, and Latent Infections | Frontiers in immunology | | 2022 | 182 | 67 | ||
| Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors | Cell reports | | 2022 | 167 | 337 | ||
| Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV | Brain | | 2022 | 170 | 139 | ||
| Tissue-resident CD8+ T cells drive compartmentalized and chronic autoimmune damage against CNS neurons | Science translational medicine | | 2022 | 162 | 0 | ||
| G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis | Science advances | | 2022 | 239 | 467 | ||
| Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates | EMBO journal | | 2022 | 308 | 198 | ||
| Replication-Deficient Lymphocytic Choriomeningitis Virus-Vectored Vaccine Candidate for the Induction of T Cell Immunity against Mycobacterium tuberculosis | International journal of molecular sciences | | 2022 | 269 | 161 | ||
| IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis | Science advances | | 2022 | 367 | 192 | ||
| Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty | Current opinion in immunology | | 2022 | 165 | 317 | ||
| CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation | Journal of neuroinflammation | | 2022 | 234 | 107 | ||
| Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis | European Journal of Immunology | | 2022 | 190 | 150 | ||
| Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation | eLife | | 2022 | 291 | 141 | ||
| PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions | Nature Communications | | 2021 | 356 | 248 | ||
| Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy | Science Immunology | | 2021 | 462 | 959 | ||
| Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation | Nature Neuroscience | | 2021 | 419 | 5 | ||
| Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice | Proceedings. Biological sciences | | 2021 | 263 | 3 | ||
| The Janus kinase inhibitor ruxolitinib prevents terminal shock in a mouse model of arenavirus hemorrhagic fever | Microorganisms | | 2021 | 301 | 147 | ||
| Formation and immunomodulatory function of meningeal B-cell aggregates in progressive CNS autoimmunity | Brain | | 2021 | 287 | 233 | ||
| Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases | Nature reviews. Neurology. | | 2021 | 200 | 0 | ||
| Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling | Nature Communications | | 2021 | 377 | 329 | ||
| Noix de cajou: un incontournable de l'apéro pour guérir la sclérose en plaques ? | Revue médicale suisse | | 2021 | 543 | 303 | ||
| Neuropathology associated with SARS-CoV-2 infection | The Lancet | | 2021 | 440 | 195 | ||
| Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation | Journal of Experimental Medicine | | 2021 | 256 | 375 | ||
| Cold exposure protects from neuroinflammation through immunologic reprogramming | Cell metabolism | | 2021 | 620 | 358 | ||
| TSPO PET imaging of natalizumab-associated progressive multifocal leukoencephalopathy | Brain | | 2021 | 243 | 245 | ||
| New advances in immune components mediating viral control in the CNS | Current Opinion in Virology | | 2021 | 240 | 237 | ||
| Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack | Cell Reports. Medicine | | 2021 | 240 | 193 | ||
| Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity | PLOS Biology | | 2020 | 438 | 180 | ||
| Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance | Science Immunology | | 2020 | 374 | 2 | ||
| Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma | OncoImmunology | | 2020 | 458 | 297 | ||
| Chronic viral infection promotes efficient germinal center B cell responses | Cell Reports | | 2020 | 696 | 356 | ||
| Methylation profiling-based diagnosis of radiologically suspected congenital glioma | Brain Tumor Pathology | | 2020 | 235 | 1 | ||
| Microglial A20 protects the brain from CD8 T-cell-mediated immunopathology | Cell Reports | | 2020 | 498 | 321 | ||
| Initial viral inoculum determines kinapse-and synapse-like T cell motility in reactive lymph nodes | Frontiers in Immunology | | 2019 | 371 | 147 | ||
| Expression of the DNA-binding factor TOX promotes the encephalitogenic potential of microbe-induced autoreactive CD8+ T cells | Immunity | 2019 | 491 | 10 | |||
| Dendritic cell accumulation in the gut and central nervous system is differentially dependent on α4 integrins | Journal of Immunology | | 2019 | 413 | 1 | ||
| Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients | Neuro-Oncology | | 2019 | 848 | 586 | ||
| TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection | Nature | | 2019 | 566 | 0 | ||
| CD8+ T cells induce cachexia during chronic viral infection | Nature Immunology | | 2019 | 536 | 0 | ||
| Melanocytic colonization of choroid plexus papilloma: a previously undocumented source of pigment storage in the plexogenic epithelium | Clinical Neuropathology | | 2019 | 401 | 348 | ||
| In vivo function of the lipid raft protein flotillin-1 during CD8+ T cell-mediated host surveillance | Journal of Immunology | | 2019 | 315 | 0 | ||
| Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity | Nature Neuroscience | | 2019 | 492 | 0 | ||
| Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice | Science Translational Medicine | | 2019 | 622 | 90 | ||
| Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patient | Multiple Sclerosis and Related Disorders | | 2019 | 434 | 2 | ||
| Bassoon proteinopathy drives neurodegeneration in multiple sclerosis | Nature Neuroscience | | 2019 | 569 | 4 | ||
| Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping | Cell | | 2018 | 832 | 19 | ||
| Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report | Frontiers in Neurology | | 2018 | 547 | 4 | ||
| Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements | Cell Metabolism | | 2018 | 610 | 400 | ||
| Expression of the DNA-binding factor TOX promotes the encephalitogenic potential of microbe-induced autoreactive CD8+ T cells | Immunity | | 2018 | 1,019 | 19 | ||
| Enhanced Voluntary Exercise Improves Functional Recovery following Spinal Cord Injury by Impacting the Local Neuroglial Injury Response and Supporting the Rewiring of Supraspinal Circuits | Journal of Neurotrauma | | 2018 | 471 | 2 | ||
| Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner | Immunity | | 2018 | 1,054 | 2 | ||
| The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells | Journal of Experimental Medicine | | 2018 | 501 | 0 | ||
| The Swiss Multiple Sclerosis Registry (SMSR): study protocol of a participatory, nationwide registry to promote epidemiological and patient-centered MS research | BMC Neurology | | 2018 | 428 | 385 | ||
| Resident-memory T cells in tissue-restricted immune responses: for better or worse? | Frontiers in Immunology | | 2018 | 487 | 367 | ||
| High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease | Immunity | | 2018 | 510 | 4 | ||
| Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity | Nature Immunology | | 2018 | 413 | 2 | ||
| Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients | Journal of Neuroinflammation | | 2017 | 583 | 226 | ||
| STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells | Nature Communications | | 2017 | 644 | 372 | ||
| Germline PMS2 and somatic POLEexo mutations cause hypermutability of the leading DNA strand in Biallelic Mismatch Repair Deficiency syndrome brain tumors | The Journal of Pathology | | 2017 | 677 | 2 | ||
| Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever | Cell Host & Microbe | | 2017 | 591 | 1 | ||
| The Immune System Bridges the Gut Microbiota with Systemic Energy Homeostasis: Focus on TLRs, Mucosal Barrier, and SCFAs | Frontiers in Immunology | | 2017 | 674 | 422 | ||
| Clival chordoma: a single-centre outcome analysis | Acta Neurochirurgica | | 2017 | 527 | 4 | ||
| Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy | Nature Communications | | 2017 | 652 | 288 | ||
| Interferon-driven deletion of antiviral B cells at the onset of chronic infection | Science immunology | | 2016 | 461 | 82 | ||
| Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis | Brain | | 2016 | 657 | 6 | ||
| Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model | Nature communications | | 2016 | 465 | 266 | ||
| pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation | Journal of autoimmunity | | 2016 | 725 | 315 | ||
| Medulloblastoma in children and adults: one distinct disease entity? | Bulletin suisse du cancer | | 2016 | 506 | 67 | ||
| TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells | GLIA | | 2016 | 556 | 0 | ||
| Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses | Cell reports | | 2016 | 598 | 277 | ||
| pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion | The Journal of experimental medicine | | 2016 | 500 | 0 | ||
| B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation | Scientific reports | | 2016 | 625 | 267 | ||
| Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection | The Journal of experimental medicine | | 2016 | 667 | 6 | ||
| In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology | Annals of neurology | | 2016 | 494 | 1 | ||
| Oxysterols regulate encephalitogenic CD4+ T cell trafficking during central nervous system autoimmunity | Journal of autoimmunity | | 2015 | 815 | 15 | ||
| Recurrent multiple CNS hemangioblastomas with VHL disease treated with pazopanib: a case report and literature review | CNS oncology | 2015 | 509 | 0 | |||
| USP18 lack in microglia causes destructive interferonopathy of the mouse brain | EMBO journal | | 2015 | 637 | 0 | ||
| The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection | Nature immunology | | 2015 | 710 | 2 | ||
| Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage | Immunity | | 2015 | 614 | 0 | ||
| IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling | The Journal of immunology | | 2015 | 641 | 0 | ||
| Neuropathological Techniques to Investigate CNS Pathology in Experimental Autoimmune Encephalomyelitis (EAE) | Methods in molecular biology | 2014 | 687 | 0 | |||
| TLR7 signaling exacerbates CNS autoimmunity through downregulation of Foxp3(+) Treg cells | European Journal of Immunology | | 2014 | 670 | 1 | ||
| Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells | The Journal of immunology | | 2014 | 694 | 3 | ||
| Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis | CNS drugs | | 2014 | 622 | 5 | ||
| Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue | Cell | | 2014 | 630 | 0 | ||
| Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination | Acta neuropathologica | | 2014 | 693 | 2 | ||
| Pervasive Axonal Transport Deficits in Multiple Sclerosis Models | Neuron | | 2014 | 550 | 0 | ||
| Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis | Journal of cerebral blood flow and metabolism | | 2013 | 618 | 1 | ||
| Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions | Brain pathology | | 2013 | 774 | 0 | ||
| Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss | The Journal of experimental medicine | | 2013 | 629 | 3 | ||
| Intracranial hypertension following highly active antiretroviral therapy interruption in an HIV-infected woman: case report and review of the literature | AIDS | | 2013 | 635 | 0 | ||
| Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers | PloS one | | 2013 | 596 | 516 | ||
| Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior | Behavioural brain research | | 2012 | 654 | 0 | ||
| Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia | GLIA | | 2012 | 699 | 0 | ||
| The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses | Science | | 2012 | 725 | 0 | ||
| IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis | Journal of neuroinflammation | | 2012 | 726 | 337 | ||
| Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis | Annals of neurology | | 2012 | 643 | 2 | ||
| Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection | The Journal of experimental medicine | | 2012 | 667 | 0 | ||
| Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency | The American journal of pathology | | 2012 | 625 | 0 | ||
| TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis | Nature medicine | | 2012 | 760 | 2 | ||
| IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system | Brain | | 2011 | 638 | 1 | ||
| Targeted ablation of oligodendrocytes triggers axonal damage | PloS one | | 2011 | 684 | 622 | ||
| A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis | Nature medicine | | 2011 | 563 | 0 | ||
| Impact of sphingosine 1-phosphate modulation on immune outcomes | Neurology | | 2011 | 645 | 1 | ||
| T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner | Brain | | 2010 | 563 | 0 | ||
| Oxidized ATP inhibits T-cell-mediated autoimmunity | European Journal of Immunology | | 2010 | 649 | 0 | ||
| T cell-dependence of Lassa fever pathogenesis | PLOS pathogens | | 2010 | 1,038 | 1,125 | ||
| Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant | Experimental neurology | | 2009 | 693 | 0 | ||
| Impaired antibody response causes persistence of prototypic T cell-contained virus | PLoS biology | | 2009 | 754 | 750 | ||
| Propagation of spreading depression inversely correlates with cortical myelin content | Annals of neurology | | 2009 | 625 | 0 | ||
| Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system | Immunity | | 2008 | 575 | 0 | ||
| Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo | The Journal of neuroscience | | 2008 | 674 | 0 | ||
| Aggravation of viral hepatitis by platelet-derived serotonin | Nature medicine | | 2008 | 709 | 0 |
