UNIGE document Scientific Article
previous document  unige:99531  next document
add to browser collection
Title

Clinical metagenomics for the management of hospital- and healthcare-acquired pneumonia

Authors
Schicklin, Stéphane
Guigon, Ghislaine
Published in Future Microbiology. 2016, vol. 11, no. 3, p. 427-439
Abstract The increasing burden of multidrug-resistant bacteria affects the management of several infections. In order to prescribe adequate antibiotics, clinicians facing severe infections such as hospital-acquired pneumonia (HAP) need to promptly identify the pathogens and know their antibiotic susceptibility profiles (AST), which with conventional microbiology currently requires 24 and 48 h, respectively. Clinical metagenomics, based on whole genome sequencing of clinical samples, could improve the diagnosis of HAP, however, many obstacles remain to be overcome, namely the turn-around time, the quantification of pathogens, the choice of antibiotic resistance determinants (ARDs), the inference of the AST from metagenomic data and the linkage between ARDs and their host. Here, we propose to tackle those issues in a bottom-up, clinically driven approach.
Keywords Anti-Bacterial Agents/therapeutic useBacteria/drug effects/genetics/isolation & purificationComputational BiologyCross Infection/diagnosis/drug therapy/microbiologyDisease ManagementDrug Resistance, Multiple, BacterialEnterobacteriaceae/drug effects/genetics/isolation & purificationGenome, BacterialHigh-Throughput Nucleotide SequencingHumansMetagenomicsPneumonia, Ventilator-Associated/diagnosis/drug therapy/microbiologyRisk Factors
Identifiers
PMID: 26934540
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Structures
Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
Citation
(ISO format)
RUPPE, Etienne et al. Clinical metagenomics for the management of hospital- and healthcare-acquired pneumonia. In: Future Microbiology, 2016, vol. 11, n° 3, p. 427-439. https://archive-ouverte.unige.ch/unige:99531

65 hits

0 download

Update

Deposited on : 2017-11-22

Export document
Format :
Citation style :